$103.02–$109.19
88342 reports the initial single-antibody stain on a specimen. 88341 reports each additional distinct single-antibody stain on that specimen and is an add-on code.
On this page
CMS RVU26D · Effective 2026-10-01
88341 Immunostain Medicare reimbursement rates in Maine
Report 88341 for each additional distinct single-antibody immunostain on a specimen after its initial single-antibody stain is reported with 88342. Compare 88341 office and facility rates across CMS payment localities in Maine.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88341 in Maine?
Maine has 2 payment localities in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the 2 payment areas shown below, using the same CMS release.
Office / nonfacility
$88.03–$93.39
2 of 2 localities have a supported rate.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88341: Additional single-antibody immunostain per specimen
Report 88341 for each additional distinct single-antibody immunostain on a specimen after its initial single-antibody stain is reported with 88342.
This service covers another single-antibody immunohistochemistry or immunocytochemistry stain on a specimen after its first single-antibody stain. A laboratory applies a distinct antibody, such as a keratin or CD marker, to tissue sections or cytology material. A pathologist interprets the staining to help classify a carcinoma, lymphoma, or other lesion. Hospital pathology departments and independent laboratories perform the staining; the specimen may also have a separately reported surgical pathology examination.
Report one unit for each distinct additional single-antibody stain per specimen, not for each slide or tissue block. Report the initial single-antibody stain on each separately identified specimen with 88342; document the specimen, antibodies tested, and results. Control slides do not generate additional units. As an add-on, 88341 must accompany a primary procedure and is paid within that procedure’s global period. Modifier 26 identifies the pathologist’s interpretation, and modifier TC identifies the laboratory’s staining, reagents, and staff work when components are billed separately. Billing without either modifier identifies the global service.
CMS billing rules for 88341
- Global period
- Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.55 · 20%
- Practice expense (office) RVU2.26 · 80%
- Malpractice RVU0.01 · 0%
3.8M
Medicare services in 2024 · #49 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88341 compared with similar codes
Office rates for Maine, from the same CMS release.
$161.29–$171.78
88344 reports a multiplex procedure producing distinguishable results from multiple antibodies. Report 88341 for an additional separate single-antibody stain.
$112.64–$119.17
88360 reports manual morphometric analysis of a tumor immunostain. Do not also report 88341 for that antibody on the same specimen.
$99.68–$105.85
88350 reports an additional immunofluorescence antibody stain, such as in direct immunofluorescence of renal or skin tissue. 88341 reports an additional immunohistochemistry or immunocytochemistry single-antibody stain.
Compare 88341 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
2 of 2 payment localities
Rest Of Maine →
Office / nonfacility
$88.03
Facility
Unavailable
Southern Maine →
Office / nonfacility
$93.39
Facility
Unavailable
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88341 billing questions
How do I split units between 88342 and 88341 when several specimens are stained?
Report 88342 for the initial single-antibody stain on each separately identified specimen. Report one unit of 88341 for each distinct additional single-antibody stain on that specimen, not for another slide or block stained with the same antibody.
Can 88341 be billed without a primary procedure?
No. It is an add-on code; report it with 88342 for the initial single-antibody stain on the same specimen.
When is a stain reported with 88344 rather than 88341?
Use 88344 for a multiplex stain procedure that produces distinguishable results from multiple antibodies. Use 88341 for an additional, separate single-antibody stain on the specimen.
Can 88341 be reported for the same antibody quantified with 88360 or 88361?
No. Do not also report a qualitative immunostain code for the same antibody on the same specimen when its morphometric analysis is reported with 88360 or 88361.
Which modifier identifies the pathologist’s interpretation when another entity stains the slides?
Report the separately billed interpretation with modifier 26; modifier TC identifies the separately billed technical work. When one entity bills both components, report the global service without either modifier.
Do control slides count as additional units?
No. Positive and negative control slides do not generate additional units of 88341.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,24588334,,Path consltj surg cyto xm ea,A,,0.71,0.89,,0.89,NA,0.01,1.61,1.61,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,24688334,26,Path consltj surg cyto xm ea,A,,0.71,0.33,,0.33,,0.01,1.05,1.05,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,24788334,TC,Path consltj surg cyto xm ea,A,,0.00,0.56,,0.56,NA,0.00,0.56,0.56,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,24888341,,Imhchem/imcytchm ea add antb,A,,0.55,2.26,,2.26,NA,0.01,2.82,2.82,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,24988341,26,Imhchem/imcytchm ea add antb,A,,0.55,0.24,,0.24,,0.01,0.80,0.80,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25088341,TC,Imhchem/imcytchm ea add antb,A,,0.00,2.02,,2.02,NA,0.00,2.02,2.02,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25188342,,Imhchem/imcytchm 1st antb,A,,0.68,2.60,,2.60,NA,0.02,3.30,3.30,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00