64642 covers the primary extremity treated with one to four muscles. 64643 is for each additional extremity in that same muscle-count range.
On this page
CMS RVU26D · Effective 2026-10-01
64643 in Fresno
Office / nonfacility
$102.01
Base rate per service
Facility setting
$58.09
Base rate per service
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
Chemodenervation
About 64643: Additional-extremity chemodenervation, 1-4 muscles
Reports chemodenervation of an additional extremity when treatment targets one to four muscles there, alongside the primary extremity procedure.
This add-on code represents chemodenervation of an additional limb, treating one to four muscles in that extremity. It is commonly used when a clinician injects botulinum toxin to manage focal spasticity, such as after stroke, traumatic brain injury, or in cerebral palsy. Physicians and other qualified practitioners typically perform the injections in an office or facility setting, selecting target muscles based on the patient’s functional goals and examination findings.
Report 64643 with the primary extremity chemodenervation service, generally 64642, when another extremity is treated at the same session. The muscle count is assessed separately for each extremity; this code represents an additional extremity with one to four treated muscles, not each individual muscle or injection site. Documentation should identify the treated extremity, muscles, indication, and administered treatment. CMS classifies this as an add-on code: it is billed only with a primary procedure, and its payment falls within that procedure’s global period.
CMS billing rules for 64643
- Global period
- Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
Where the value comes from
- Work RVU1.19 · 40%
- Practice expense (office) RVU1.57 · 53%
- Malpractice RVU0.23 · 8%
38.6K
Medicare services in 2024 · #885 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
64643 compared with similar codes
Office rates for Fresno, from the same CMS release.
64644 applies to the primary extremity when five or more muscles are treated; 64643 is for an additional extremity with one to four muscles.
Both codes describe an additional extremity, but 64645 is used when five or more muscles are treated there; 64643 is for one to four.
The same code, a different location
How does Fresno compare?
In Bakersfield, the office rate for 64643 is $102.65—$0.64 higher than the $102.01 rate in Fresno. Both use the same code, release and participation basis.
64643 across payment areas
Same release and payment basis · bars start at $0
Fresno · This locality
$102.01
$102.65
$0.64 higher than Fresno
$102.01
The same base rate than Fresno
$102.05
$0.04 higher than Fresno
$102.01
The same base rate than Fresno
$6.50 higher than Fresno
$102.01
The same base rate than Fresno
Other payment areas listed in California appear first, followed by selected cross-country examples. The chart compares amounts, not distance.
Across 109 of 109 CMS payment localities with a supported office rate, 64643 ranges from $88.75 in Arkansas to $123.85 in San Jose-Sunnyvale-Santa Clara (San Benito Cnty). This is a geographic range, not an average.
The code’s RVUs stay the same in these comparisons. Geographic adjustments to work, practice expense and malpractice change the dollar amount. A city name alone may not identify the payment area for a service address.
Compare all 108 other payment areas
Merced
California · 64643
Office
$102.01
Facility
$58.09
The same base rate than Fresno for the office setting.
Modesto
California · 64643
Office
$102.01
Facility
$58.09
The same base rate than Fresno for the office setting.
Napa
California · 64643
Office
$115.27
Facility
$62.44
$13.26 higher than Fresno for the office setting.
Oxnard-Thousand Oaks-Ventura
California · 64643
Office
$107.63
Facility
$60.25
$5.62 higher than Fresno for the office setting.
Redding
California · 64643
Office
$102.01
Facility
$58.09
The same base rate than Fresno for the office setting.
Rest Of California
California · 64643
Office
$102.01
Facility
$58.09
The same base rate than Fresno for the office setting.
Riverside-San Bernardino-Ontario
California · 64643
Office
$104.49
Facility
$60.56
$2.48 higher than Fresno for the office setting.
Sacramento-Roseville-Folsom
California · 64643
Office
$106.28
Facility
$59.67
$4.27 higher than Fresno for the office setting.
