$119.32–$131.84
88360 covers manual quantitative or semiquantitative tumor IHC assessment; 88361 covers computer-assisted image analysis. Choose according to the method documented for the stain procedure.
On this page
CMS RVU26D · Effective 2026-10-01
88360 Tumor IHC scoring Medicare reimbursement rates in Massachusetts
Manual quantitative or semiquantitative scoring of a tumor immunohistochemical stain, such as ER, PR, HER2, or Ki-67, reported per specimen and single-antibody stain procedure. Compare 88360 office and facility rates across CMS payment localities in Massachusetts.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88360 in Massachusetts?
Massachusetts has 2 payment localities in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the 2 payment areas shown below, using the same CMS release.
Office / nonfacility
$125.42–$139.13
2 of 2 localities have a supported rate.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88360: Manual quantitative tumor immunohistochemistry per antibody
Manual quantitative or semiquantitative scoring of a tumor immunohistochemical stain, such as ER, PR, HER2, or Ki-67, reported per specimen and single-antibody stain procedure.
This service includes immunohistochemical staining of tumor tissue and a pathologist's manual quantitative or semiquantitative assessment, rather than a qualitative interpretation alone. Common uses in breast carcinoma include estrogen and progesterone receptor scoring, HER2 membrane scoring on a 0 to 3+ scale, and the Ki-67 proliferation index. Hospital and independent pathology laboratories perform the staining; a pathologist assesses the stained cells at the microscope on a biopsy or resection specimen.
Report one unit for each single-antibody stain procedure scored manually on each separately evaluated specimen. If computer-assisted image analysis performs the quantitation, report 88361 instead. Do not add a qualitative IHC code for the same antibody stain procedure; qualitative stains using other antibodies may be reported separately when supported. Documentation should identify the specimen, antibody, manual scoring method, and result. CMS prices professional and technical components separately: modifier 26 identifies the pathologist's interpretation, modifier TC identifies the staining and other technical work, and the unmodified code represents both components when furnished by one billing entity.
CMS billing rules for 88360
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.83 · 23%
- Practice expense (office) RVU2.75 · 76%
- Malpractice RVU0.02 · 1%
729.1K
Medicare services in 2024 · #179 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88360 compared with similar codes
Office rates for Massachusetts, from the same CMS release.
$115.05–$127.93
88342 is the initial single-antibody IHC stain procedure on a specimen when assessed qualitatively. Choose 88360 when a tumor antibody stain procedure receives documented manual quantitative or semiquantitative assessment.
$98.42–$109.55
88341 covers an additional single-antibody IHC stain procedure assessed qualitatively and is reported with the initial procedure code. It is not added to 88360 for the same antibody stain procedure.
Compare 88360 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
2 of 2 payment localities
Metropolitan Boston →
Office / nonfacility
$139.13
Facility
Unavailable
Rest Of Massachusetts →
Office / nonfacility
$125.42
Facility
Unavailable
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88360 billing questions
When is 88360 reported instead of 88342?
Use 88360 for documented manual quantitative or semiquantitative tumor IHC assessment, such as an ER percentage or HER2 0 to 3+ score. Use 88342 for the first single-antibody IHC stain procedure on a specimen when the work is a qualitative assessment.
How many units are reported for an ER, PR, and HER2 panel on one breast biopsy?
Report three units if each single-antibody stain procedure is manually scored on that specimen. Count a second separately evaluated specimen separately when those stains are also performed and scored on it.
Can 88342 or 88341 be billed with 88360 for the same antibody?
Do not add a qualitative IHC code for the same antibody stain procedure on the same specimen. Qualitative stains for different antibodies may be reported separately when supported.
What if image analysis software is used to score the stain?
Report 88361 instead of 88360 when computer-assisted image analysis performs the quantitative or semiquantitative assessment. Do not report both for the same stain procedure on the same specimen.
Which modifier does a hospital-based pathologist use?
When the hospital performs the technical work and the pathologist bills only for interpretation, the pathologist reports 88360 with modifier 26. Modifier TC identifies a separately billed technical component; an entity furnishing and billing both components reports the global service without either modifier.
What documentation supports 88360?
The report should identify the specimen and antibody, document manual quantitative or semiquantitative assessment, and give the score or measured result, such as the percentage of positive tumor nuclei.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,27288358,,Analysis tumor,A,,0.93,2.94,,2.94,NA,0.03,3.90,3.90,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,27388358,26,Analysis tumor,A,,0.93,0.43,,0.43,,0.02,1.38,1.38,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,27488358,TC,Analysis tumor,A,,0.00,2.51,,2.51,NA,0.01,2.52,2.52,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,27588360,,Tumor immunohistochem/manual,A,,0.83,2.75,,2.75,NA,0.02,3.60,3.60,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,27688360,26,Tumor immunohistochem/manual,A,,0.83,0.33,,0.33,,0.01,1.17,1.17,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,27788360,TC,Tumor immunohistochem/manual,A,,0.00,2.42,,2.42,NA,0.01,2.43,2.43,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,27888361,,Tumor immunohistochem/comput,A,,0.93,2.48,,2.48,NA,0.02,3.43,3.43,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00