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CMS RVU26D · Effective 2026-10-01

88346 in Austin

Office / nonfacility

$143.37

Base rate per service

Facility setting

Not available in this setting

Base rate per service

Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.

Surgical pathology

About 88346: Initial immunofluorescence antibody stain

Reports the initial immunofluorescence antibody stain performed on a tissue specimen, such as a kidney or skin biopsy, for pathologic evaluation.

A pathology laboratory applies an antibody-based fluorescent stain to tissue so a pathologist can evaluate the pattern and location of the target in the specimen. This work is commonly part of evaluating kidney biopsies for immune deposits or skin biopsies for suspected immunobullous disease. The code represents the initial stain procedure for a specimen, not a general pathology consultation or a routine histologic stain.

Report one initial stain for the specimen; additional single-antibody immunofluorescence stains are represented by 88350. Documentation should identify the specimen and support the stain performed and the pathologist’s interpretation. CMS recognizes professional and technical components: modifier 26 identifies the interpretation, modifier TC identifies the technical work, and billing without either modifier represents the global service. CMS separately prices the 26 and TC components.

CMS billing rules for 88346

Professional and technical components
Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.

Where the value comes from

  • Work RVU0.72 · 18%
  • Practice expense (office) RVU3.35 · 82%
  • Malpractice RVU0.03 · 1%

60.9K

Medicare services in 2024 · #707 by national volume

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

88346 compared with similar codes

Office rates for Austin, from the same CMS release.

88342

Antibody stain

First single antibody per specimen

$115.23

88346 is for immunofluorescence; 88342 is for the initial immunohistochemical or immunocytochemical stain procedure.

88350

Immunofluorescence

Each additional antibody stain

$111.88

88346 represents the initial immunofluorescence stain for a specimen. 88350 represents each additional single-antibody immunofluorescence stain.

88341

Immunostain

Each additional single antibody

$98.57

88341 describes an additional immunohistochemical or immunocytochemical stain. For an additional immunofluorescence stain, the related code is 88350.

The same code, a different location

How does Austin compare?

In Beaumont, the office rate for 88346 is $126.80—$16.57 lower than the $143.37 rate in Austin. Both use the same code, release and participation basis.

88346 across payment areas

Same release and payment basis · bars start at $0

  1. Austin · This locality

    $143.37

  2. Beaumont

    $126.80

    $16.57 lower than Austin

  3. Brazoria

    $135.91

    $7.46 lower than Austin

  4. Dallas

    $136.57

    $6.80 lower than Austin

  5. Fort Worth

    $135.46

    $7.91 lower than Austin

  6. Galveston

    $136.18

    $7.19 lower than Austin

  7. Houston

    $136.73

    $6.64 lower than Austin

Other payment areas listed in Texas appear first, followed by selected cross-country examples. The chart compares amounts, not distance.

Across 109 of 109 CMS payment localities with a supported office rate, 88346 ranges from $120.68 in Arkansas to $188.58 in San Jose-Sunnyvale-Santa Clara (San Benito Cnty). This is a geographic range, not an average.

The code’s RVUs stay the same in these comparisons. Geographic adjustments to work, practice expense and malpractice change the dollar amount. A city name alone may not identify the payment area for a service address.

Compare all 108 other payment areas

  • Rest Of Texas

    Texas · 88346

    Office

    $131.14

    Facility

    Unavailable

    $12.23 lower than Austin for the office setting.

  • Los Angeles-Long Beach-Anaheim (Los Angeles/Orange Cnty)

    California · 88346

    Office

    $158.07

    Facility

    Unavailable

    $14.70 higher than Austin for the office setting.

  • Dc + Md/Va Suburbs

    District of Columbia · 88346

    Office

    $158.27

    Facility

    Unavailable

    $14.90 higher than Austin for the office setting.

  • Miami

    Florida · 88346

    Office

    $143.06

    Facility

    Unavailable

    $0.31 lower than Austin for the office setting.

