CPT code 0334U: Tumor sequencing, 84 or more genes2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Report this targeted DNA analysis of formalin-fixed solid-tumor tissue for sequencing of 84 or more genes and assessment of genomic findings.
Medicare pays $3,500.00 for 0334U under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$3,500.00
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2023
- +19.9%
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 0334U covers
0334U identifies a proprietary laboratory analysis of DNA from formalin-fixed, paraffin-embedded solid-tumor tissue. The targeted sequencing examines 84 or more genes for sequence variants, gene copy-number amplifications, gene rearrangements, microsatellite instability, and tumor mutational burden. A laboratory reports the assay’s genomic findings for oncology evaluation. The code describes a specific solid-tumor genomic analysis, not simply a gene count.
Medicare pays 0334U under the CLFS at one national amount, with the same payment across localities and no office-versus-facility adjustment. The 2026 national amount is $3,500.00, unchanged from 2025. The code is paid through the CLFS, not the physician fee schedule.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 0334U
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 0334U. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Not on the physician fee schedule
The physician fee schedule doesn’t list 0334U: Medicare pays the test only from the CLFS.
0334U on the lab fee schedule since 2022
0334U · CLFS 2026 Q4 (current)
$3,500.00
Up 19.9% from $2,919.60 in 2023
Every change on file
- Jan 1, 2025 · CLFS 2025 Q1MAC-priced → $3,500.00
- Jan 1, 2024 · CLFS 2024 Q1$2,919.60 → MAC-priced
- Jan 1, 2023 · CLFS 2023 Q1MAC-priced → $2,919.60
17 quarterly CLFS releases on file, first CLFS 2022 Q4. A code missing from a quarter wasn’t on that release.
0334U compared with similar tests
- 81455Tumor genomic panel51+ genes, DNA or DNA/RNA$2,919.60
- 81455 describes a general targeted panel of 51 or more genes for solid-organ or hematolymphoid neoplasms. 0334U identifies a specific proprietary solid-tumor analysis of 84 or more genes.
- 81445Tumor gene panel5–50 genes, DNA or DNA/RNA$597.91
- 81445 describes a general targeted panel of 5–50 genes for solid-organ tumors. 0334U identifies a specific proprietary analysis of 84 or more genes.
0334U billing questions
What findings does 0334U assess?
It analyzes tumor DNA across 84 or more genes for sequence variants, copy-number amplifications, gene rearrangements, microsatellite instability, and tumor mutational burden.
Which specimen is used?
The analysis uses DNA from formalin-fixed, paraffin-embedded solid-tumor tissue.
How does 0334U differ from 81455?
0334U identifies a proprietary solid-tumor analysis of 84 or more genes. Code 81455 describes a targeted panel of 51 or more genes for solid-organ or hematolymphoid neoplasms; select the code that matches the service performed.
Does Medicare pay 0334U through the physician fee schedule?
No. Medicare pays 0334U through the CLFS at one national amount across localities, without an office-versus-facility adjustment.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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