$156.57
88365 represents the initial single-probe stain on a specimen. Use 88364 for an additional single-probe stain procedure.
On this page
CMS RVU26D · Effective 2026-10-01
88364 ISH probe stain Medicare reimbursement rates in Iowa
Reports an additional single-probe in situ hybridization stain on a specimen after the initial probe procedure, such as an additional FISH probe. Compare 88364 office and facility rates across CMS payment localities in Iowa.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88364 in Iowa?
Iowa has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$117.41
1 of 1 localities have a supported rate.
Payment area: Iowa
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88364: Additional in situ hybridization probe stain
Reports an additional single-probe in situ hybridization stain on a specimen after the initial probe procedure, such as an additional FISH probe.
This code covers an additional single-probe in situ hybridization stain procedure on a specimen after its initial probe stain. A pathology laboratory performs the probe-based testing on tissue or other submitted material, and a pathologist interprets the findings as part of the diagnostic workup. Fluorescence in situ hybridization (FISH) is a familiar example; the additional stain may assess another target on the specimen.
Report the code only with an eligible primary procedure, such as the initial single-probe stain, and count each additional probe stain procedure per specimen. The record should identify the specimen, the additional probe or target, and the testing performed. Medicare treats this as an add-on paid within the primary procedure’s global period. The global service is billed without a component modifier; modifier 26 reports the interpretation, while modifier TC reports the technical work, equipment, and staff. Both modifiers are separately priced under the CMS facts.
CMS billing rules for 88364
- Global period
- Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.68 · 18%
- Practice expense (office) RVU3.09 · 82%
- Malpractice RVU0.02 · 1%
47.5K
Medicare services in 2024 · #800 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88364 compared with similar codes
Office rates for Iowa, from the same CMS release.
$245.40
88366 reports interpretation and a report for in situ hybridization; 88364 represents the additional probe stain procedure itself.
$97.63
88367 reports manual morphometric analysis of in situ hybridization findings, rather than an additional probe stain procedure.
$135.48
88368 reports computer-assisted morphometric analysis; 88364 reports an additional single-probe stain procedure.
Compare 88364 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Iowa →
Office / nonfacility
$117.41
Facility
Unavailable
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How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88364 in Iowa.
PPRRVU2026_Oct_nonQPP.csv
11,285
- Code
- 88364
- Physician work
- 0.68
- Practice expense
- 3.09
- Malpractice
- 0.02
GPCI2026.csv
53
- Locality
- Iowa
- Physician work
- 1.000
- Practice expense
- 0.915
- Malpractice
- 0.397
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.68 | × 1.000 | 0.6800 |
| Practice expense | 3.09 | × 0.915 | 2.8274 |
| Malpractice | 0.02 | × 0.397 | 0.0079 |
| Total RVUs | 3.5153 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Iowa$117.41
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0.68 | 1 |
| Practice expense | 3.09 | 0.915 |
| Malpractice | 0.02 | 0.397 |
(0.68 × 1 + 3.09 × 0.915 + 0.02 × 0.397) × $33.4009 = $117.41
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88364 billing questions
When is this code used instead of the initial-probe code?
Use it for each additional single-probe stain procedure on a specimen after the initial probe procedure. The initial stain is reported with 88365.
Can this code be billed by itself?
No. It is an add-on code and must be reported with an eligible primary procedure, such as the initial probe stain.
How are units counted?
Count each additional single-probe stain procedure per specimen. Document the specimen and the additional probe or target tested.
When should modifier 26 or TC be used?
Use modifier 26 for the professional interpretation or TC for the technical work, equipment, and staff. Without either modifier, the claim represents the global service.
What documentation supports an additional-probe claim?
The record should show which specimen received testing, the additional probe or target, and that the service was an additional stain procedure beyond the initial probe.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,28288362,26,Nerve teasing preparations,A,,2.12,0.98,,0.98,,0.05,3.15,3.15,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,28388362,TC,Nerve teasing preparations,A,,0.00,3.36,,3.36,NA,0.03,3.39,3.39,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,28488363,,Xm archive tissue molec anal,A,,0.36,0.30,,0.08,,0.02,0.68,0.46,0,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,28588364,,Insitu hybridization (fish),A,,0.68,3.09,,3.09,NA,0.02,3.79,3.79,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,28688364,26,Insitu hybridization (fish),A,,0.68,0.26,,0.26,,0.01,0.95,0.95,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,28788364,TC,Insitu hybridization (fish),A,,0.00,2.83,,2.83,NA,0.01,2.84,2.84,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,28888365,,Insitu hybridization (fish),A,,0.86,4.17,,4.17,NA,0.03,5.06,5.06,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
5006102,IL,15,SUBURBAN CHICAGO,1.007,1.027,1.772
5106102,IL,99,REST OF ILLINOIS,1.000,0.913,1.563
5208102,IN,00,INDIANA,1.000,0.927,0.486
5305102,IA,00,IOWA,1.000,0.915,0.397
5405202,KS,00,KANSAS,1.000,0.904,0.504
5515102,KY,00,KENTUCKY,1.000,0.889,0.915
5607202,LA,01,NEW ORLEANS,1.000,0.941,1.136