  • Chicago

    Illinois · 88346

    Office

    $138.97

    Facility

    Unavailable

    $4.40 lower than Austin for the office setting.

  • Manhattan

    New York · 88346

    Office

    $157.20

    Facility

    Unavailable

    $13.83 higher than Austin for the office setting.

  • Alaska*

    Alaska · 88346

    Office

    $155.79

    Facility

    Unavailable

    $12.42 higher than Austin for the office setting.

  • Alabama

    Alabama · 88346

    Office

    $122.52

    Facility

    Unavailable

    $20.85 lower than Austin for the office setting.

  • Arkansas

    Arkansas · 88346

    Office

    $120.68

    Facility

    Unavailable

    $22.69 lower than Austin for the office setting.

  • Arizona

    Arizona · 88346

    Office

    $133.33

    Facility

    Unavailable

    $10.04 lower than Austin for the office setting.

  • Bakersfield

    California · 88346

    Office

    $147.75

    Facility

    Unavailable

    $4.38 higher than Austin for the office setting.

  • Chico

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • El Centro

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Fresno

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Hanford-Corcoran

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Madera

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Merced

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Modesto

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Napa

    California · 88346

    Office

    $173.55

    Facility

    Unavailable

    $30.18 higher than Austin for the office setting.

  • Oxnard-Thousand Oaks-Ventura

    California · 88346

    Office

    $157.60

    Facility

    Unavailable

    $14.23 higher than Austin for the office setting.

  • Redding

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Rest Of California

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Riverside-San Bernardino-Ontario

    California · 88346

    Office

    $147.97

    Facility

    Unavailable

    $4.60 higher than Austin for the office setting.

  • Sacramento-Roseville-Folsom

    California · 88346

    Office

    $155.58

    Facility

    Unavailable

    $12.21 higher than Austin for the office setting.

  • Salinas

    California · 88346

    Office

    $155.02

    Facility

    Unavailable

    $11.65 higher than Austin for the office setting.

  • San Diego-Chula Vista-Carlsbad

    California · 88346

    Office

    $159.14

    Facility

    Unavailable

    $15.77 higher than Austin for the office setting.

  • San Francisco-Oakland-Berkeley (Marin Cnty)

    California · 88346

    Office

    $184.56

    Facility

    Unavailable

    $41.19 higher than Austin for the office setting.

  • San Francisco-Oakland-Berkeley (San Francisco/San Mateo/Alameda/Contra Costa Cnty)

    California · 88346

    Office

    $184.53

    Facility

    Unavailable

    $41.16 higher than Austin for the office setting.

  • San Jose-Sunnyvale-Santa Clara (San Benito Cnty)

    California · 88346

    Office

    $188.58

    Facility

    Unavailable

    $45.21 higher than Austin for the office setting.

  • San Jose-Sunnyvale-Santa Clara (Santa Clara Cnty)

    California · 88346

    Office

    $188.44

    Facility

    Unavailable

    $45.07 higher than Austin for the office setting.

  • San Luis Obispo-Paso Robles

    California · 88346

    Office

    $152.44

    Facility

    Unavailable

    $9.07 higher than Austin for the office setting.

  • Santa Cruz-Watsonville

    California · 88346

    Office

    $161.04

    Facility

    Unavailable

    $17.67 higher than Austin for the office setting.

  • Santa Maria-Santa Barbara

    California · 88346

    Office

    $155.73

    Facility

    Unavailable

    $12.36 higher than Austin for the office setting.

  • Santa Rosa-Petaluma

    California · 88346

    Office

    $162.71

    Facility

    Unavailable

    $19.34 higher than Austin for the office setting.

  • Stockton

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Vallejo

    California · 88346

    Office

    $173.50

    Facility

    Unavailable

    $30.13 higher than Austin for the office setting.

  • Visalia

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Yuba City

    California · 88346

    Office

    $147.63

    Facility

    Unavailable

    $4.26 higher than Austin for the office setting.

