$206.61
Choose 88380 when a laser captures selected tissue from a section; 88381 describes manual microdissection.
On this page
CMS RVU26D · Effective 2026-10-01
88380 Tissue microdissection Medicare reimbursement rates in Alaska
Reports laser capture microdissection of a tissue section to isolate selected cells, typically preparing a specimen for downstream molecular analysis. Compare 88380 office and facility rates across CMS payment localities in Alaska.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88380 in Alaska?
Alaska has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$140.65
1 of 1 localities have a supported rate.
Payment area: Alaska*
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88380: Laser capture tissue microdissection
Reports laser capture microdissection of a tissue section to isolate selected cells, typically preparing a specimen for downstream molecular analysis.
A laboratory uses a laser under microscopic visualization to separate selected cells or tissue from a section, such as a tumor focus mixed with surrounding benign tissue. The enriched material can then be used for molecular testing. This service is typically performed by pathology laboratory personnel as part of a surgical pathology or molecular diagnostic workflow; the interpreting pathologist may provide the professional component.
Report the service for each tissue section subjected to laser capture microdissection. Documentation should identify the specimen and section, the tissue or cell population selected, and the laser-capture work performed. This code represents specimen preparation, not the downstream molecular assay or its interpretation. CMS recognizes professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the technical service, and an unmodified claim represents the global service.
CMS billing rules for 88380
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU1.11 · 32%
- Practice expense (office) RVU2.37 · 67%
- Malpractice RVU0.04 · 1%
334
Medicare services in 2024 · #3911 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88380 compared with similar codes
Office rates for Alaska, from the same CMS release.
$43.23
88387 covers macroscopic examination, dissection, and preparation of tissue for molecular studies. 88380 is the laser-based isolation of selected cells or tissue.
$29.08
88363 concerns retrieval of archived tissue for molecular analysis; 88380 reports laser capture microdissection of tissue from a section.
Compare 88380 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Alaska* →
Office / nonfacility
$140.65
Facility
Unavailable
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How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88380 in Alaska*.
PPRRVU2026_Oct_nonQPP.csv
11,317
- Code
- 88380
- Physician work
- 1.11
- Practice expense
- 2.37
- Malpractice
- 0.04
GPCI2026.csv
5
- Locality
- Alaska*
- Physician work
- 1.500
- Practice expense
- 1.065
- Malpractice
- 0.551
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 1.11 | × 1.500 | 1.6650 |
| Practice expense | 2.37 | × 1.065 | 2.5240 |
| Malpractice | 0.04 | × 0.551 | 0.0220 |
| Total RVUs | 4.2111 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Alaska*$140.65
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 1.11 | 1.5 |
| Practice expense | 2.37 | 1.065 |
| Malpractice | 0.04 | 0.551 |
(1.11 × 1.5 + 2.37 × 1.065 + 0.04 × 0.551) × $33.4009 = $140.65
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88380 billing questions
How is 88380 different from manual microdissection?
88380 is for laser capture of selected tissue from a section. Use 88381 when the microdissection is performed manually.
Does 88380 include the molecular test?
No. It represents laser-based isolation of tissue for analysis, not the downstream molecular assay or its result.
Which modifiers identify the components?
Modifier 26 reports the professional component, modifier TC reports the technical component, and no modifier represents the global service.
What supports reporting the service?
Record the specimen and tissue section, the selected cell population or target tissue, and that laser capture microdissection was performed.
How many units are reported?
The code is reported per tissue section subjected to laser capture microdissection. The documentation should support the number of sections processed.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,31488377,,M/phmtrc alys ishquant/semiq,A,,1.37,10.09,,10.09,NA,0.04,11.50,11.50,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31588377,26,M/phmtrc alys ishquant/semiq,A,,1.37,0.44,,0.44,,0.01,1.82,1.82,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31688377,TC,M/phmtrc alys ishquant/semiq,A,,0.00,9.65,,9.65,NA,0.03,9.68,9.68,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31788380,,Microdissection laser,A,,1.11,2.37,,2.37,NA,0.04,3.52,3.52,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31888380,26,Microdissection laser,A,,1.11,0.33,,0.33,,0.01,1.45,1.45,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31988380,TC,Microdissection laser,A,,0.00,2.04,,2.04,NA,0.03,2.07,2.07,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,32088381,,Microdissection manual,A,,0.52,5.05,,5.05,NA,0.05,5.62,5.62,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
2,,,,,,
3Medicare Administrative Contractor (MAC),State,Locality Number,Locality Name,2026 PW GPCI (with 1.0 Floor)***,2026 PE GPCI,2026 MP GPCI
410112,AL,00,ALABAMA,1.000,0.875,0.566
502102,AK,01,ALASKA*,1.500,1.065,0.551
603102,AZ,00,ARIZONA,1.000,0.969,0.856
707102,AR,13,ARKANSAS,1.000,0.859,0.515
801112,CA,54,BAKERSFIELD,1.019,1.096,0.609