88271
No office rateCytogenetics dna probe
Use 88271 for the DNA-probe testing service. Use 88291 for professional interpretation and reporting of cytogenetic or molecular cytogenetic findings.
On this page
CMS RVU26D · Effective 2026-10-01
88291 Cytogenetic report Medicare reimbursement rates in Minnesota
Report this service for professional interpretation of cytogenetic or molecular cytogenetic study findings, with a written report distinct from laboratory testing. Compare 88291 office and facility rates across CMS payment localities in Minnesota.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88291 in Minnesota?
Minnesota has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$33.04
1 of 1 localities have a supported rate.
Payment area: Minnesota
One mapped payment locality.
Facility setting
$33.04
1 of 1 localities have a supported rate.
Payment area: Minnesota
One mapped payment locality.
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Cytogenetics
About 88291: Cytogenetic study interpretation and report
Report this service for professional interpretation of cytogenetic or molecular cytogenetic study findings, with a written report distinct from laboratory testing.
A qualified interpreting professional reviews results from cytogenetic or molecular cytogenetic testing, interprets the findings, and prepares a report. The studies may involve chromosome analysis or molecular cytogenetic methods such as DNA-probe testing. These services are commonly performed through clinical laboratories serving hospitals, physician practices, and other diagnostic settings; the interpretation may inform evaluation of suspected chromosomal abnormalities or other genetic conditions.
Report 88291 for the interpretation and report, not for specimen processing or the laboratory testing itself. The documentation should support the study reviewed, the interpreting professional’s findings, and the resulting report. CMS identifies 88291 as a professional-component-only code; the technical portion is reported separately using the code for the test performed. Select that technical code according to the method and study, such as DNA-probe testing or chromosome analysis. The professional interpretation and the technical service may therefore appear as separate lines for the same study.
CMS billing rules for 88291
- Professional and technical components
- Professional-component-only code: interpretation and report; a separate code covers the technical portion.
Where the value comes from
- Work RVU0.51 · 52%
- Practice expense (office) RVU0.46 · 46%
- Malpractice RVU0.02 · 2%
60.6K
Medicare services in 2024 · #708 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88291 compared with similar codes
Office rates for Minnesota, from the same CMS release.
88280
No office rateChromosome karyotype study
88280 describes a chromosome-analysis study. 88291 describes interpretation and reporting, rather than the analysis itself.
88299
No office rateUnlisted cytogenetic study
88299 is for an unlisted cytogenetic study when no specific study code fits. It is not a substitute for reporting interpretation of a study.
Compare 88291 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Minnesota →
Office / nonfacility
$33.04
Facility
$33.04
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How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88291 in Minnesota.
PPRRVU2026_Oct_nonQPP.csv
11,195
- Code
- 88291
- Physician work
- 0.51
- Practice expense
- 0.46
- Malpractice
- 0.02
GPCI2026.csv
66
- Locality
- Minnesota
- Physician work
- 1.000
- Practice expense
- 1.029
- Malpractice
- 0.296
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.51 | × 1.000 | 0.5100 |
| Practice expense | 0.46 | × 1.029 | 0.4733 |
| Malpractice | 0.02 | × 0.296 | 0.0059 |
| Total RVUs | 0.9893 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Minnesota$33.04
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0.51 | 1 |
| Practice expense | 0.46 | 1.029 |
| Malpractice | 0.02 | 0.296 |
(0.51 × 1 + 0.46 × 1.029 + 0.02 × 0.296) × $33.4009 = $33.04
Facility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0.51 | 1 |
| Practice expense | 0.46 | 1.029 |
| Malpractice | 0.02 | 0.296 |
(0.51 × 1 + 0.46 × 1.029 + 0.02 × 0.296) × $33.4009 = $33.04
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88291 billing questions
How is 88291 different from 88271?
88291 represents interpretation and reporting. 88271 describes DNA-probe testing, the technical service, when that method is performed.
Does 88291 include laboratory testing or specimen processing?
No. CMS identifies 88291 as professional-component-only; the technical portion is coded separately based on the cytogenetic method performed.
What documentation supports reporting 88291?
Keep the interpreted study results and the written report documenting the professional findings. The record should identify the study being interpreted.
Can 88291 be reported with chromosome analysis?
Yes, when the professional interpretation and report are performed for a chromosome analysis study. Report the applicable technical service separately.
Does 88291 represent a count of cells or probes?
No. It represents the interpretation and report; cell counts or probe details belong to selection of the separate technical study code.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,19288283,,Chromosome banding study,X,,0.00,0.00,,0.00,,0.00,0.00,0.00,9,XXX,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00
11,19388285,,Chromosome count additional,X,,0.00,0.00,,0.00,,0.00,0.00,0.00,9,XXX,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00
11,19488289,,Chromosome study additional,X,,0.00,0.00,,0.00,,0.00,0.00,0.00,9,XXX,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00
11,19588291,,Cyto/molecular report,A,,0.51,0.46,,0.46,,0.02,0.99,0.99,2,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,19688299,,Unlisted cytogenetic study,C,,0.00,0.00,,0.00,,0.00,0.00,0.00,0,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,19788300,,Surgical path gross,A,,0.08,0.39,,0.39,NA,0.02,0.49,0.49,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,19888300,26,Surgical path gross,A,,0.08,0.04,,0.04,,0.01,0.13,0.13,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
6314212,MA,99,REST OF MASSACHUSETTS,1.016,1.053,0.797
6408202,MI,01,DETROIT,1.000,0.965,1.686
6508202,MI,99,REST OF MICHIGAN,1.000,0.913,1.129
6606202,MN,00,MINNESOTA,1.000,1.029,0.296
6707302,MS,00,MISSISSIPPI,1.000,0.861,0.739
6805302,MO,02,METROPOLITAN KANSAS CITY,1.000,0.939,0.977
6905302,MO,01,METROPOLITAN ST. LOUIS,1.000,0.952,1.002