$98.27
88377 describes quantitative or semiquantitative morphometric analysis of ISH findings per specimen. Consider 88367 when the service is computer-assisted ISH but is not the morphometric analysis described here.
On this page
CMS RVU26D · Effective 2026-10-01
88377 ISH analysis Medicare reimbursement rates in Nebraska
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization findings for a probe in a tissue specimen. Compare 88377 office and facility rates across CMS payment localities in Nebraska.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88377 in Nebraska?
Nebraska has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$357.33
1 of 1 localities have a supported rate.
Payment area: Nebraska
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88377: Computer-assisted ISH morphometric analysis
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization findings for a probe in a tissue specimen.
This service uses computer-assisted image analysis to quantify or semiquantify in situ hybridization findings for a probe in a tissue specimen. A pathologist typically reviews the stained tissue and image-analysis results in a pathology laboratory, such as when evaluating tumor cells for a molecular marker. The analysis supplements the underlying ISH test by providing a measured assessment of the probe signal rather than a visual interpretation alone.
Report the service when the specimen undergoes the specified morphometric analysis, and identify the specimen, probe, method, and analyzed findings in the pathology record. The code is reported per specimen; the probe and analysis performed should be clear enough to support the reported service. CMS recognizes professional and technical components: modifier 26 represents interpretation, modifier TC represents equipment and staff, and reporting without either modifier represents the global service.
CMS billing rules for 88377
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU1.37 · 12%
- Practice expense (office) RVU10.09 · 88%
- Malpractice RVU0.04 · 0%
133K
Medicare services in 2024 · #483 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88377 compared with similar codes
Office rates for Nebraska, from the same CMS release.
$107.77
88361 is computer-assisted morphometric analysis of tumor immunohistochemistry. This code is for morphometric analysis of in situ hybridization findings.
$120.38
Both codes concern morphometric ISH analysis. Compare the code descriptors and documented method to determine which service was performed.
Compare 88377 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Nebraska →
Office / nonfacility
$357.33
Facility
Unavailable
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How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88377 in Nebraska.
PPRRVU2026_Oct_nonQPP.csv
11,314
- Code
- 88377
- Physician work
- 1.37
- Practice expense
- 10.09
- Malpractice
- 0.04
GPCI2026.csv
72
- Locality
- Nebraska
- Physician work
- 1.000
- Practice expense
- 0.923
- Malpractice
- 0.378
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 1.37 | × 1.000 | 1.3700 |
| Practice expense | 10.09 | × 0.923 | 9.3131 |
| Malpractice | 0.04 | × 0.378 | 0.0151 |
| Total RVUs | 10.6982 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Nebraska$357.33
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 1.37 | 1 |
| Practice expense | 10.09 | 0.923 |
| Malpractice | 0.04 | 0.378 |
(1.37 × 1 + 10.09 × 0.923 + 0.04 × 0.378) × $33.4009 = $357.33
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88377 billing questions
When is this code preferable to a general ISH service?
Use it when the service includes computer-assisted quantitative or semiquantitative morphometric analysis of ISH findings. A routine ISH service without that morphometric analysis is a different service.
What should the pathology record identify?
Document the specimen and probe, the computer-assisted morphometric method, and the analysis results. The record should support that the reported work was performed for that specimen.
How do modifiers 26 and TC affect reporting?
Modifier 26 reports the professional interpretation, and modifier TC reports the technical service involving equipment and staff. Without either modifier, the claim represents the global service.
Is the service reported per probe or per specimen?
The code descriptor identifies analysis for each probe and specifies reporting per specimen. Keep the probe and specimen details distinct in the documentation.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,31188374,26,M/phmtrc alys ishquant/semiq,A,,0.91,0.26,,0.26,,0.01,1.18,1.18,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31288374,TC,M/phmtrc alys ishquant/semiq,A,,0.00,6.78,,6.78,NA,0.01,6.79,6.79,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31388375,,Optical endomicroscpy interp,A,,0.89,0.41,,0.41,,0.05,1.35,1.35,2,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31488377,,M/phmtrc alys ishquant/semiq,A,,1.37,10.09,,10.09,NA,0.04,11.50,11.50,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31588377,26,M/phmtrc alys ishquant/semiq,A,,1.37,0.44,,0.44,,0.01,1.82,1.82,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31688377,TC,M/phmtrc alys ishquant/semiq,A,,0.00,9.65,,9.65,NA,0.03,9.68,9.68,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31788380,,Microdissection laser,A,,1.11,2.37,,2.37,NA,0.04,3.52,3.52,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
6905302,MO,01,METROPOLITAN ST. LOUIS,1.000,0.952,1.002
7005302,MO,99,REST OF MISSOURI,1.000,0.862,0.974
7103202,MT,01,MONTANA**,1.000,1.000,0.998
7205402,NE,00,NEBRASKA,1.000,0.923,0.378
7301312,NV,00,NEVADA**,1.000,1.001,0.833
7414312,NH,40,NEW HAMPSHIRE,1.000,1.041,0.875
7512402,NJ,01,NORTHERN NJ,1.063,1.160,1.068