CPT code 0341U: Fetal DNA test, products of conception2026 Medicare lab fee · Clinical Laboratory Fee Schedule
DNA sequencing of fetal material from products of conception evaluates chromosome abnormalities and reports findings such as aneuploidy, mosaicism, or segmental changes.
Medicare pays $1,900.20 for 0341U under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$1,900.20
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2024
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 0341U covers
0341U identifies fetal DNA sequencing performed on products of conception to assess chromosomal abnormalities. The assay characterizes fetal chromosome findings in pregnancy tissue. Results may report a normal euploid profile, monosomy, trisomy, mosaicism, partial deletion or duplication, or segmental aneuploidy. These are result categories within the sequencing analysis, not separate services. Reported findings include chromosome-number changes and partial or segmental chromosome losses or gains.
Report 0341U for the sequencing analysis; chromosome findings are part of its result, not separate services. Medicare pays 0341U through the CLFS at one national amount across localities, without geographic or office/facility adjustments. The 2026 national amount is $1,900.20, unchanged since 2024. Medicare pays this code only through the CLFS.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 0341U
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 0341U. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Not on the physician fee schedule
The physician fee schedule doesn’t list 0341U: Medicare pays the test only from the CLFS.
0341U on the lab fee schedule since 2022
0341U · CLFS 2026 Q4 (current)
$1,900.20
Unchanged since Jan 1, 2024
Every change on file
- Jan 1, 2024 · CLFS 2024 Q1MAC-priced → $1,900.20
17 quarterly CLFS releases on file, first CLFS 2022 Q4. A code missing from a quarter wasn’t on that release.
0341U compared with similar tests
- 81229Chromosomal microarrayCopy number and SNP analysis$1,160.00
- 81229 describes constitutional chromosomal microarray analysis. 0341U is fetal DNA sequencing for products of conception.
- 88262Chromosome analysis15–20 cells, two karyotypes$125.49
- 88262 is conventional chromosome analysis with banding. 0341U analyzes fetal DNA from products of conception by sequencing.
0341U billing questions
What specimen is associated with 0341U?
The analysis uses fetal DNA from products of conception. It reports chromosome findings from that pregnancy tissue.
Do chromosome findings generate separate units?
No. Findings such as trisomy, mosaicism, or a segmental change are result categories of the analysis, not separately described services.
How does this differ from chromosome analysis by karyotype?
0341U is fetal DNA sequencing. Conventional chromosome analysis uses a cytogenetic method to examine chromosomes.
Can a physician bill a separate interpretation with modifier 26?
No. Medicare pays 0341U only through the CLFS.
How does Medicare price 0341U?
Medicare pays one national CLFS amount across localities, with no geographic or office/facility adjustment.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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