CPT code 68100: Conjunctival biopsy, diagnostic tissue sampling2026 Medicare rate & RVUs in Baltimore area, MD

Reports sampling of conjunctival tissue for pathologic evaluation, commonly when an ocular surface abnormality requires diagnosis rather than complete removal.

CMS RVU26DEffective Oct 1, 2026One payment locality1.3K Medicare services in 2024

In Baltimore area, MD, Medicare pays $190.90 for 68100 in the office and $85.18 when it’s performed in a hospital or facility.

$190.90Office (non-facility)
$85.18Hospital or facility
+6.2%vs the national office rate ($179.70)

Check a contract rate as a % of Medicare · 68100 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 68100 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Baltimore area, MD
  2. What 68100 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 68100 covers

Code 68100 represents removal of a conjunctival tissue sample for diagnostic examination rather than treatment by complete lesion removal. Ophthalmologists commonly use it for a suspicious conjunctival growth, pigmented area, or persistent abnormal tissue when histology is needed. The biopsy may be performed in an office or facility, and the specimen is submitted for pathologic evaluation.

Choose this service when tissue is sampled to establish a diagnosis; do not select an excision code solely because the sampled area has a particular size. The procedure note should identify the eye and conjunctival site, the tissue sampled, and the diagnostic purpose; document both eyes when bilateral. CMS assigns a 0-day global period, so same-day preoperative and postoperative care is included. In a session with multiple procedures, the highest-valued procedure is paid in full and the others at 50%. Bilateral reporting with modifier 50 is paid at 150%. Medicare does not pay assistant-at-surgery services; co-surgeons and team surgery are not permitted.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Baltimore area, MD compares for 68100

Across 109 of 109 payment localities, the office rate for 68100 runs from $159.31 in Arkansas to $241.16 in San Benito County, CA. Baltimore area, MD pays $190.90. The RVUs are the same everywhere; the geographic indexes change the dollars.

68100 in Baltimore area, MD vs other payment areas
  1. Baltimore area, MD · this page$190.90
  2. Rest of Maryland · Maryland$181.42−$9.48
  3. Los Angeles, CA · California$204.41+$13.51
  4. Washington, DC area · District of Columbia$205.98+$15.08
  5. Miami, FL · Florida$190.72−$0.18
  6. Chicago, IL · Illinois$185.42−$5.48
  7. Manhattan, NY · New York$206.04+$15.14

Other areas in Maryland first, then benchmark localities. Bars start at $0.

Every other payment area

68100 in every other Medicare payment locality
Payment localityOfficeFacility
AlaskaAlaska$208.67$103.73
AlabamaAlabama$161.61$75.39
ArkansasArkansas$159.31$74.67
ArizonaArizona$175.08$79.60
Bakersfield, CACalifornia$191.76$83.77
Chico, CACalifornia$191.41$83.42
El Centro, CACalifornia$191.43$83.43
Fresno, CACalifornia$191.41$83.42

68100 rates by state

Office rate range in each state. Select a state to see its payment localities.

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$159.31

$216.29

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
68100 office rate range by state
State / territoryOffice rate rangeLocalities
AK$208.671
AL$161.611
AR$159.311
AZ$175.081
CA$191.41–$241.1629
CO$187.871
CT$191.511
DC$205.981
DE$177.961
FL$175.74–$190.723
GA$166.15–$182.682
GU$196.221
HI$196.221
IA$166.271
ID$167.211
IL$170.29–$186.404
IN$168.181
KS$165.211
KY$164.741
LA$164.37–$172.412
MA$186.65–$206.702
MD$181.42–$205.983
ME$167.75–$177.152
MI$168.69–$177.602
MN$180.941
MO$161.39–$173.373
MS$160.401
MT$179.691
NC$169.531
ND$177.511
NE$167.251
NH$184.651
NJ$193.95–$203.832
NM$169.481
NV$179.221
NY$172.01–$210.605
OH$168.251
OK$164.761
OR$178.08–$194.112
PA$168.68–$186.612
PR$181.091
RI$184.491
SC$169.121
SD$177.261
TN$165.991
TX$167.56–$187.028
UT$171.411
VA$176.37–$205.982
VI$181.091
VT$176.561
WA$186.38–$211.182
WI$171.611
WV$164.001
WY$178.741

See 68100 in every payment locality

How the 68100 rate is calculated

Each of 68100’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 68100

RVUs × geographic indexes × conversion factor

Office or facility?

