$63.37
88369 represents the initial single-probe stain procedure in this morphometric analysis series; 88373 represents each additional single-probe stain procedure.
On this page
CMS RVU26D · Effective 2026-10-01
88369 ISH morphometry Medicare reimbursement rates in Wyoming
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization, such as probe-based FISH testing. Compare 88369 office and facility rates across CMS payment localities in Wyoming.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88369 in Wyoming?
Wyoming has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$128.75
1 of 1 localities have a supported rate.
Payment area: Wyoming**
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88369: Computer-assisted ISH morphometric analysis
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization, such as probe-based FISH testing.
This service uses computer-assisted image analysis to quantify or semiquantify signals in tissue cells examined by in situ hybridization, including fluorescence in situ hybridization (FISH). A pathologist or laboratory specialist may evaluate probe signals to assess a molecular finding such as gene amplification in a tumor specimen. It is distinct from simply performing or interpreting a routine histologic stain; the work is the morphometric analysis of the ISH result.
Report 88369 as an add-on with the required primary procedure, not by itself; CMS pays it within that procedure’s global period. The record should identify the specimen and probe, describe the computerized quantitative or semiquantitative analysis, and support the reported interpretation. Modifier 26 identifies the professional interpretation, while modifier TC identifies the technical work, including equipment and staff. Reporting without either modifier represents the global service.
CMS billing rules for 88369
- Global period
- Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.68 · 18%
- Practice expense (office) RVU3.16 · 82%
- Malpractice RVU0.02 · 1%
15.3K
Medicare services in 2024 · #1246 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88369 compared with similar codes
Office rates for Wyoming, from the same CMS release.
$266.03
88374 is for morphometric analysis of a multiplex probe stain procedure, rather than the single-probe stain procedure represented by 88369.
$114.39
88361 is computer-assisted morphometric analysis of tumor immunohistochemistry. Choose 88369 when the analysis is of in situ hybridization.
Compare 88369 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Wyoming** →
Office / nonfacility
$128.75
Facility
Unavailable
Need rates for a whole code list?
Fee-sheet and API access are in early access. Tell us which codes and locations your team needs.
How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88369 in Wyoming**.
PPRRVU2026_Oct_nonQPP.csv
11,300
- Code
- 88369
- Physician work
- 0.68
- Practice expense
- 3.16
- Malpractice
- 0.02
GPCI2026.csv
112
- Locality
- Wyoming**
- Physician work
- 1.000
- Practice expense
- 1.000
- Malpractice
- 0.740
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.68 | × 1.000 | 0.6800 |
| Practice expense | 3.16 | × 1.000 | 3.1600 |
| Malpractice | 0.02 | × 0.740 | 0.0148 |
| Total RVUs | 3.8548 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Wyoming**$128.75
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0.68 | 1 |
| Practice expense | 3.16 | 1 |
| Malpractice | 0.02 | 0.74 |
(0.68 × 1 + 3.16 × 1 + 0.02 × 0.74) × $33.4009 = $128.75
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88369 billing questions
Can 88369 be reported by itself?
No. CMS identifies it as an add-on code, so it must be billed with a primary procedure and is paid within that procedure’s global period.
When should 88369 be distinguished from 88373?
88369 is for the initial single-probe stain procedure in this morphometric analysis series. 88373 is for each additional single-probe stain procedure.
How are modifiers 26 and TC used?
Use modifier 26 for the professional interpretation and modifier TC for the technical service. Without either modifier, the claim represents the global service.
What documentation supports 88369?
Document the specimen and probe evaluated, the computer-assisted quantitative or semiquantitative analysis performed, and the resulting interpretation.
Is 88369 a test for routine immunohistochemistry?
No. It describes morphometric analysis of in situ hybridization. Tumor immunohistochemistry analysis is represented by a different code family.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,29788368,,Insitu hybridization manual,A,,0.86,3.48,,3.48,NA,0.03,4.37,4.37,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29888368,26,Insitu hybridization manual,A,,0.86,0.33,,0.33,,0.01,1.20,1.20,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29988368,TC,Insitu hybridization manual,A,,0.00,3.15,,3.15,NA,0.02,3.17,3.17,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30088369,,M/phmtrc alysishquant/semiq,A,,0.68,3.16,,3.16,NA,0.02,3.86,3.86,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30188369,26,M/phmtrc alysishquant/semiq,A,,0.68,0.27,,0.27,,0.01,0.96,0.96,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30288369,TC,M/phmtrc alysishquant/semiq,A,,0.00,2.89,,2.89,NA,0.01,2.90,2.90,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30388371,,Protein western blot tissue,X,,0.00,0.00,,0.00,,0.00,0.00,0.00,9,XXX,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00
10902402,WA,99,REST OF WASHINGTON,1.013,1.053,0.761
11011402,WV,16,WEST VIRGINIA,1.000,0.869,1.431
11106302,WI,00,WISCONSIN,1.000,0.958,0.308
11203602,WY,21,WYOMING**,1.000,1.000,0.740
113"MAC Assignments as of November 22, 2023",,,,,,
114,,,,,,
115*Work GPCI reflects a 1.5 floor in Alaska established by the MIPPA.,,,,,,