CPT code 0576U: Liver rejection assay, cfDNA and 56-gene expression2026 Medicare lab fee · Clinical Laboratory Fee Schedule
This combined plasma and whole-blood molecular assay estimates rejection risk in liver transplant recipients using donor-derived cfDNA and gene expression.
Medicare pays $3,240.00 for 0576U under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$3,240.00
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2026
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 0576U covers
This proprietary assay evaluates liver allograft rejection risk using two molecular measurements: donor-derived cell-free DNA in plasma analyzed by whole-genome next-generation sequencing, and expression profiling of 56 genes in whole blood by multiplex real-time PCR. A combined algorithm reports a rejection risk score. It is used in transplantation medicine for assessment of liver transplant recipients.
Report 0576U for this combined assay and its algorithmic risk score. Medicare pays the code through the Clinical Laboratory Fee Schedule (CLFS), at one national amount that applies across states and localities without geographic adjustment or an office-versus-facility difference. The 2026 national CLFS amount is $3,240.00. The code is paid only through the CLFS and has no physician fee schedule payment row.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 0576U
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 0576U. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Not on the physician fee schedule
The physician fee schedule doesn’t list 0576U: Medicare pays the test only from the CLFS.
0576U on the lab fee schedule since 2025
0576U · CLFS 2026 Q4 (current)
$3,240.00
Unchanged since Jan 1, 2026
Every change on file
- Jan 1, 2026 · CLFS 2026 Q1MAC-priced → $3,240.00
5 quarterly CLFS releases on file, first CLFS 2025 Q4. A code missing from a quarter wasn’t on that release.
0576U compared with similar tests
- 0575ULiver rejection testFour-gene RT-PCR risk$380.00
- Both address liver allograft rejection assessment, but 0576U combines plasma donor-derived cfDNA sequencing with 56-gene expression profiling; 0575U uses a four-gene real-time PCR assay.
- 81595Heart transplant testRejection-risk score$3,240.00
- 81595 is a gene-expression rejection-risk assay for heart transplant recipients. It is not the liver allograft assay reported with 0576U.
0576U billing questions
How does 0576U differ from 0575U?
0576U combines plasma donor-derived cfDNA sequencing with 56-gene expression profiling to produce a rejection risk score. 0575U is a liver-transplant assay using real-time PCR of four genes.
What measurements are included in 0576U?
The assay combines donor-derived cell-free DNA analysis in plasma with 56-gene expression profiling in whole blood. Its algorithm reports a rejection risk score.
Which Medicare fee schedule pays 0576U?
Medicare pays 0576U through the CLFS. The code has no physician fee schedule payment row.
Does the CLFS amount vary by locality or place of service?
No. Medicare sets one national CLFS amount for 0576U, applicable across localities without geographic or office-versus-facility adjustment.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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