$139.48
88346 is for the first single-antibody immunofluorescence stain. 88350 is for each additional single-antibody stain and must be paired with a primary procedure.
On this page
CMS RVU26D · Effective 2026-10-01
88350 Immunofluorescence Medicare reimbursement rates in Minnesota
Reports each additional single-antibody immunofluorescence stain performed after the first stain, such as in renal or skin biopsy evaluation. Compare 88350 office and facility rates across CMS payment localities in Minnesota.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88350 in Minnesota?
Minnesota has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$108.93
1 of 1 localities have a supported rate.
Payment area: Minnesota
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88350: Additional immunofluorescence antibody stain
Reports each additional single-antibody immunofluorescence stain performed after the first stain, such as in renal or skin biopsy evaluation.
A pathology laboratory performs an additional immunofluorescence stain to detect a specific antibody or immune reactant in tissue. The pathologist interprets the staining pattern and reports the findings. Common settings include evaluation of renal biopsy tissue for immune deposits and direct immunofluorescence studies of skin biopsies when an autoimmune blistering disorder is suspected. Laboratory staff prepare and stain the tissue; the pathologist provides the diagnostic interpretation.
Report 88350 for each additional single-antibody stain after the first stain reported with 88346. The record should identify the tissue studied, the antibodies tested, and the results supporting each stain. This is an add-on code, so it is billed with its primary procedure and paid within that procedure’s global period. Modifier 26 identifies the professional interpretation, while modifier TC identifies the technical work, equipment, and staff; reporting without either modifier represents the global service.
CMS billing rules for 88350
- Global period
- Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.58 · 18%
- Practice expense (office) RVU2.60 · 81%
- Malpractice RVU0.02 · 1%
253.5K
Medicare services in 2024 · #341 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88350 compared with similar codes
Office rates for Minnesota, from the same CMS release.
$112.27
88342 reports the first immunohistochemistry or immunocytochemistry antibody stain. Choose based on the staining method documented, not merely the target antibody.
$177.16
88344 describes a multiple-antibody immunohistochemistry or immunocytochemistry stain procedure; 88350 describes an additional single-antibody immunofluorescence stain.
Compare 88350 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Minnesota →
Office / nonfacility
$108.93
Facility
Unavailable
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How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88350 in Minnesota.
PPRRVU2026_Oct_nonQPP.csv
11,263
- Code
- 88350
- Physician work
- 0.58
- Practice expense
- 2.60
- Malpractice
- 0.02
GPCI2026.csv
66
- Locality
- Minnesota
- Physician work
- 1.000
- Practice expense
- 1.029
- Malpractice
- 0.296
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.58 | × 1.000 | 0.5800 |
| Practice expense | 2.60 | × 1.029 | 2.6754 |
| Malpractice | 0.02 | × 0.296 | 0.0059 |
| Total RVUs | 3.2613 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Minnesota$108.93
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0.58 | 1 |
| Practice expense | 2.6 | 1.029 |
| Malpractice | 0.02 | 0.296 |
(0.58 × 1 + 2.6 × 1.029 + 0.02 × 0.296) × $33.4009 = $108.93
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88350 billing questions
Can 88350 be reported by itself?
No. It is an add-on for additional immunofluorescence stains and is reported with the primary stain code, 88346.
How does 88350 differ from 88346?
88346 represents the first single-antibody immunofluorescence stain. Use 88350 for each additional single-antibody stain in the same service.
When should the laboratory use an immunohistochemistry code instead?
Use the immunohistochemistry or immunocytochemistry code family when the laboratory performs that staining method rather than immunofluorescence. The documented method, not simply the antibody being tested, distinguishes the service.
Can the professional and technical portions be billed separately?
Yes. Modifier 26 identifies the pathologist’s professional interpretation, and modifier TC identifies the technical portion. Without either modifier, the claim represents the global service.
What documentation supports additional units?
Document the tissue examined and each additional antibody stain performed, with findings supporting the interpretation. Report 88350 with 88346 rather than as a standalone service.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,26088348,,Electron microscopy dx,A,,1.47,12.72,,12.72,NA,0.12,14.31,14.31,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,26188348,26,Electron microscopy dx,A,,1.47,0.66,,0.66,,0.03,2.16,2.16,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,26288348,TC,Electron microscopy dx,A,,0.00,12.06,,12.06,NA,0.09,12.15,12.15,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,26388350,,Imfluor ea addl 1antb stn px,A,,0.58,2.60,,2.60,NA,0.02,3.20,3.20,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,26488350,26,Imfluor ea addl 1antb stn px,A,,0.58,0.23,,0.23,,0.01,0.82,0.82,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,26588350,TC,Imfluor ea addl 1antb stn px,A,,0.00,2.37,,2.37,NA,0.01,2.38,2.38,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,26688355,,M/phmtrc alys skeletal musc,A,,1.80,2.37,,2.37,NA,0.03,4.20,4.20,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
6314212,MA,99,REST OF MASSACHUSETTS,1.016,1.053,0.797
6408202,MI,01,DETROIT,1.000,0.965,1.686
6508202,MI,99,REST OF MICHIGAN,1.000,0.913,1.129
6606202,MN,00,MINNESOTA,1.000,1.029,0.296
6707302,MS,00,MISSISSIPPI,1.000,0.861,0.739
6805302,MO,02,METROPOLITAN KANSAS CITY,1.000,0.939,0.977
6905302,MO,01,METROPOLITAN ST. LOUIS,1.000,0.952,1.002