$88.51
88342 is the first single-antibody stain on a specimen; 88341 is the add-on for each further single-antibody stain on that specimen and cannot be reported alone.
On this page
CMS RVU26D · Effective 2026-10-01
88342 Antibody stain Medicare reimbursement rates in Indiana
Report 88342 for the first single-antibody immunohistochemical or immunocytochemical stain on each specimen when a pathologist interprets stained tissue or cells. Compare 88342 office and facility rates across CMS payment localities in Indiana.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88342 in Indiana?
Indiana has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$103.54
1 of 1 localities have a supported rate.
Payment area: Indiana
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88342: First single-antibody immunohistochemistry stain per specimen
Report 88342 for the first single-antibody immunohistochemical or immunocytochemical stain on each specimen when a pathologist interprets stained tissue or cells.
Code 88342 covers the first single-antibody immunohistochemical or immunocytochemical stain on a tissue or cytology specimen, such as a cell block. A histology laboratory prepares the stained material, and a pathologist interprets the result to characterize a tumor, identify metastatic carcinoma in a lymph node, or investigate an infectious organism. These services may be performed in hospital, independent, or office-based laboratories.
Report one unit per separately identifiable specimen receiving a single-antibody stain, not per slide or tissue block. Use 88341 for additional single-antibody stains on that specimen and 88344 for a multiplex antibody stain procedure. Controls are included rather than counted as additional units. Documentation should identify the specimen, antibodies, and findings. CMS recognizes a technical component (modifier TC) for stain preparation, reagents, staff, and equipment, and a professional component (modifier 26) for interpretation. An entity performing both reports the global service without a modifier. A pathologist interpreting staining performed by a hospital laboratory generally reports 88342 with modifier 26.
CMS billing rules for 88342
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.68 · 21%
- Practice expense (office) RVU2.60 · 79%
- Malpractice RVU0.02 · 1%
2.4M
Medicare services in 2024 · #72 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88342 compared with similar codes
Office rates for Indiana, from the same CMS release.
$162.23
88344 covers a multiplex antibody stain procedure; 88342 covers the first single-antibody stain on a specimen. A cocktail alone does not establish that a multiplex procedure was performed.
$113.19
Use 88360 when tumor immunostaining is quantitatively or semiquantitatively analyzed by a manual method, such as ER or HER2 scoring; 88342 covers single-antibody staining without that analysis.
$128.26
88346 covers the first single-antibody immunofluorescence stain, which is used in settings such as renal or blistering skin disease evaluation; 88342 covers a nonfluorescent immunohistochemical or immunocytochemical stain.
Compare 88342 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Indiana →
Office / nonfacility
$103.54
Facility
Unavailable
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How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88342 in Indiana.
PPRRVU2026_Oct_nonQPP.csv
11,251
- Code
- 88342
- Physician work
- 0.68
- Practice expense
- 2.60
- Malpractice
- 0.02
GPCI2026.csv
52
- Locality
- Indiana
- Physician work
- 1.000
- Practice expense
- 0.927
- Malpractice
- 0.486
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.68 | × 1.000 | 0.6800 |
| Practice expense | 2.60 | × 0.927 | 2.4102 |
| Malpractice | 0.02 | × 0.486 | 0.0097 |
| Total RVUs | 3.0999 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Indiana$103.54
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0.68 | 1 |
| Practice expense | 2.6 | 0.927 |
| Malpractice | 0.02 | 0.486 |
(0.68 × 1 + 2.6 × 0.927 + 0.02 × 0.486) × $33.4009 = $103.54
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88342 billing questions
How many units of this code can be reported when several antibodies are run on one specimen?
Report one unit of 88342 for the first single-antibody stain on that specimen. Report each additional single-antibody stain on the same specimen with add-on code 88341.
If two separate specimens each receive single-antibody stains, can this code be reported twice?
Yes. Report 88342 once for each separately identifiable specimen receiving a single-antibody stain, with 88341 for additional single-antibody stains on each specimen.
Are control slides billed separately?
No. Positive and negative controls run with the stain are included and are not counted as additional units.
When should 88360 or 88361 be used instead?
Use 88360 for manual or 88361 for computer-assisted quantitative or semiquantitative tumor immunostaining, such as ER, PR, or HER2 scoring. Do not also report 88342 for the same antibody on the same specimen.
Which modifier does a pathologist use when the hospital lab performs the staining?
The pathologist reports modifier 26 for the interpretation; the hospital performs the technical work. An entity performing both components reports the global code without a modifier.
Does a stain with two antibodies on one slide count here?
Use 88344 when the service is a multiplex antibody stain procedure. Combining antibodies in a cocktail does not, by itself, establish that a multiplex procedure was performed.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
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11,24988341,26,Imhchem/imcytchm ea add antb,A,,0.55,0.24,,0.24,,0.01,0.80,0.80,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25088341,TC,Imhchem/imcytchm ea add antb,A,,0.00,2.02,,2.02,NA,0.00,2.02,2.02,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25188342,,Imhchem/imcytchm 1st antb,A,,0.68,2.60,,2.60,NA,0.02,3.30,3.30,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25288342,26,Imhchem/imcytchm 1st antb,A,,0.68,0.29,,0.29,,0.01,0.98,0.98,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25388342,TC,Imhchem/imcytchm 1st antb,A,,0.00,2.31,,2.31,NA,0.01,2.32,2.32,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25488344,,Imhchem/imcytchm ea mlt antb,A,,0.75,4.42,,4.42,NA,0.02,5.19,5.19,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
4906102,IL,12,EAST ST. LOUIS,1.000,0.920,2.014
5006102,IL,15,SUBURBAN CHICAGO,1.007,1.027,1.772
5106102,IL,99,REST OF ILLINOIS,1.000,0.913,1.563
5208102,IN,00,INDIANA,1.000,0.927,0.486
5305102,IA,00,IOWA,1.000,0.915,0.397
5405202,KS,00,KANSAS,1.000,0.904,0.504
5515102,KY,00,KENTUCKY,1.000,0.889,0.915