CPT code 0582U: Rapid genome test, variant reporting2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Rapid whole-genome sequencing of blood, saliva, or tissue reports DNA variants in testing for rare constitutional or hereditary disorders.
Medicare pays $7,582.20 for 0582U under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$7,582.20
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2026
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 0582U covers
This proprietary laboratory analysis performs rapid whole-genome DNA sequencing for rare constitutional or hereditary disorders. It uses blood, saliva, or tissue and reports single-nucleotide variants, insertions or deletions, and copy-number variations. The code identifies the sequencing assay and its reported genomic findings.
Report 0582U for the described rapid whole-genome assay. It is distinct from exome sequencing and from re-evaluation or reanalysis of previously obtained exome data. Medicare pays the code under the CLFS at one national amount that applies across states and localities, without geographic adjustment or an office-versus-facility difference. The 2026 national CLFS amount is $7,582.20. The code is paid only through the CLFS, with no physician fee schedule row.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 0582U
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 0582U. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Not on the physician fee schedule
The physician fee schedule doesn’t list 0582U: Medicare pays the test only from the CLFS.
0582U on the lab fee schedule since 2025
0582U · CLFS 2026 Q4 (current)
$7,582.20
Unchanged since Jan 1, 2026
Every change on file
- Jan 1, 2026 · CLFS 2026 Q1MAC-priced → $7,582.20
5 quarterly CLFS releases on file, first CLFS 2025 Q4. A code missing from a quarter wasn’t on that release.
0582U compared with similar tests
- 81415Exome analysisInitial sequence analysis$4,780.00
- 81415 describes exome sequence analysis. 0582U describes rapid whole-genome sequencing with the specified variant types reported.
- 81416Exome sequencingEach comparator exome$12,000.00
- 81416 concerns re-evaluation of previously obtained exome sequence data, rather than the rapid whole-genome assay reported under 0582U.
- 81417Exome re-evaluationPreviously obtained sequence$320.00
- 81417 concerns reanalysis of previously obtained exome sequence data, rather than performing the rapid whole-genome assay reported under 0582U.
0582U billing questions
Which specimens are associated with 0582U?
The assay uses blood, saliva, or tissue.
What kinds of variants does 0582U report?
It reports single-nucleotide variants, insertions or deletions, and copy-number variations.
How does 0582U differ from exome sequencing?
0582U describes rapid whole-genome sequencing. Code 81415 describes exome sequence analysis.
Does Medicare pay a separate physician interpretation for 0582U?
The code is paid through the CLFS only and has no physician fee schedule row for a separate interpretation component.
Does the CLFS amount vary by location or setting?
No. One national amount applies across states and localities, without geographic adjustment or an office-versus-facility difference.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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