  • Colorado

    Colorado · 88346

    Office

    $144.17

    Facility

    Unavailable

    $0.80 higher than Austin for the office setting.

  • Connecticut

    Connecticut · 88346

    Office

    $146.25

    Facility

    Unavailable

    $2.88 higher than Austin for the office setting.

  • Delaware

    Delaware · 88346

    Office

    $135.62

    Facility

    Unavailable

    $7.75 lower than Austin for the office setting.

  • Fort Lauderdale

    Florida · 88346

    Office

    $139.21

    Facility

    Unavailable

    $4.16 lower than Austin for the office setting.

  • Rest Of Florida

    Florida · 88346

    Office

    $132.52

    Facility

    Unavailable

    $10.85 lower than Austin for the office setting.

  • Atlanta

    Georgia · 88346

    Office

    $139.01

    Facility

    Unavailable

    $4.36 lower than Austin for the office setting.

  • Rest Of Georgia

    Georgia · 88346

    Office

    $125.05

    Facility

    Unavailable

    $18.32 lower than Austin for the office setting.

  • Hawaii, Guam

    Hawaii · 88346

    Office

    $151.85

    Facility

    Unavailable

    $8.48 higher than Austin for the office setting.

  • Iowa

    Iowa · 88346

    Office

    $126.83

    Facility

    Unavailable

    $16.54 lower than Austin for the office setting.

  • Idaho

    Idaho · 88346

    Office

    $127.46

    Facility

    Unavailable

    $15.91 lower than Austin for the office setting.

  • East St. Louis

    Illinois · 88346

    Office

    $129.01

    Facility

    Unavailable

    $14.36 lower than Austin for the office setting.

  • Rest Of Illinois

    Illinois · 88346

    Office

    $127.77

    Facility

    Unavailable

    $15.60 lower than Austin for the office setting.

  • Suburban Chicago

    Illinois · 88346

    Office

    $140.91

    Facility

    Unavailable

    $2.46 lower than Austin for the office setting.

  • Indiana

    Indiana · 88346

    Office

    $128.26

    Facility

    Unavailable

    $15.11 lower than Austin for the office setting.

  • Kansas

    Kansas · 88346

    Office

    $125.70

    Facility

    Unavailable

    $17.67 lower than Austin for the office setting.

  • Kentucky

    Kentucky · 88346

    Office

    $124.44

    Facility

    Unavailable

    $18.93 lower than Austin for the office setting.

  • New Orleans

    Louisiana · 88346

    Office

    $130.48

    Facility

    Unavailable

    $12.89 lower than Austin for the office setting.

  • Rest Of Louisiana

    Louisiana · 88346

    Office

    $124.03

    Facility

    Unavailable

    $19.34 lower than Austin for the office setting.

  • Metropolitan Boston

    Massachusetts · 88346

    Office

    $159.53

    Facility

    Unavailable

    $16.16 higher than Austin for the office setting.

  • Rest Of Massachusetts

    Massachusetts · 88346

    Office

    $143.06

    Facility

    Unavailable

    $0.31 lower than Austin for the office setting.

  • Baltimore/Surr. Cntys

    Maryland · 88346

    Office

    $145.73

    Facility

    Unavailable

    $2.36 higher than Austin for the office setting.

  • Rest Of Maryland

    Maryland · 88346

    Office

    $138.44

    Facility

    Unavailable

    $4.93 lower than Austin for the office setting.

  • Rest Of Maine

    Maine · 88346

    Office

    $127.61

    Facility

    Unavailable

    $15.76 lower than Austin for the office setting.

  • Southern Maine

    Maine · 88346

    Office

    $135.57

    Facility

    Unavailable

    $7.80 lower than Austin for the office setting.

  • Detroit

    Michigan · 88346

    Office

    $133.71

    Facility

    Unavailable

    $9.66 lower than Austin for the office setting.

  • Rest Of Michigan

    Michigan · 88346

    Office

    $127.34

    Facility

    Unavailable

    $16.03 lower than Austin for the office setting.

