CPT code 0336U: Parent genome, comparator genome2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Whole-genome sequencing of a parent’s blood or saliva provides a comparator for categorizing variants during evaluation of a suspected rare constitutional or inherited disorder.
Medicare pays $2,574.65 for 0336U under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$2,574.65
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2023
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 0336U covers
This service sequences a parent’s genome as a comparator in the evaluation of a suspected constitutional or inherited rare disease. The analysis can identify and categorize small sequence changes, copy number changes, deletions, duplications, mobile element insertions, uniparental disomy, inversions, aneuploidy, mitochondrial findings, and short tandem repeat expansions. Blood or saliva may be used. The comparator helps interpret findings from the affected individual’s genome; this code represents the parent’s genome analysis, not the proband’s test.
Report one unit for each comparator genome analyzed. Medicare pays the service under the CLFS at one national amount, with no geographic or office-versus-facility adjustment. The 2026 national CLFS amount is $2,574.65, unchanged from 2023 through 2025.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 0336U
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 0336U. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Not on the physician fee schedule
The physician fee schedule doesn’t list 0336U: Medicare pays the test only from the CLFS.
0336U on the lab fee schedule since 2022
0336U · CLFS 2026 Q4 (current)
$2,574.65
Unchanged since Jan 1, 2023
Every change on file
- Jan 1, 2023 · CLFS 2023 Q1MAC-priced → $2,574.65
17 quarterly CLFS releases on file, first CLFS 2022 Q4. A code missing from a quarter wasn’t on that release.
0336U compared with similar tests
- 0335UFetal genome testRare disease analysis$5,224.60
- 0335U is the related rare-disease whole-genome service for a fetal sample. 0336U analyzes a parent’s genome as a comparator.
- 81425Genome sequencingConstitutional or heritable disorders$5,031.20
- 81425 represents whole-genome sequencing of the proband. 0336U is for each parent comparator genome, which may be analyzed alongside the proband.
- 81426Genome sequencingEach comparator genome$2,709.95
- 81426 reports comparator-genome sequencing under the genome-analysis code set; 0336U identifies a specific rare-disease comparator-genome laboratory analysis.
- 81416Exome sequencingEach comparator exome$12,000.00
- 81416 covers comparator exome sequencing. 0336U is for whole-genome sequencing of a parent comparator.
0336U billing questions
When is this code reported instead of a proband genome code?
Report 0336U for each parent’s comparator genome. The affected individual’s genome analysis is a separate service.
How many units are reported?
Report one unit for each comparator genome analyzed. A second parent’s genome is a separate comparator.
Can 0336U be reported with the proband’s genome analysis?
Yes. Parent comparator sequencing may be performed alongside proband genome analysis to help interpret the proband’s findings.
What specimens are used?
The service uses blood or saliva from the parent whose genome is being analyzed.
How does Medicare pay for 0336U?
Medicare pays 0336U under the CLFS at one national amount, without geographic or office-versus-facility adjustment.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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