Salinas
California · 64643
Office
$105.87
Facility
$59.42
$3.86 higher than Fresno for the office setting.
San Diego-Chula Vista-Carlsbad
California · 64643
Office
$107.82
Facility
$59.88
$5.81 higher than Fresno for the office setting.
San Francisco-Oakland-Berkeley (Marin Cnty)
California · 64643
Office
$120.99
Facility
$64.47
$18.98 higher than Fresno for the office setting.
San Francisco-Oakland-Berkeley (San Francisco/San Mateo/Alameda/Contra Costa Cnty)
California · 64643
Office
$120.73
Facility
$64.21
$18.72 higher than Fresno for the office setting.
San Jose-Sunnyvale-Santa Clara (San Benito Cnty)
California · 64643
Office
$123.85
Facility
$66.06
$21.84 higher than Fresno for the office setting.
San Jose-Sunnyvale-Santa Clara (Santa Clara Cnty)
California · 64643
Office
$122.79
Facility
$64.99
$20.78 higher than Fresno for the office setting.
San Luis Obispo-Paso Robles
California · 64643
Office
$104.27
Facility
$58.62
$2.26 higher than Fresno for the office setting.
Santa Cruz-Watsonville
California · 64643
Office
$108.41
Facility
$59.71
$6.40 higher than Fresno for the office setting.
Santa Maria-Santa Barbara
California · 64643
Office
$106.12
Facility
$59.39
$4.11 higher than Fresno for the office setting.
Santa Rosa-Petaluma
California · 64643
Office
$109.45
Facility
$60.23
$7.44 higher than Fresno for the office setting.
Stockton
California · 64643
Office
$102.01
Facility
$58.09
The same base rate than Fresno for the office setting.
Vallejo
California · 64643
Office
$114.89
Facility
$62.07
$12.88 higher than Fresno for the office setting.
Visalia
California · 64643
Office
$102.01
Facility
$58.09
The same base rate than Fresno for the office setting.
Yuba City
California · 64643
Office
$102.01
Facility
$58.09
The same base rate than Fresno for the office setting.
Dc + Md/Va Suburbs
District of Columbia · 64643
Office
$112.22
Facility
$65.00
$10.21 higher than Fresno for the office setting.
Miami
Florida · 64643
Office
$113.76
Facility
$72.04
$11.75 higher than Fresno for the office setting.
Chicago
Illinois · 64643
Office
$110.36
Facility
$70.08
$8.35 higher than Fresno for the office setting.
Manhattan
New York · 64643
Office
$115.41
Facility
$68.84
$13.40 higher than Fresno for the office setting.
Alaska*
Alaska · 64643
Office
$119.70
Facility
$77.02
$17.69 higher than Fresno for the office setting.
Alabama
Alabama · 64643
Office
$89.98
Facility
$54.91
$12.03 lower than Fresno for the office setting.
Arkansas
Arkansas · 64643
Office
$88.75
Facility
$54.32
$13.26 lower than Fresno for the office setting.
Arizona
Arizona · 64643
Office
$97.14
Facility
$58.30
$4.87 lower than Fresno for the office setting.
Colorado
Colorado · 64643
Office
$102.02
Facility
$59.37
$0.01 higher than Fresno for the office setting.
Connecticut
Connecticut · 64643
Office
$106.31
Facility
$63.15
$4.30 higher than Fresno for the office setting.
Delaware
Delaware · 64643
Office
$98.66
Facility
$59.06
$3.35 lower than Fresno for the office setting.
Fort Lauderdale
Florida · 64643
Office
$106.76
Facility
$66.16
$4.75 higher than Fresno for the office setting.
Rest Of Florida
Florida · 64643
Office
$101.43
Facility
$63.11
$0.58 lower than Fresno for the office setting.
Atlanta
Georgia · 64643
Office
$102.37
Facility
$61.65
$0.36 higher than Fresno for the office setting.
