CPT code 65780: Amniotic membrane graft, multiple layers2026 Medicare rate & RVUs in Maine
Ophthalmologists use this surgery to rebuild a damaged ocular surface with multiple layers of amniotic membrane, such as for a persistent epithelial defect.
CMS doesn’t publish an office rate for 65780 in Maine.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
Your location
On this page 9 sections
What 65780 covers
An ophthalmologist, often a cornea specialist, places multiple layers of amniotic membrane on the ocular surface to support reconstruction and healing. This approach may be used for severe surface damage, including a persistent epithelial defect or injury from a chemical or thermal burn. The service is typically performed in an operating room or other surgical setting when the extent of the ocular surface problem calls for multilayer reconstruction.
Report this code when the operative record supports amniotic membrane reconstruction using multiple layers. The documentation should identify the treated eye, the ocular surface condition, and the multilayer technique; do not report separate units for each layer. Medicare assigns a 90-day global period, which includes the day-before preoperative visit and related postoperative care during that period. When multiple procedures are performed in the same session, the highest-valued procedure is paid in full and other procedures are subject to the standard 50% reduction. Modifier 50 applies to bilateral procedures, paid at 150%. Assistant-at-surgery payment is restricted; co-surgeons require supporting documentation, and team surgery is not permitted.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where 65780 pays more and less in Maine
| Payment locality | Office | Facility |
|---|---|---|
| Rest of Maine | Unavailable | $487.69 |
| Southern Maine, ME | Unavailable | $506.97 |
How the 65780 rate is calculated
Each of 65780’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 65780
RVUs × geographic indexes × conversion factor
Work6.85
6.85 RVUs× 1.000 GPCI
Practice expense8.06
8.06 RVUs× 1.000 GPCI
Malpractice0.54
0.54 RVUs× 1.000 GPCI
Adjusted RVUs
15.4500
Conversion factor
$33.4009
Medicare rate
$516.04
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for 65780
65780 has a 90-day global period: related visits in that window are included in the surgery payment.
CMS payment indicators · 65780
Amniotic membrane graft, multiple layers
| Rule | CMS value | What it means |
|---|---|---|
| Global period | 090 | Major surgery: the day before, the day of, and 90 days after are included. |
| Multiple procedures | 2 | Standard reduction: highest-valued procedure at 100%, others at 50%. |
| Bilateral (modifier 50) | 1 | Bilateral with modifier 50 pays 150% of the fee schedule amount. |
| Assistant at surgery (80/81/82/AS) | 1 | Not paid (statutory restriction). |
| Co-surgeons (62) | 1 | Permitted with supporting documentation. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 0 | Physician service: no professional/technical split. |
| Split (54/55/56) | 0.10/0.70/0.20 | Share of the payment for pre-op, the procedure itself, and post-op care. |
Global surgery period · 65780
Amniotic membrane graft, multiple layers
90-day global period ends
Dec 30, 2026
Covers Sep 30, 2026 through Dec 30, 2026 (92 days, including the day before surgery).
Visit on Oct 31, 2026
Day 30 of the 90-day post-op period: related follow-up care is included in the surgical payment.
Pre-op dayGlobal period
What modifiers do to the payment
Modifier 50 · payment effect
With and without the modifier
65780 without 50 · national facility
$516.04
Amniotic membrane graft, multiple layers
65780-50 · Bilateral: 150%
$774.06
Both sides on one line with modifier 50 are paid at 150% of the fee schedule amount (subject to multiple-procedure rules with other procedures).
65780 compared with similar codes
Compare codes · National
5 codes, side by side
How to choose
- 65778Amniotic membraneWithout sutures
- Use 65778 for single-layer amniotic membrane treatment with a self-retaining technique; use 65780 when multiple layers are placed.
- 65779Amniotic membraneSingle layer, sutured
- Use 65779 for a single sutured layer. The multilayer reconstruction described by 65780 is a different service.
- 65781Ocular reconstructionLimbal stem cell allograft
- 65781 involves limbal stem cell allograft reconstruction, rather than multilayer amniotic membrane placement.
- 65782Ocular reconstructionAutologous limbal stem cell graft
- 65782 uses the patient's own limbal stem cells for reconstruction; 65780 represents multilayer amniotic membrane reconstruction.
65780 billing questions
How do I distinguish this from 65778 or 65779?
This code is for multilayer amniotic membrane reconstruction. Codes 65778 and 65779 describe single-layer techniques, distinguished by whether the membrane is self-retaining or sutured.
Can I report multiple units for multiple membrane layers?
No. The multiple-layer technique is represented by this code; do not count each layer as a separate unit.
What documentation supports the code?
Document the ocular surface condition, the treated eye, and that the reconstruction used multiple layers of amniotic membrane.
How does the 90-day global period affect postoperative billing?
The day-before preoperative visit and related postoperative care for 90 days are included in the global period.
Can this be billed bilaterally?
For bilateral performance, CMS pays the procedure with modifier 50 at 150%.
Can an assistant surgeon or co-surgeon be reported?
Assistant-at-surgery payment is subject to a statutory restriction. Co-surgeons are paid only with supporting documentation; team surgery is not permitted.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
Fee sheets · Coming soon
Put 65780 and the rest of your codes on one sheet
Your codes at your locality, with payer contracts beside Medicare.
Join the waitlist