$21.31–$22.23
Use 88387 for macroscopic tissue dissection and preparation. Use 88363 when examining and selecting previously archived tissue for molecular analysis.
On this page
CMS RVU26D · Effective 2026-10-01
88387 Tissue preparation Medicare reimbursement rates in Missouri
Reports gross tissue selection, dissection, and preparation of a specimen for nonmicroscopic analysis, such as a nucleic acid-based molecular study. Compare 88387 office and facility rates across CMS payment localities in Missouri.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88387 in Missouri?
Missouri has 3 payment localities in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the 3 payment areas shown below, using the same CMS release.
Office / nonfacility
$31.06–$32.16
3 of 3 localities have a supported rate.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Where 88387 pays more and less in Missouri
3 payment localities
$31.06 to $32.16
Surgical pathology
About 88387: Macroscopic tissue preparation for molecular analysis
Reports gross tissue selection, dissection, and preparation of a specimen for nonmicroscopic analysis, such as a nucleic acid-based molecular study.
A pathologist examines tissue macroscopically, selects the area needed for a nonmicroscopic analytical study, and dissects and prepares it for testing. A common situation is selecting tumor tissue from a surgical specimen for downstream molecular analysis. The preparation service is distinct from performing or interpreting the molecular assay itself and may take place in a hospital or pathology laboratory.
Report 88387 for the first specimen prepared under this service; code 88388 is used for additional specimens when appropriate. Documentation should identify the tissue and analytical purpose and support the macroscopic selection, dissection, and preparation performed. CMS treats this as a diagnostic test with professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the technical service, and reporting without either modifier represents the global service.
CMS billing rules for 88387
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.60 · 61%
- Practice expense (office) RVU0.36 · 37%
- Malpractice RVU0.02 · 2%
1.6K
Medicare services in 2024 · #2634 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88387 compared with similar codes
Office rates for Missouri, from the same CMS release.
$106.61–$113.77
88380 is for laser microdissection at a microscopic level; 88387 is for macroscopic tissue selection and preparation.
$164.39–$179.62
88381 describes manual microdissection. 88387 describes macroscopic dissection and preparation for nonmicroscopic analysis.
Compare 88387 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
3 of 3 payment localities
Metropolitan Kansas City →
Office / nonfacility
$31.98
Facility
Unavailable
Metropolitan St. Louis →
Office / nonfacility
$32.16
Facility
Unavailable
Rest Of Missouri →
Office / nonfacility
$31.06
Facility
Unavailable
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88387 billing questions
How is 88387 different from 88363?
88387 covers macroscopic dissection and preparation of tissue for a nonmicroscopic study. 88363 concerns examining and selecting tissue already in an archive for molecular analysis.
When is 88388 used instead?
88387 represents preparation of the first specimen; 88388 is the related code for each additional specimen when the service is performed on more than one.
Does 88387 include the molecular assay?
No. It represents the gross tissue selection and preparation, not the downstream molecular analysis.
Which modifiers identify the components?
Use modifier 26 for the professional interpretation and TC for the technical service. Without either modifier, the claim represents the global service.
How does this differ from microdissection?
88387 describes macroscopic selection and preparation. Codes 88380 and 88381 describe laser and manual microdissection, respectively.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,32088381,,Microdissection manual,A,,0.52,5.05,,5.05,NA,0.05,5.62,5.62,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,32188381,26,Microdissection manual,A,,0.52,0.13,,0.13,,0.01,0.66,0.66,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,32288381,TC,Microdissection manual,A,,0.00,4.92,,4.92,NA,0.04,4.96,4.96,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,32388387,,Macroscopic xm dsj&prep tiss,A,,0.60,0.36,,0.36,NA,0.02,0.98,0.98,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,32488387,26,Macroscopic xm dsj&prep tiss,A,,0.60,0.15,,0.15,,0.01,0.76,0.76,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,32588387,TC,Macroscopic xm dsj&prep tiss,A,,0.00,0.21,,0.21,NA,0.01,0.22,0.22,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,32688399,,Unlisted surgical path px,C,,0.00,0.00,,0.00,NA,0.00,0.00,0.00,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00