  • Minnesota

    Minnesota · 88346

    Office

    $139.48

    Facility

    Unavailable

    $3.89 lower than Austin for the office setting.

  • Metropolitan Kansas City

    Missouri · 88346

    Office

    $130.10

    Facility

    Unavailable

    $13.27 lower than Austin for the office setting.

  • Metropolitan St. Louis

    Missouri · 88346

    Office

    $131.57

    Facility

    Unavailable

    $11.80 lower than Austin for the office setting.

  • Rest Of Missouri

    Missouri · 88346

    Office

    $121.48

    Facility

    Unavailable

    $21.89 lower than Austin for the office setting.

  • Mississippi

    Mississippi · 88346

    Office

    $121.13

    Facility

    Unavailable

    $22.24 lower than Austin for the office setting.

  • Montana**

    Montana · 88346

    Office

    $136.94

    Facility

    Unavailable

    $6.43 lower than Austin for the office setting.

  • North Carolina

    North Carolina · 88346

    Office

    $129.09

    Facility

    Unavailable

    $14.28 lower than Austin for the office setting.

  • North Dakota**

    North Dakota · 88346

    Office

    $136.35

    Facility

    Unavailable

    $7.02 lower than Austin for the office setting.

  • Nebraska

    Nebraska · 88346

    Office

    $127.70

    Facility

    Unavailable

    $15.67 lower than Austin for the office setting.

  • New Hampshire

    New Hampshire · 88346

    Office

    $141.41

    Facility

    Unavailable

    $1.96 lower than Austin for the office setting.

  • Northern Nj

    New Jersey · 88346

    Office

    $156.43

    Facility

    Unavailable

    $13.06 higher than Austin for the office setting.

  • Rest Of New Jersey

    New Jersey · 88346

    Office

    $148.30

    Facility

    Unavailable

    $4.93 higher than Austin for the office setting.

  • New Mexico

    New Mexico · 88346

    Office

    $127.86

    Facility

    Unavailable

    $15.51 lower than Austin for the office setting.

  • Nevada**

    Nevada · 88346

    Office

    $136.89

    Facility

    Unavailable

    $6.48 lower than Austin for the office setting.

  • Nyc Suburbs/Long Island

    New York · 88346

    Office

    $160.49

    Facility

    Unavailable

    $17.12 higher than Austin for the office setting.

  • Poughkpsie/N Nyc Suburbs

    New York · 88346

    Office

    $148.87

    Facility

    Unavailable

    $5.50 higher than Austin for the office setting.

  • Queens

    New York · 88346

    Office

    $159.29

    Facility

    Unavailable

    $15.92 higher than Austin for the office setting.

  • Rest Of New York

    New York · 88346

    Office

    $131.05

    Facility

    Unavailable

    $12.32 lower than Austin for the office setting.

  • Ohio

    Ohio · 88346

    Office

    $127.22

    Facility

    Unavailable

    $16.15 lower than Austin for the office setting.

  • Oklahoma

    Oklahoma · 88346

    Office

    $124.75

    Facility

    Unavailable

    $18.62 lower than Austin for the office setting.

  • Portland

    Oregon · 88346

    Office

    $149.49

    Facility

    Unavailable

    $6.12 higher than Austin for the office setting.

  • Rest Of Oregon

    Oregon · 88346

    Office

    $136.20

    Facility

    Unavailable

    $7.17 lower than Austin for the office setting.

  • Metropolitan Philadelphia

    Pennsylvania · 88346

    Office

    $142.16

    Facility

    Unavailable

    $1.21 lower than Austin for the office setting.

  • Rest Of Pennsylvania

    Pennsylvania · 88346

    Office

    $127.71

    Facility

    Unavailable

    $15.66 lower than Austin for the office setting.

  • Puerto Rico

    Puerto Rico · 88346

    Office

    $138.16

    Facility

    Unavailable

    $5.21 lower than Austin for the office setting.

