CPT code 0669U: Blood pathogen panel, three genera, digital PCR2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Multiplex digital PCR tests blood for Bartonella, Borrelia, and Babesia DNA, reporting presence or absence at the genus level for each.
Medicare has no national amount for 0669U: it’s on the 2026 Clinical Laboratory Fee Schedule as contractor-priced, so each Medicare Administrative Contractor sets the payment.
Medicare lab fee · CLFS 2026 Q4
Contractor-priced (CLFS indicator L)
Set by your MAC
CMS lists 0669U on the Clinical Laboratory Fee Schedule without a national amount: each Medicare Administrative Contractor prices it for its jurisdiction.
- National amount
- None
- Priced by
- Each MAC
- Fee schedule
- Clinical lab
- CMS updates
- Quarterly
The contractor that processes the claim sets the amount for its jurisdiction. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 7 sections
What 0669U covers
0669U is a proprietary laboratory analysis using multiplex digital PCR on blood to detect DNA from Bartonella, Borrelia, and Babesia. It produces a separate qualitative presence-or-absence result at the genus level for each target; it does not report which species within a genus is present. The code represents the combined three-genus assay, rather than a result for only one of these organism groups.
Report 0669U for the combined assay and its three genus-level results. The code was added to the CLFS effective October 1, 2026, and is paid through the CLFS. It is locally priced, so each Medicare Administrative Contractor sets the payment. There is no separate physician fee schedule payment for this code.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 0669U
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
Priced by each contractor
0669U carries CLFS indicator L: CMS publishes no national amount, and each Medicare Administrative Contractor sets the payment for its jurisdiction. Ask your MAC for its current amount.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Not on the physician fee schedule
The physician fee schedule doesn’t list 0669U: Medicare pays the test only from the CLFS.
0669U compared with similar tests
- 87476Lyme DNA testAmplified probe$35.09
- This code targets Borrelia alone. Choose 0669U when the combined Bartonella, Borrelia, and Babesia blood assay is performed and reported.
- 86618Lyme antibodyLyme disease antibody$17.03
- 86618 is an antibody test for Lyme disease; 0669U detects pathogen DNA and also includes Bartonella and Babesia.
- 0666UWound PCR panelWound-swab real-time PCRNo national amount
- 0666U is an infectious-disease multiplex DNA assay associated with wound testing. 0669U tests blood for Bartonella, Borrelia, and Babesia.
0669U billing questions
What does 0669U report?
It reports whether DNA from Bartonella, Borrelia, and Babesia is detected in blood, with a separate qualitative result for each genus.
Does this test identify the species?
No. The result is reported at the genus level and indicates presence or absence, rather than naming a species.
How does 0669U differ from a Borrelia-only test?
0669U tests for three genera in one blood assay. A Borrelia-specific molecular test, such as 87476, may be an alternative when testing only for Borrelia is appropriate.
How does Medicare pay 0669U?
Medicare pays it under the CLFS. It is locally priced, with each Medicare Administrative Contractor setting the payment, and has no separate physician fee schedule payment.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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