$119.55
Choose 88373 for computer-assisted morphometric ISH analysis; 88369 represents manual morphometric analysis.
On this page
CMS RVU26D · Effective 2026-10-01
88373 ISH analysis Medicare reimbursement rates in Iowa
Computer-assisted morphometric analysis quantifies or semi-quantifies in situ hybridization findings, such as signal patterns evaluated in tumor tissue. Compare 88373 office and facility rates across CMS payment localities in Iowa.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88373 in Iowa?
Iowa has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$59.51
1 of 1 localities have a supported rate.
Payment area: Iowa
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88373: Computer-assisted morphometric ISH analysis
Computer-assisted morphometric analysis quantifies or semi-quantifies in situ hybridization findings, such as signal patterns evaluated in tumor tissue.
This service uses computer-assisted image analysis to quantify or semi-quantify findings from in situ hybridization (ISH) in a tissue specimen. A pathologist or qualified laboratory professional typically evaluates stained slides with imaging equipment and analysis software. A familiar clinical setting is assessment of HER2-related signals in breast carcinoma tissue; the method applies when the requested ISH findings require morphometric measurement rather than a qualitative read alone.
Select the service based on the computer-assisted morphometric method and the documented assay and specimen. The record should identify the tissue examined, probe or assay, analysis method, measured findings, and resulting interpretation. CMS treats 88373 as an add-on code: report it only with a primary procedure, and payment falls within that procedure’s global period. The service has separately priced professional and technical components: modifier 26 identifies interpretation, modifier TC identifies equipment and staff, and no component modifier represents the global service.
CMS billing rules for 88373
- Global period
- Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.57 · 30%
- Practice expense (office) RVU1.32 · 69%
- Malpractice RVU0.01 · 1%
6.5K
Medicare services in 2024 · #1712 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88373 compared with similar codes
Office rates for Iowa, from the same CMS release.
$97.63
88367 represents automated ISH. 88373 is distinguished by quantitative or semi-quantitative morphometric analysis using computer-assisted technology.
$107.12
88361 is computer-assisted tumor immunohistochemistry analysis. 88373 concerns morphometric analysis of ISH findings, a different assay.
Compare 88373 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Iowa →
Office / nonfacility
$59.51
Facility
Unavailable
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How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88373 in Iowa.
PPRRVU2026_Oct_nonQPP.csv
11,307
- Code
- 88373
- Physician work
- 0.57
- Practice expense
- 1.32
- Malpractice
- 0.01
GPCI2026.csv
53
- Locality
- Iowa
- Physician work
- 1.000
- Practice expense
- 0.915
- Malpractice
- 0.397
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.57 | × 1.000 | 0.5700 |
| Practice expense | 1.32 | × 0.915 | 1.2078 |
| Malpractice | 0.01 | × 0.397 | 0.0040 |
| Total RVUs | 1.7818 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Iowa$59.51
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0.57 | 1 |
| Practice expense | 1.32 | 0.915 |
| Malpractice | 0.01 | 0.397 |
(0.57 × 1 + 1.32 × 0.915 + 0.01 × 0.397) × $33.4009 = $59.51
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88373 billing questions
How does 88373 differ from 88369?
88373 is for computer-assisted morphometric analysis of ISH findings. Use 88369 when the morphometric analysis is performed manually.
Can 88373 be reported by itself?
No. CMS identifies it as an add-on code, so it must be reported with a primary procedure. Payment is within that primary procedure’s global period.
When should modifier 26 or TC be used?
Use modifier 26 for the professional interpretation and modifier TC for the technical service, including equipment and staff. Report the global service without either component modifier.
What documentation supports 88373?
Document the specimen, ISH assay or probe, use of computer-assisted morphometric analysis, measured findings, and interpretation. The record should make clear that the work was quantitative or semi-quantitative.
Is this the same as automated ISH?
Not necessarily. 88373 describes computer-assisted morphometric measurement; an ISH service without that morphometric analysis may be represented by a different code.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,30488371,26,Protein western blot tissue,A,,0.36,0.17,,0.17,,0.01,0.54,0.54,6,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30588372,,Protein analysis w/probe,X,,0.00,0.00,,0.00,,0.00,0.00,0.00,9,XXX,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30688372,26,Protein analysis w/probe,A,,0.36,0.16,,0.16,,0.01,0.53,0.53,6,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30788373,,M/phmtrc alys ishquant/semiq,A,,0.57,1.32,,1.32,NA,0.01,1.90,1.90,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30888373,26,M/phmtrc alys ishquant/semiq,A,,0.57,0.14,,0.14,,0.00,0.71,0.71,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30988373,TC,M/phmtrc alys ishquant/semiq,A,,0.00,1.18,,1.18,NA,0.01,1.19,1.19,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31088374,,M/phmtrc alys ishquant/semiq,A,,0.91,7.04,,7.04,NA,0.02,7.97,7.97,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
5006102,IL,15,SUBURBAN CHICAGO,1.007,1.027,1.772
5106102,IL,99,REST OF ILLINOIS,1.000,0.913,1.563
5208102,IN,00,INDIANA,1.000,0.927,0.486
5305102,IA,00,IOWA,1.000,0.915,0.397
5405202,KS,00,KANSAS,1.000,0.904,0.504
5515102,KY,00,KENTUCKY,1.000,0.889,0.915
5607202,LA,01,NEW ORLEANS,1.000,0.941,1.136