Rest Of Georgia
Georgia · 64643
Office
$95.68
Facility
$59.93
$6.33 lower than Fresno for the office setting.
Hawaii, Guam
Hawaii · 64643
Office
$103.82
Facility
$58.25
$1.81 higher than Fresno for the office setting.
Iowa
Iowa · 64643
Office
$90.78
Facility
$54.10
$11.23 lower than Fresno for the office setting.
Idaho
Idaho · 64643
Office
$91.63
Facility
$54.75
$10.38 lower than Fresno for the office setting.
East St. Louis
Illinois · 64643
Office
$103.46
Facility
$66.59
$1.45 higher than Fresno for the office setting.
Rest Of Illinois
Illinois · 64643
Office
$99.63
Facility
$63.04
$2.38 lower than Fresno for the office setting.
Suburban Chicago
Illinois · 64643
Office
$107.49
Facility
$66.33
$5.48 higher than Fresno for the office setting.
Indiana
Indiana · 64643
Office
$92.09
Facility
$54.94
$9.92 lower than Fresno for the office setting.
Kansas
Kansas · 64643
Office
$91.02
Facility
$54.79
$10.99 lower than Fresno for the office setting.
Kentucky
Kentucky · 64643
Office
$93.39
Facility
$57.76
$8.62 lower than Fresno for the office setting.
New Orleans
Louisiana · 64643
Office
$97.82
Facility
$60.10
$4.19 lower than Fresno for the office setting.
Rest Of Louisiana
Louisiana · 64643
Office
$93.52
Facility
$58.04
$8.49 lower than Fresno for the office setting.
Metropolitan Boston
Massachusetts · 64643
Office
$110.83
Facility
$62.97
$8.82 higher than Fresno for the office setting.
Rest Of Massachusetts
Massachusetts · 64643
Office
$101.72
Facility
$59.52
$0.29 lower than Fresno for the office setting.
Baltimore/Surr. Cntys
Maryland · 64643
Office
$106.15
Facility
$63.15
$4.14 higher than Fresno for the office setting.
Rest Of Maryland
Maryland · 64643
Office
$100.27
Facility
$59.70
$1.74 lower than Fresno for the office setting.
Rest Of Maine
Maine · 64643
Office
$92.77
Facility
$55.90
$9.24 lower than Fresno for the office setting.
Southern Maine
Maine · 64643
Office
$96.56
Facility
$56.84
$5.45 lower than Fresno for the office setting.
Detroit
Michigan · 64643
Office
$103.30
Facility
$64.63
$1.29 higher than Fresno for the office setting.
Rest Of Michigan
Michigan · 64643
Office
$96.30
Facility
$59.70
$5.71 lower than Fresno for the office setting.
Minnesota
Minnesota · 64643
Office
$95.98
Facility
$54.74
$6.03 lower than Fresno for the office setting.
Metropolitan Kansas City
Missouri · 64643
Office
$96.49
Facility
$58.86
$5.52 lower than Fresno for the office setting.
Metropolitan St. Louis
Missouri · 64643
Office
$97.37
Facility
$59.21
$4.64 lower than Fresno for the office setting.
Rest Of Missouri
Missouri · 64643
Office
$92.43
Facility
$57.88
$9.58 lower than Fresno for the office setting.
Mississippi
Mississippi · 64643
Office
$90.57
Facility
$56.06
$11.44 lower than Fresno for the office setting.
Montana**
Montana · 64643
Office
$99.85
Facility
$59.77
$2.16 lower than Fresno for the office setting.
North Carolina
North Carolina · 64643
Office
$93.58
Facility
$56.19
$8.43 lower than Fresno for the office setting.
North Dakota**
North Dakota · 64643
Office
$95.31
Facility
$55.22
$6.70 lower than Fresno for the office setting.