Work1.32

1.32 RVUs× 1.000 GPCI

Practice expense3.95

3.95 RVUs× 1.000 GPCI

Malpractice0.11

0.11 RVUs× 1.000 GPCI

Adjusted RVUs

5.3800

Conversion factor

$33.4009

Medicare rate

$179.70

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Baltimore area, MD inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

7,535

Code
68100
Physician work
1.32
Practice expense
3.95
Malpractice
0.11

GPCI2026.csv

60

Locality
Baltimore area, MD
Physician work
1.016
Practice expense
1.073
Malpractice
1.237
Office calculation for 68100 in Baltimore area, MD
ComponentRVULocality factorAdjusted
Physician work1.32× 1.0161.3411
Practice expense3.95× 1.0734.2383
Malpractice0.11× 1.2370.1361
Total RVUs5.7155
Conversion factor× 33.4009

Office rate, Baltimore area, MD$190.90

Office: (1.32 × 1.016 + 3.95 × 1.073 + 0.11 × 1.237) × $33.4009 = $190.90

Facility: (1.32 × 1.016 + 1 × 1.073 + 0.11 × 1.237) × $33.4009 = $85.18

Open 68100 in the RVU calculator

Payment rules and modifiers for 68100

The CMS indicators that decide how 68100 is paid alongside other services.

CMS payment indicators · 68100

Conjunctival biopsy, diagnostic tissue sampling

RuleCMS valueWhat it means
Global period000Same-day global: pre- and post-op care on the day of the procedure is included.
Multiple procedures2Standard reduction: highest-valued procedure at 100%, others at 50%.
Bilateral (modifier 50)1Bilateral with modifier 50 pays 150% of the fee schedule amount.
Assistant at surgery (80/81/82/AS)1Not paid (statutory restriction).
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.

What modifiers do to the payment

Modifier 50 · payment effect

With and without the modifier

68100 without 50 · national office

$179.70

Conjunctival biopsy, diagnostic tissue sampling

68100-50 · Bilateral: 150%

$269.55

Both sides on one line with modifier 50 are paid at 150% of the fee schedule amount (subject to multiple-procedure rules with other procedures).

When to use modifier 50

How 68100 has changed in Baltimore area, MD

68100 · Office / nonfacility

$190.90

Effective 2026-10-01

The base rate is $8.77 higher than on 2025-10-01, moving from $182.13 to $190.90 (4.8%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release
  1. January 1, 2026

    RVU26A

    $182.13changed to$190.90

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 1.35 changed to 1.32
    • Practice expense RVU 3.80 changed to 3.95
    • Malpractice RVU 0.12 changed to 0.11
    • Work GPCI 1.020 changed to 1.016
    • Practice expense GPCI 1.078 changed to 1.073
    • Malpractice GPCI 1.309 changed to 1.237

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $190.94changed to$182.13

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 3.91 changed to 3.80
    • Malpractice RVU 0.11 changed to 0.12

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $187.82changed to$190.94

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $196.13changed to$187.82

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 3.92 changed to 3.91
    • Work GPCI 1.024 changed to 1.020
    • Practice expense GPCI 1.087 changed to 1.078
    • Malpractice GPCI 1.311 changed to 1.309
  5. January 1, 2023

    RVU23A

    $201.70changed to$196.13

    • Conversion factor 34.6062 changed to 33.8872
    • Work GPCI 1.028 changed to 1.024
    • Practice expense GPCI 1.096 changed to 1.087
    • Malpractice GPCI 1.313 changed to 1.311

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $203.38changed to$201.70

    • Conversion factor 34.8931 changed to 34.6062

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $197.43changed to$203.38

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 3.60 changed to 3.92
    • Work GPCI 1.026 changed to 1.028
    • Practice expense GPCI 1.095 changed to 1.096
    • Malpractice GPCI 1.304 changed to 1.313

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $193.35changed to$197.43

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 3.52 changed to 3.60
    • Malpractice RVU 0.10 changed to 0.11
    • Work GPCI 1.023 changed to 1.026
    • Malpractice GPCI 1.295 changed to 1.304

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $189.59changed to$193.35

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 3.43 changed to 3.52

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $185.38changed to$189.59

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 3.34 changed to 3.43
    • Practice expense GPCI 1.096 changed to 1.095
    • Malpractice GPCI 1.238 changed to 1.295

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $184.86changed to$185.38

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense GPCI 1.097 changed to 1.096
    • Malpractice GPCI 1.181 changed to 1.238

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $185.14changed to$184.86

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 3.33 changed to 3.34

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $184.21changed to$185.14

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $187.77changed to$184.21

    • Conversion factor 35.8228 changed to 35.7547
    • Practice expense RVU 3.31 changed to 3.33
    • Malpractice RVU 0.19 changed to 0.10
    • Work GPCI 1.025 changed to 1.023
    • Malpractice GPCI 1.194 changed to 1.181