  • Rhode Island

    Rhode Island · 88346

    Office

    $140.98

    Facility

    Unavailable

    $2.39 lower than Austin for the office setting.

  • South Carolina

    South Carolina · 88346

    Office

    $128.29

    Facility

    Unavailable

    $15.08 lower than Austin for the office setting.

  • South Dakota**

    South Dakota · 88346

    Office

    $136.28

    Facility

    Unavailable

    $7.09 lower than Austin for the office setting.

  • Tennessee

    Tennessee · 88346

    Office

    $126.30

    Facility

    Unavailable

    $17.07 lower than Austin for the office setting.

  • Utah

    Utah · 88346

    Office

    $130.13

    Facility

    Unavailable

    $13.24 lower than Austin for the office setting.

  • Virginia

    Virginia · 88346

    Office

    $134.75

    Facility

    Unavailable

    $8.62 lower than Austin for the office setting.

  • Virgin Islands

    United States Virgin Islands · 88346

    Office

    $138.16

    Facility

    Unavailable

    $5.21 lower than Austin for the office setting.

  • Vermont

    Vermont · 88346

    Office

    $135.33

    Facility

    Unavailable

    $8.04 lower than Austin for the office setting.

  • Rest Of Washington

    Washington · 88346

    Office

    $142.95

    Facility

    Unavailable

    $0.42 lower than Austin for the office setting.

  • Seattle (King Cnty)

    Washington · 88346

    Office

    $163.36

    Facility

    Unavailable

    $19.99 higher than Austin for the office setting.

  • Wisconsin

    Wisconsin · 88346

    Office

    $131.55

    Facility

    Unavailable

    $11.82 lower than Austin for the office setting.

  • West Virginia

    West Virginia · 88346

    Office

    $122.72

    Facility

    Unavailable

    $20.65 lower than Austin for the office setting.

  • Wyoming**

    Wyoming · 88346

    Office

    $136.68

    Facility

    Unavailable

    $6.69 lower than Austin for the office setting.

See how rates vary across the country

88346 · Office / nonfacility · Non-QP. Choose a state to explore its payment localities. A range means the amount varies within that state.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$120.68

$168.11

Color shows the midpoint of each state’s locality range.

View all state and territory rates as a table
State / territoryRate rangeLocalities
AK$155.791
AL$122.521
AR$120.681
AZ$133.331
CA$147.63–$188.5829
CO$144.171
CT$146.251
DC$158.271
DE$135.621
FL$132.52–$143.063
GA$125.05–$139.012
GU$151.851
HI$151.851
IA$126.831
ID$127.461
IL$127.77–$140.914
IN$128.261
KS$125.701
KY$124.441
LA$124.03–$130.482
MA$143.06–$159.532
MD$138.44–$158.273
ME$127.61–$135.572
MI$127.34–$133.712
MN$139.481
MO$121.48–$131.573
MS$121.131
MT$136.941
NC$129.091
ND$136.351
NE$127.701
NH$141.411
NJ$148.30–$156.432
NM$127.861
NV$136.891
NY$131.05–$160.495
OH$127.221
OK$124.751
OR$136.20–$149.492
PA$127.71–$142.162
PR$138.161
RI$140.981
SC$128.291
SD$136.281
TN$126.301
TX$126.80–$143.378
UT$130.131
VA$134.75–$158.272
VI$138.161
VT$135.331
WA$142.95–$163.362
WI$131.551
WV$122.721
WY$136.681

Explore 88346 on the national rate map →

Where does this rate apply?

Austin is a Medicare payment area. Our Census mapping connects it to 31 cities and communities in Texas, including the examples shown here.

Some communities span more than one payment area. Follow a city link to compare all of its mapped areas, or check the service-location ZIP above for an address-level starting point.

Browse all communities in Texas →

Use this rate

What is a percentage of Medicare worth?

Turn a percentage into dollars for 88346 in Austin. This uses the base rate on this page, so the locality and release stay consistent.

