$161.46
88368 is the manual morphometric analysis counterpart; 88367 is used when the analysis is automated.
On this page
CMS RVU26D · Effective 2026-10-01
88367 ISH analysis Medicare reimbursement rates in Guam
Automated morphometric analysis of in situ hybridization signals in tissue helps quantify or assess a molecular finding, such as tumor gene amplification. Compare 88367 office and facility rates across CMS payment localities in Guam.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88367 in Guam?
Guam has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$115.63
1 of 1 localities have a supported rate.
Payment area: Hawaii, Guam
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88367: Automated in situ hybridization analysis
Automated morphometric analysis of in situ hybridization signals in tissue helps quantify or assess a molecular finding, such as tumor gene amplification.
This service covers automated morphometric analysis of in situ hybridization signals in a tissue specimen. A pathology laboratory uses imaging equipment and software to assess signal patterns, while a pathologist interprets the findings in the clinical and morphologic context. A familiar application is evaluating HER2 gene amplification in tumor tissue, including breast or gastric specimens, when the assay and analysis method support this code. It represents image-based analysis, not simply the preparation or staining of a probe slide.
Select the code based on the documented analysis method and the applicable CPT distinction between automated and manual analysis. The record should support the specimen analyzed, the in situ hybridization method, the automated analysis performed, and the pathologist’s interpretation. CMS recognizes professional and technical components: report modifier 26 for the interpretation, modifier TC for the equipment and staff, or neither modifier when billing the global service. The CMS fee schedule prices modifiers 26 and TC separately.
CMS billing rules for 88367
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.71 · 23%
- Practice expense (office) RVU2.41 · 77%
- Malpractice RVU0.02 · 1%
4.6K
Medicare services in 2024 · #1930 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88367 compared with similar codes
Office rates for Guam, from the same CMS release.
$143.11
88369 describes manual quantitative or semiquantitative morphometric analysis, rather than the automated analysis represented by 88367.
$69.36
88373 is for automated quantitative or semiquantitative morphometric analysis; 88367 is the automated morphometric analysis code without that specific quantitative or semiquantitative distinction.
$140.45
88364 represents the initial single-probe in situ hybridization stain procedure, not automated morphometric analysis of the resulting signals.
Compare 88367 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Hawaii, Guam →
Office / nonfacility
$115.63
Facility
Unavailable
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How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88367 in Hawaii, Guam.
PPRRVU2026_Oct_nonQPP.csv
11,294
- Code
- 88367
- Physician work
- 0.71
- Practice expense
- 2.41
- Malpractice
- 0.02
GPCI2026.csv
46
- Locality
- Hawaii, Guam
- Physician work
- 1.000
- Practice expense
- 1.137
- Malpractice
- 0.579
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.71 | × 1.000 | 0.7100 |
| Practice expense | 2.41 | × 1.137 | 2.7402 |
| Malpractice | 0.02 | × 0.579 | 0.0116 |
| Total RVUs | 3.4617 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Hawaii, Guam$115.63
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0.71 | 1 |
| Practice expense | 2.41 | 1.137 |
| Malpractice | 0.02 | 0.579 |
(0.71 × 1 + 2.41 × 1.137 + 0.02 × 0.579) × $33.4009 = $115.63
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88367 billing questions
How does this differ from 88368?
88367 represents automated morphometric analysis of in situ hybridization signals. Use 88368 when the morphometric analysis is performed manually.
Is this code for the probe stain itself?
No. It represents automated morphometric analysis of the in situ hybridization signals, rather than the probe stain procedure alone.
When should modifier 26 or TC be used?
Use modifier 26 for the professional interpretation and modifier TC for the technical service, including equipment and staff. Report the global service without either modifier.
What documentation supports reporting 88367?
Document the tissue specimen, in situ hybridization method, automated morphometric analysis performed, and the pathologist’s interpretation.
Is the unit based on the slide or the specimen?
The code is described per specimen. The report should identify the specimen analyzed rather than treating each image or slide as a separate unit automatically.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,29188366,,Insitu hybridization (fish),A,,1.21,6.69,,6.69,NA,0.04,7.94,7.94,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29288366,26,Insitu hybridization (fish),A,,1.21,0.50,,0.50,,0.02,1.73,1.73,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29388366,TC,Insitu hybridization (fish),A,,0.00,6.19,,6.19,NA,0.02,6.21,6.21,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29488367,,Insitu hybridization auto,A,,0.71,2.41,,2.41,NA,0.02,3.14,3.14,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29588367,26,Insitu hybridization auto,A,,0.71,0.21,,0.21,,0.01,0.93,0.93,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29688367,TC,Insitu hybridization auto,A,,0.00,2.20,,2.20,NA,0.01,2.21,2.21,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29788368,,Insitu hybridization manual,A,,0.86,3.48,,3.48,NA,0.03,4.37,4.37,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
4309102,FL,99,REST OF FLORIDA,1.000,0.956,1.503
4410212,GA,01,ATLANTA,1.003,1.016,1.201
4510212,GA,99,REST OF GEORGIA,1.000,0.892,1.192
4601212,HI,01,"HAWAII, GUAM",1.000,1.137,0.579
4702202,ID,00,IDAHO,1.000,0.920,0.473
4806102,IL,16,CHICAGO,1.007,1.005,2.295
4906102,IL,12,EAST ST. LOUIS,1.000,0.920,2.014