CPT code 0660U: HPV cfDNA, genotypes 18, 31, 33, 352026 Medicare lab fee · Clinical Laboratory Fee Schedule
This quantitative whole-blood assay detects cell-free DNA from HPV genotypes 18, 31, 33, and 35 for reporting the specified molecular test.
Medicare has no national amount for 0660U: it’s on the 2026 Clinical Laboratory Fee Schedule as contractor-priced, so each Medicare Administrative Contractor sets the payment.
Medicare lab fee · CLFS 2026 Q4
Contractor-priced (CLFS indicator L)
Set by your MAC
CMS lists 0660U on the Clinical Laboratory Fee Schedule without a national amount: each Medicare Administrative Contractor prices it for its jurisdiction.
- National amount
- None
- Priced by
- Each MAC
- Fee schedule
- Clinical lab
- CMS updates
- Quarterly
The contractor that processes the claim sets the amount for its jurisdiction. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 7 sections
What 0660U covers
This quantitative multiplex digital droplet PCR assay analyzes whole-blood cell-free DNA for HPV genotypes 18, 31, 33, and 35. It measures the specified genotype targets in circulating DNA and is distinct from conventional high-risk HPV nucleic acid testing used for cervical screening. A clinical laboratory performs the analysis and reports results to the ordering clinician. The result concerns circulating HPV cfDNA, not a general HPV infection screen.
Report 0660U when this four-genotype whole-blood cfDNA assay is performed. Medicare pays the code under the Clinical Laboratory Fee Schedule (CLFS) only. It was added to the CLFS effective October 1, 2026, and is locally priced, with each Medicare Administrative Contractor setting the payment. The code has no physician fee schedule payment.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 0660U
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
Priced by each contractor
0660U carries CLFS indicator L: CMS publishes no national amount, and each Medicare Administrative Contractor sets the payment for its jurisdiction. Ask your MAC for its current amount.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Not on the physician fee schedule
The physician fee schedule doesn’t list 0660U: Medicare pays the test only from the CLFS.
0660U compared with similar tests
- 0661UHPV 16 cfDNAWhole blood, quantitative ddPCRNo national amount
- 0661U targets HPV genotype 16 in cell-free DNA. 0660U targets genotypes 18, 31, 33, and 35.
- 87624High-risk HPVPooled result$35.09
- 87624 reports high-risk HPV nucleic acid detection, rather than quantitative whole-blood cfDNA testing for the four genotypes covered by 0660U.
- 87625HPV genotypingTypes 16 and 18$40.55
- 87625 targets HPV genotypes 16 and 18. 0660U measures cfDNA for genotypes 18, 31, 33, and 35.
0660U billing questions
When should 0660U be chosen over 0661U?
0660U is for the whole-blood cfDNA assay targeting HPV genotypes 18, 31, 33, and 35. 0661U targets HPV genotype 16 in cfDNA.
What specimen does 0660U describe?
It describes analysis of whole-blood cell-free DNA.
How does 0660U differ from conventional high-risk HPV testing?
0660U measures cfDNA for four specified HPV genotypes in whole blood. Conventional high-risk HPV nucleic acid testing is a different test.
Is physician interpretation separately payable?
Medicare pays 0660U through the CLFS only; the code has no physician fee schedule payment.
How does Medicare set payment for 0660U?
The code is locally priced under the CLFS, with each Medicare Administrative Contractor setting the payment.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
Fee sheets · Coming soon
Put 0660U and the rest of your codes on one sheet
Your codes at your locality, with payer contracts beside Medicare.
Join the waitlist