$128.00–$146.26
Use 88364 for the initial single-probe staining procedure. Use 88366 for interpretation and reporting of in situ hybridization findings.
On this page
CMS RVU26D · Effective 2026-10-01
88366 FISH interpretation Medicare reimbursement rates in Maryland
Reports the diagnostic interpretation of in situ hybridization findings, such as fluorescent probe results in tumor tissue, for a specific clinical question. Compare 88366 office and facility rates across CMS payment localities in Maryland.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88366 in Maryland?
Maryland has 3 payment localities in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the 3 payment areas shown below, using the same CMS release.
Office / nonfacility
$268.18–$307.31
3 of 3 localities have a supported rate.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Where 88366 pays more and less in Maryland
3 payment localities
$268.18 to $307.31
Surgical pathology
About 88366: In situ hybridization interpretation and report
Reports the diagnostic interpretation of in situ hybridization findings, such as fluorescent probe results in tumor tissue, for a specific clinical question.
A pathologist evaluates in situ hybridization findings, including fluorescent in situ hybridization (FISH) signals in tissue or cytology specimens, and prepares a diagnostic interpretation and report. Oncology specimens may be assessed for gene or chromosome changes relevant to tumor classification or treatment decisions. The report connects the probe findings with the specimen and clinical question; this service is distinct from performing the probe-staining procedure itself.
Report 88366 for the interpretation and report associated with an in situ hybridization study, supported by documentation identifying the specimen, test findings, and diagnostic conclusion. CMS recognizes professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the technical service, and billing without either modifier represents the global service. The professional component reflects the physician’s interpretation; the technical component covers equipment and staff involved in the test.
CMS billing rules for 88366
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU1.21 · 15%
- Practice expense (office) RVU6.69 · 84%
- Malpractice RVU0.04 · 1%
3.2K
Medicare services in 2024 · #2136 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88366 compared with similar codes
Office rates for Maryland, from the same CMS release.
$170.89–$195.47
88365 describes an additional single-probe staining procedure; 88366 describes interpretation and reporting, not an additional stain.
$106.03–$120.56
88367 describes an automated in situ hybridization staining procedure. 88366 is the interpretation-and-report service.
$147.56–$168.32
88368 describes a manual in situ hybridization staining procedure. Choose 88366 for interpretation and reporting of the findings.
Compare 88366 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
3 of 3 payment localities
Baltimore/Surr. Cntys →
Office / nonfacility
$282.48
Facility
Unavailable
Dc + Md/Va Suburbs →
Office / nonfacility
$307.31
Facility
Unavailable
Rest Of Maryland →
Office / nonfacility
$268.18
Facility
Unavailable
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88366 billing questions
How does 88366 differ from the probe-staining codes?
88366 represents interpretation and reporting of in situ hybridization findings. Codes such as 88364 and 88367 describe probe-staining procedures, including whether the procedure is automated.
Can the professional and technical portions be billed separately?
Yes. Modifier 26 identifies the professional interpretation and modifier TC identifies the technical service. Without either modifier, the claim represents the global service.
What documentation supports 88366?
The record should identify the specimen and in situ hybridization findings and include the diagnostic interpretation and report. The report should make clear the clinical conclusion drawn from the probe results.
Is 88366 reported for each probe?
The supplied CMS facts do not specify unit or probe-count instructions. Follow the applicable code-set unit guidance and document the interpreted study.
Is 88366 an add-on code?
The CMS facts supplied for this code do not identify add-on status or a required primary-code pairing.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,28888365,,Insitu hybridization (fish),A,,0.86,4.17,,4.17,NA,0.03,5.06,5.06,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,28988365,26,Insitu hybridization (fish),A,,0.86,0.34,,0.34,,0.01,1.21,1.21,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29088365,TC,Insitu hybridization (fish),A,,0.00,3.83,,3.83,NA,0.02,3.85,3.85,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29188366,,Insitu hybridization (fish),A,,1.21,6.69,,6.69,NA,0.04,7.94,7.94,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29288366,26,Insitu hybridization (fish),A,,1.21,0.50,,0.50,,0.02,1.73,1.73,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29388366,TC,Insitu hybridization (fish),A,,0.00,6.19,,6.19,NA,0.02,6.21,6.21,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29488367,,Insitu hybridization auto,A,,0.71,2.41,,2.41,NA,0.02,3.14,3.14,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00