CPT code 0584U: Prion test, qualitative CSF detection2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Qualitative CSF testing detects prion protein by a conformational-conversion method when clinicians evaluate suspected prion disease.
Medicare pays $540.99 for 0584U under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$540.99
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2026
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 7 sections
What 0584U covers
This proprietary laboratory analysis detects prion protein in cerebrospinal fluid (CSF) using quaking-induced conformational conversion (QUIC), a method based on protein conversion. It produces a qualitative result rather than a measured concentration. Clinicians order the test when evaluating suspected prion disease, and the laboratory performing the assay reports the result. This code identifies a specific CSF prion test, not a general CSF protein measurement.
Report 0584U for this qualitative CSF prion test. Medicare pays the code under the CLFS at one national amount, with no geographic or office-versus-facility adjustment; the 2026 national amount is $540.99. Medicare pays this code through the CLFS only, with no physician fee schedule payment.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 0584U
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 0584U. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Not on the physician fee schedule
The physician fee schedule doesn’t list 0584U: Medicare pays the test only from the CLFS.
0584U on the lab fee schedule since 2025
0584U · CLFS 2026 Q4 (current)
$540.99
Unchanged since Jan 1, 2026
Every change on file
- Jan 1, 2026 · CLFS 2026 Q1MAC-priced → $540.99
5 quarterly CLFS releases on file, first CLFS 2025 Q4. A code missing from a quarter wasn’t on that release.
0584U compared with similar tests
- 83520Quantitative immunoassayNot otherwise specified$17.27
- 83520 describes a quantitative or semiquantitative immunoassay. 0584U is a qualitative CSF prion test using QUIC.
- 84182Western blotImmunological band identification$29.21
- 84182 describes an immunoblot assay. 0584U identifies a qualitative CSF prion test using QUIC.
0584U billing questions
What specimen does 0584U identify?
The test detects prion protein in cerebrospinal fluid. It reports a qualitative result.
How is this different from a total CSF protein test?
0584U detects prion protein using QUIC. A total CSF protein test measures the overall protein concentration in the specimen.
Is 0584U a quantitative test?
No. It reports a qualitative result rather than a measured concentration.
How does Medicare pay 0584U?
Medicare pays it under the CLFS at one national amount per code, without geographic or office-versus-facility adjustment.
Does Medicare pay a separate physician interpretation for 0584U?
0584U is paid through the CLFS only and has no physician fee schedule payment.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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