Reference amount per service

$157.71

$143.37 × 110% = $157.71

A contract may specify another Medicare year or additional adjustments. This is percentage arithmetic on the displayed base rate, not a claim adjudication.

Working with a whole code list?

Compare an offer across your annual code mix, including an older Medicare schedule or flat per-code rates.

Compare your contract offer →

How this local rate is calculated

Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88346 in Austin.

PPRRVU2026_Oct_nonQPP.csv

11,257

Code
88346
Physician work
0.72
Practice expense
3.35
Malpractice
0.03

GPCI2026.csv

96

Locality
Austin
Physician work
1.002
Practice expense
1.058
Malpractice
0.886
Office / nonfacility calculation for 88346 in Austin
ComponentRVULocality factorAdjusted
Physician work0.72× 1.0020.7214
Practice expense3.35× 1.0583.5443
Malpractice0.03× 0.8860.0266
Total RVUs4.2923
Conversion factor× 33.4009

Office / nonfacility rate, Austin$143.37

Values as parsed from CMS release RVU26D, effective 2026-10-01. The amount is rounded to the nearest cent only at the end.

Open 88346 in the RVU calculator →

Explore RVUs, geographic factors and the full formula

Office / nonfacility

Office / nonfacility calculation inputs
ComponentRVULocal GPCI
Work0.721.002
Practice expense3.351.058
Malpractice0.030.886

(0.72 × 1.002 + 3.35 × 1.058 + 0.03 × 0.886) × $33.4009 = $143.37

The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.

How this rate has changed

88346 · Office / nonfacility

$143.37

Effective 2026-10-01

The base rate is $1.90 lower than on 2025-10-01, moving from $145.27 to $143.37 (1.3%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    $145.27changed to$143.37

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 0.74 changed to 0.72
    • Practice expense RVU 3.56 changed to 3.35
    • Work GPCI 1.000 changed to 1.002
    • Practice expense GPCI 1.046 changed to 1.058
    • Malpractice GPCI 0.914 changed to 0.886

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    Earliest loaded release: $145.27

    Held through RVU25B, RVU25C, RVU25D.

Explore release dates and calculate this code in an earlier period →

Each row uses the accepted CMS release effective on that date and the same contractor and locality identifiers. Missing rates stay visible. Historical boundaries may differ; verify the service address for an older claim.

Inspect every release and its CMS source
Effective fromOffice / nonfacilityFacilityCMS release
2026-10-01$143.37Not available in this settingRVU26D
2026-07-01$143.37Not available in this settingRVU26C
2026-04-01$143.37Not available in this settingRVU26B
2026-01-01$143.37Not available in this settingRVU26A
2025-10-01$145.27Not available in this settingRVU25D
2025-07-01$145.27Not available in this settingRVU25C
2025-04-01$145.27Not available in this settingRVU25B
2025-01-01$145.27Not available in this settingRVU25A

88346 billing questions

When should 88346 be selected instead of 88342?

Use 88346 for an immunofluorescence stain. Code 88342 describes an immunohistochemical or immunocytochemical stain, a different laboratory method.

How are additional immunofluorescence stains reported?

Report 88346 for the initial single-antibody stain on the specimen. Use 88350 for each additional single-antibody immunofluorescence stain when supported by the work performed.

Can the professional and technical work be billed separately?

Yes. Modifier 26 identifies the professional interpretation, and modifier TC identifies the technical work. Without either modifier, the claim represents the global service.

What documentation supports reporting 88346?

Document the tissue specimen, the immunofluorescence stain performed, and the pathologist’s interpretation. The record should support that this is the initial stain for that specimen.

Is 88346 reported per slide or per specimen?

The code is per specimen. It represents the initial stain procedure for that specimen, rather than a separate unit for every slide prepared.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.

Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.

RVUs for 88346PPRRVU2026_Oct_nonQPP.csv, line 11,257 (RVU26D)
Geographic factors for AustinGPCI2026.csv, line 96 (RVU26D)
Open CMS sourceHow this rate is calculatedBuild a fee sheet