Nebraska
Nebraska · 64643
Office
$91.05
Facility
$54.06
$10.96 lower than Fresno for the office setting.
New Hampshire
New Hampshire · 64643
Office
$101.06
Facility
$59.33
$0.95 lower than Fresno for the office setting.
Northern Nj
New Jersey · 64643
Office
$111.29
Facility
$64.79
$9.28 higher than Fresno for the office setting.
Rest Of New Jersey
New Jersey · 64643
Office
$107.03
Facility
$63.26
$5.02 higher than Fresno for the office setting.
New Mexico
New Mexico · 64643
Office
$97.06
Facility
$60.31
$4.95 lower than Fresno for the office setting.
Nevada**
Nevada · 64643
Office
$98.64
Facility
$58.52
$3.37 lower than Fresno for the office setting.
Nyc Suburbs/Long Island
New York · 64643
Office
$118.91
Facility
$71.25
$16.90 higher than Fresno for the office setting.
Poughkpsie/N Nyc Suburbs
New York · 64643
Office
$108.25
Facility
$64.36
$6.24 higher than Fresno for the office setting.
Queens
New York · 64643
Office
$115.35
Facility
$67.98
$13.34 higher than Fresno for the office setting.
Rest Of New York
New York · 64643
Office
$94.97
Facility
$56.89
$7.04 lower than Fresno for the office setting.
Ohio
Ohio · 64643
Office
$95.37
Facility
$58.77
$6.64 lower than Fresno for the office setting.
Oklahoma
Oklahoma · 64643
Office
$92.54
Facility
$56.75
$9.47 lower than Fresno for the office setting.
Portland
Oregon · 64643
Office
$104.36
Facility
$59.83
$2.35 higher than Fresno for the office setting.
Rest Of Oregon
Oregon · 64643
Office
$97.38
Facility
$57.46
$4.63 lower than Fresno for the office setting.
Metropolitan Philadelphia
Pennsylvania · 64643
Office
$104.22
Facility
$62.49
$2.21 higher than Fresno for the office setting.
Rest Of Pennsylvania
Pennsylvania · 64643
Office
$95.15
Facility
$58.35
$6.86 lower than Fresno for the office setting.
Puerto Rico
Puerto Rico · 64643
Office
$100.33
Facility
$59.81
$1.68 lower than Fresno for the office setting.
Rhode Island
Rhode Island · 64643
Office
$101.52
Facility
$60.12
$0.49 lower than Fresno for the office setting.
South Carolina
South Carolina · 64643
Office
$94.73
Facility
$57.70
$7.28 lower than Fresno for the office setting.
South Dakota**
South Dakota · 64643
Office
$94.77
Facility
$54.69
$7.24 lower than Fresno for the office setting.
Tennessee
Tennessee · 64643
Office
$91.54
Facility
$55.11
$10.47 lower than Fresno for the office setting.
Austin
Texas · 64643
Office
$102.11
Facility
$59.71
$0.10 higher than Fresno for the office setting.
Beaumont
Texas · 64643
Office
$94.60
Facility
$58.13
$7.41 lower than Fresno for the office setting.
Brazoria
Texas · 64643
Office
$98.02
Facility
$58.30
$3.99 lower than Fresno for the office setting.
Dallas
Texas · 64643
Office
$98.93
Facility
$59.01
$3.08 lower than Fresno for the office setting.
Fort Worth
Texas · 64643
Office
$98.50
Facility
$58.98
$3.51 lower than Fresno for the office setting.
Galveston
Texas · 64643
Office
$98.50
Facility
$58.70
$3.51 lower than Fresno for the office setting.
Houston
Texas · 64643
Office
$102.71
Facility
$62.91
$0.70 higher than Fresno for the office setting.
Rest Of Texas
Texas · 64643
Office
$96.45
Facility
$58.41
$5.56 lower than Fresno for the office setting.