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $191.98changed to$187.77

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 3.66 changed to 3.31
    • Malpractice RVU 0.20 changed to 0.19
    • Work GPCI 1.027 changed to 1.025
    • Malpractice GPCI 1.206 changed to 1.194

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: $191.98

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$190.90$85.18RVU26D
2026-07-01$190.90$85.18RVU26C
2026-04-01$190.90$85.18RVU26B
2026-01-01$190.90$85.18RVU26A
2025-10-01$182.13$98.09RVU25D
2025-07-01$182.13$98.09RVU25C
2025-04-01$182.13$98.09RVU25B
2025-01-01$182.13$98.09RVU25A
2024-10-01$190.94$99.79RVU24D
2024-07-01$190.94$99.79RVU24C
2024-04-01$190.94$99.79RVU24B
2024-03-09$190.94$99.79RVU24AR
2024-01-01$187.82$98.16RVU24A
2023-10-01$196.13$101.09RVU23D
2023-07-01$196.13$101.09RVU23C
2023-04-01$196.13$101.09RVU23B
2023-01-01$196.13$101.09RVU23A
2022-10-01$201.70$101.95RVU22D
2022-07-01$201.70$101.95RVU22C
2022-04-01$201.70$101.95RVU22B
2022-01-01$201.70$101.95RVU22A
2021-10-01$203.38$102.80RVU21D
2021-07-01$203.38$102.80RVU21C
2021-04-01$203.38$102.80RVU21B
2021-01-01$203.38$102.80RVU21A
2020-10-01$197.43$104.96RVU20D
2020-07-01$197.43$104.96RVU20C
2020-04-01$197.43$104.96RVU20B
2020-01-01$197.43$104.96RVU20A
2019-10-01$193.35$105.74RVU19D
2019-07-01$193.35$105.74RVU19C
2019-04-01$193.35$105.74RVU19B
2019-01-01$193.35$105.74RVU19A
2018-10-01$189.59$106.81RVU18D
2018-07-01$189.59$106.81RVU18C
2018-04-01$189.59$106.81RVU18B
2018-01-01$189.59$106.81RVU18AR1
2017-10-01$185.38$105.93RVU17D
2017-07-01$185.38$105.93RVU17C
2017-04-01$185.38$105.93RVU17B
2017-01-01$185.38$105.93RVU17A
2016-10-01$184.86$105.13RVU16D
2016-07-01$184.86$105.13RVU16C
2016-04-01$184.86$105.13RVU16B
2016-01-01$184.86$105.13RVU16A
2015-10-01$185.14$105.51RVU15D
2015-07-01$185.14$105.51RVU15C
2015-04-01$184.21$104.98RVU15B
2015-01-01$184.21$104.98RVU15A
2014-10-01$187.77$109.18RVU14D
2014-07-01$187.77$109.18RVU14C
2014-04-01$187.77$109.18RVU14B
2014-01-01$187.77$109.18RVU14A
2013-10-01$191.98$109.50RVU13D
2013-07-01$191.98$109.50RVU13C
2013-04-01$191.98$109.50RVU13B
2013-01-01$191.98$109.50RVU13AR

Price 68100 for an earlier date of service

Where the Baltimore area, MD rate applies

Baltimore area, MD is a Medicare payment area, not a city. Our Census mapping connects it to 100 cities and communities in Maryland. Some span more than one payment area; confirm with the service ZIP.

  • Baltimore
  • Aberdeen
  • Aberdeen Proving Ground
  • Abingdon
  • Annapolis
  • Annapolis Neck
  • Arbutus
  • Arden on the Severn

Browse all communities in Maryland

68100 billing questions

How does 68100 differ from 68110?

68100 represents sampling tissue to establish a diagnosis. 68110 represents excision of a conjunctival lesion smaller than 1 cm, when the service is lesion removal rather than a diagnostic sample.

Can the pathology examination be billed separately?

68100 represents obtaining the conjunctival specimen. The pathologist’s examination is a separate service and may be reported under the applicable surgical pathology code when performed.

How is a biopsy performed on both eyes reported?

Report modifier 50 when the service is bilateral and document the biopsy on each eye. CMS pays the bilateral procedure at 150%.

Is same-day preoperative or postoperative care included?

Yes. The 0-day global period includes same-day preoperative and postoperative care for the biopsy.

What happens when 68100 is performed with other procedures?

For procedures performed in the same session, CMS pays the highest-valued procedure in full and the other procedures at 50%. Assistant-at-surgery payment is restricted, and co-surgeons and team surgery are not permitted.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 68100PPRRVU2026_Oct_nonQPP.csv, line 7,535 (RVU26D)
Geographic factors for Baltimore area, MDGPCI2026.csv, line 60 (RVU26D)

Open CMS sourceHow we calculate rates

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