$134.00–$151.95
Q4221 identifies AmnioWrap2. Use Q4225 for Amnio or DermaTL, not merely because both products are billed by square centimeter.
On this page
CMS RVU26D · Effective 2026-10-01
Q4225 Skin substitute Medicare reimbursement rates in Massachusetts
Q4225 reports Amnio or DermaTL wound product by square centimeter when the product is supplied with a qualifying wound-application procedure. Compare Q4225 office and facility rates across CMS payment localities in Massachusetts.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for Q4225 in Massachusetts?
Massachusetts has 2 payment localities in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the 2 payment areas shown below, using the same CMS release.
Office / nonfacility
$134.00–$151.95
2 of 2 localities have a supported rate.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Wound care products
About Q4225: Amnio or DermaTL wound product
Q4225 reports Amnio or DermaTL wound product by square centimeter when the product is supplied with a qualifying wound-application procedure.
Q4225 identifies Amnio or DermaTL, a wound-care tissue product supplied in square-centimeter units. It is used when this specific product is applied to a wound, commonly in outpatient wound care by a physician or other qualified practitioner. The product code identifies the supply; the wound-site application is reported separately with the applicable procedure code.
Report units based on the documented quantity of Amnio or DermaTL supplied, and retain records identifying the product, wound site, and amount used. CMS classifies Q4225 as an add-on code: bill it only with a primary procedure, and its payment is included within that procedure’s global period. CMS also classifies it as technical-component-only; professional interpretation is represented by a separate code rather than included in Q4225.
CMS billing rules for Q4225
- Global period
- Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
- Professional and technical components
- Technical-component-only code: a separate code covers interpretation.
Where the value comes from
- Work RVU0.00 · 0%
- Practice expense (office) RVU3.81 · 100%
- Malpractice RVU0.00 · 0%
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Q4225 compared with similar codes
Office rates for Massachusetts, from the same CMS release.
$134.00–$151.95
Q4223 identifies Dermabind SL Optic, a different product. Q4225 applies to Amnio or DermaTL.
$134.00–$151.95
Q4227 identifies AmnioCore. Choose between it and Q4225 according to the product actually supplied, not the wound location alone.
Compare Q4225 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
2 of 2 payment localities
Metropolitan Boston →
Office / nonfacility
$151.95
Facility
Unavailable
Rest Of Massachusetts →
Office / nonfacility
$134.00
Facility
Unavailable
Need rates for a whole code list?
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Q4225 billing questions
Can Q4225 be billed by itself?
No. CMS identifies Q4225 as an add-on code, so it must be billed with the applicable primary wound-application procedure.
How is the number of units determined?
The code is measured per square centimeter. Document the quantity of Amnio or DermaTL supplied and the wound site receiving it.
Is the wound application included in Q4225?
No. Q4225 identifies the product; report the applicable wound-application procedure separately as the primary service.
Does Q4225 include professional interpretation?
No. CMS classifies Q4225 as technical-component-only and indicates that a separate code covers interpretation.
Can Q4225 be substituted for another amniotic or dermal product code?
No. Select the code matching the specific product supplied; a similar tissue type or wound use does not make product codes interchangeable.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
18,313Q4222,,"Progenamatrix, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,314Q4223,,Dermabind sl optic per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00
18,315Q4224,,Hhf10-p per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,316Q4225,,"Amnio or derma tl, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,317Q4226,,Myown harv prep proc sq cm,E,,0.00,0.00,,0.00,,0.00,0.00,0.00,9,XXX,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00
18,318Q4227,,Amniocore per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,319Q4229,,Cogenex amnio memb per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00