Utah
Utah · 64643
Office
$95.94
Facility
$58.26
$6.07 lower than Fresno for the office setting.
Virginia
Virginia · 64643
Office
$96.72
Facility
$57.32
$5.29 lower than Fresno for the office setting.
Virgin Islands
United States Virgin Islands · 64643
Office
$100.33
Facility
$59.81
$1.68 lower than Fresno for the office setting.
Vermont
Vermont · 64643
Office
$95.55
Facility
$55.87
$6.46 lower than Fresno for the office setting.
Rest Of Washington
Washington · 64643
Office
$101.33
Facility
$59.12
$0.68 lower than Fresno for the office setting.
Seattle (King Cnty)
Washington · 64643
Office
$112.35
Facility
$63.17
$10.34 higher than Fresno for the office setting.
Wisconsin
Wisconsin · 64643
Office
$92.35
Facility
$53.95
$9.66 lower than Fresno for the office setting.
West Virginia
West Virginia · 64643
Office
$96.31
Facility
$61.48
$5.70 lower than Fresno for the office setting.
Wyoming**
Wyoming · 64643
Office
$97.87
Facility
$57.79
$4.14 lower than Fresno for the office setting.
See how rates vary across the country
64643 · Office / nonfacility · Non-QP. Choose a state to explore its payment localities. A range means the amount varies within that state.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$88.75
$119.70
Color shows the midpoint of each state’s locality range.
View all state and territory rates as a table
| State / territory | Rate range | Localities |
|---|---|---|
| AK | $119.70 | 1 |
| AL | $89.98 | 1 |
| AR | $88.75 | 1 |
| AZ | $97.14 | 1 |
| CA | $102.01–$123.85 | 29 |
| CO | $102.02 | 1 |
| CT | $106.31 | 1 |
| DC | $112.22 | 1 |
| DE | $98.66 | 1 |
| FL | $101.43–$113.76 | 3 |
| GA | $95.68–$102.37 | 2 |
| GU | $103.82 | 1 |
| HI | $103.82 | 1 |
| IA | $90.78 | 1 |
| ID | $91.63 | 1 |
| IL | $99.63–$110.36 | 4 |
| IN | $92.09 | 1 |
| KS | $91.02 | 1 |
| KY | $93.39 | 1 |
| LA | $93.52–$97.82 | 2 |
| MA | $101.72–$110.83 | 2 |
| MD | $100.27–$112.22 | 3 |
| ME | $92.77–$96.56 | 2 |
| MI | $96.30–$103.30 | 2 |
| MN | $95.98 | 1 |
| MO | $92.43–$97.37 | 3 |
| MS | $90.57 | 1 |
| MT | $99.85 | 1 |
| NC | $93.58 | 1 |
| ND | $95.31 | 1 |
| NE | $91.05 | 1 |
| NH | $101.06 | 1 |
| NJ | $107.03–$111.29 | 2 |
| NM | $97.06 | 1 |
| NV | $98.64 | 1 |
| NY | $94.97–$118.91 | 5 |
| OH | $95.37 | 1 |
| OK | $92.54 | 1 |
| OR | $97.38–$104.36 | 2 |
| PA | $95.15–$104.22 | 2 |
| PR | $100.33 | 1 |
| RI | $101.52 | 1 |
| SC | $94.73 | 1 |
| SD | $94.77 | 1 |
| TN | $91.54 | 1 |
| TX | $94.60–$102.71 | 8 |
| UT | $95.94 | 1 |
| VA | $96.72–$112.22 | 2 |
| VI | $100.33 | 1 |
| VT | $95.55 | 1 |
| WA | $101.33–$112.35 | 2 |
| WI | $92.35 | 1 |
| WV | $96.31 | 1 |
| WY | $97.87 | 1 |
Where does this rate apply?
Fresno is a Medicare payment area. Our Census mapping connects it to 45 cities and communities in California, including the examples shown here.
