$108.55–$126.98
88342 is for the initial single-antibody stain procedure on a specimen. This code is for a multiplex procedure in which multiple antibodies are applied together.
On this page
CMS RVU26D · Effective 2026-10-01
88344 Immunostain Medicare reimbursement rates in Virginia
Report this service for a tissue or cell specimen stained with multiple antibodies together in one multiplex procedure for diagnostic evaluation. Compare 88344 office and facility rates across CMS payment localities in Virginia.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88344 in Virginia?
Virginia has 2 payment localities in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the 2 payment areas shown below, using the same CMS release.
Office / nonfacility
$170.64–$201.06
2 of 2 localities have a supported rate.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88344: Multiplex immunostain per specimen
Report this service for a tissue or cell specimen stained with multiple antibodies together in one multiplex procedure for diagnostic evaluation.
This service covers a multiplex immunohistochemical or immunocytochemical stain performed on a tissue or cell specimen. Unlike separate single-antibody stains, a multiplex procedure applies multiple antibodies within the same staining process, allowing a pathologist to assess markers together, such as their presence in the same tumor cells. Pathology laboratories commonly perform the technical work on biopsy, resection, or cytology material, with a pathologist interpreting the findings as part of the diagnostic evaluation.
Report the code for each multiplex stain procedure on each specimen; the unit is not based on the number of antibodies within the multiplex. Documentation should identify the specimen, the multiplex staining procedure and antibodies used, and the diagnostic interpretation. When the service is split, modifier 26 identifies the professional interpretation and modifier TC identifies the technical work, including equipment and staff. Reporting without either modifier represents the global service.
CMS billing rules for 88344
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.75 · 14%
- Practice expense (office) RVU4.42 · 85%
- Malpractice RVU0.02 · 0%
212.6K
Medicare services in 2024 · #373 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88344 compared with similar codes
Office rates for Virginia, from the same CMS release.
$92.81–$108.66
88341 covers an additional single-antibody stain procedure after the initial one. This code covers a multiplex stain procedure, not an additional antibody in a series of separate stains.
$118.49–$138.17
88360 applies to tumor immunohistochemistry with manual quantitative analysis. Use this code for a multiplex staining procedure when that specified quantitative-analysis service is not being reported instead.
$112.96–$131.06
88361 applies to tumor immunohistochemistry with computer-assisted quantitative analysis. This code describes a multiplex staining procedure rather than that quantitative-analysis service.
Compare 88344 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
2 of 2 payment localities
Dc + Md/Va Suburbs →
Office / nonfacility
$201.06
Facility
Unavailable
Virginia →
Office / nonfacility
$170.64
Facility
Unavailable
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88344 billing questions
How is this different from 88342 or 88341?
Use this code when multiple antibodies are applied together in one multiplex staining procedure. Codes 88342 and 88341 apply to single-antibody stain procedures.
Are units based on the number of antibodies?
No. Report per specimen for each multiplex antibody stain procedure, not once for every antibody included in that procedure.
Can the professional and technical services be billed separately?
Yes. Modifier 26 reports the professional interpretation, and modifier TC reports the technical work. Without a modifier, the claim represents the global service.
What documentation supports a multiplex stain claim?
Record the specimen, the multiplex procedure and antibodies used, and the pathologist’s diagnostic interpretation. The record should support that the antibodies were used together in a multiplex procedure rather than as separate single-antibody stains.
When should a tumor immunohistochemistry code be considered instead?
For tumor marker testing that involves the specified quantitative analysis, compare this service with 88360 for manual analysis or 88361 for computer-assisted analysis.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,25188342,,Imhchem/imcytchm 1st antb,A,,0.68,2.60,,2.60,NA,0.02,3.30,3.30,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25288342,26,Imhchem/imcytchm 1st antb,A,,0.68,0.29,,0.29,,0.01,0.98,0.98,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25388342,TC,Imhchem/imcytchm 1st antb,A,,0.00,2.31,,2.31,NA,0.01,2.32,2.32,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25488344,,Imhchem/imcytchm ea mlt antb,A,,0.75,4.42,,4.42,NA,0.02,5.19,5.19,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25588344,26,Imhchem/imcytchm ea mlt antb,A,,0.75,0.32,,0.32,,0.01,1.08,1.08,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25688344,TC,Imhchem/imcytchm ea mlt antb,A,,0.00,4.10,,4.10,NA,0.01,4.11,4.11,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,25788346,,Imfluor 1st 1antb stain px,A,,0.72,3.35,,3.35,NA,0.03,4.10,4.10,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00