Some communities span more than one payment area. Follow a city link to compare all of its mapped areas, or check the service-location ZIP above for an address-level starting point.
Why are the office and facility amounts different?
For 64643 in Fresno, the physician’s office rate is $102.01 and the facility-setting rate is $58.09: a difference of $43.92.
The calculation uses a different practice-expense RVU for each setting. Both amounts here are physician fee-schedule amounts. The facility figure does not include a hospital’s separate charges, so this comparison does not tell you the total cost of receiving care in each setting.
Use this rate
What is a percentage of Medicare worth?
Turn a percentage into dollars for 64643 in Fresno. This uses the base rate on this page, so the locality and release stay consistent.
Reference amount per service
$112.21
$102.01 × 110% = $112.21
A contract may specify another Medicare year or additional adjustments. This is percentage arithmetic on the displayed base rate, not a claim adjudication.
Working with a whole code list?
Compare an offer across your annual code mix, including an older Medicare schedule or flat per-code rates.
How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 64643 in Fresno.
PPRRVU2026_Oct_nonQPP.csv
7,186
- Code
- 64643
- Physician work
- 1.19
- Practice expense
- 1.57
- Malpractice
- 0.23
GPCI2026.csv
11
- Locality
- Fresno
- Physician work
- 1.017
- Practice expense
- 1.096
- Malpractice
- 0.536
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 1.19 | × 1.017 | 1.2102 |
| Practice expense | 1.57 | × 1.096 | 1.7207 |
| Malpractice | 0.23 | × 0.536 | 0.1233 |
| Total RVUs | 3.0542 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Fresno$102.01
Open 64643 in the RVU calculator →
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 1.19 | 1.017 |
| Practice expense | 1.57 | 1.096 |
| Malpractice | 0.23 | 0.536 |
(1.19 × 1.017 + 1.57 × 1.096 + 0.23 × 0.536) × $33.4009 = $102.01
Facility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 1.19 | 1.017 |
| Practice expense | 0.37 | 1.096 |
| Malpractice | 0.23 | 0.536 |
(1.19 × 1.017 + 0.37 × 1.096 + 0.23 × 0.536) × $33.4009 = $58.09
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
How this rate has changed
64643 · Office / nonfacility
$102.01
Effective 2026-10-01
The base rate is $9.75 higher than on 2025-10-01, moving from $92.26 to $102.01 (10.6%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$92.26changed to$102.01
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 1.22 changed to 1.19
- Practice expense RVU 1.36 changed to 1.57
- Work GPCI 1.014 changed to 1.017
- Practice expense GPCI 1.093 changed to 1.096
- Malpractice GPCI 0.560 changed to 0.536
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
Earliest loaded release: $92.26
Held through RVU25B, RVU25C, RVU25D.
Explore release dates and calculate this code in an earlier period →
Each row uses the accepted CMS release effective on that date and the same contractor and locality identifiers. Missing rates stay visible. Historical boundaries may differ; verify the service address for an older claim.
Inspect every release and its CMS source
64643 billing questions
When is 64643 used instead of 64642?
64642 reports the primary extremity treated with one to four muscles. Use 64643 for each additional extremity treated with one to four muscles during the service.
Can 64643 be billed by itself?
No. It is an add-on code and must be reported with a primary procedure, generally 64642 for the first extremity.
Is the code counted per muscle or per extremity?
It is counted per additional extremity. The extremity must have one to four muscles treated; the code is not reported once for each muscle or injection site.
When should 64645 be used instead?
Use 64645 for an additional extremity when five or more muscles are treated there. The one-to-four muscle threshold is evaluated separately for each extremity.
What documentation supports 64643?
Document the additional extremity, the muscles treated in that limb, the indication for chemodenervation, and the treatment performed.
How does the global-period rule affect 64643?
CMS treats 64643 as an add-on service paid within the primary procedure’s global period. It must accompany a primary procedure.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
