CPT code 78111: Plasma volume, multiple sampling2026 Medicare rate & RVUs in Texas
Nuclear medicine measurement of circulating plasma volume using multiple blood samples, reported when serial sampling is used to assess a suspected blood-volume abnormality.
Medicare pays $88.81–$101.80 for 78111 in the office in Texas, from Beaumont, TX to Austin, TX. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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On this page 9 sections
What 78111 covers
This study measures circulating plasma volume through tracer administration followed by collection and analysis of multiple blood samples. It may be used when a clinician needs to assess plasma-volume expansion or depletion, including in the evaluation of an apparent red-cell concentration abnormality. Nuclear medicine staff typically perform the technical work in a hospital setting, while a qualified physician interprets the study and reports the findings.
Choose this code when the plasma-volume study uses multiple samples; the single-sampling service is a different code. Documentation should identify the clinical reason for the study, the sampling approach, and the interpretation. Medicare recognizes separate professional and technical components: report modifier 26 for the interpretation, modifier TC for the equipment and staff, or neither modifier for the global service. Medicare’s 2024 claims data show facility services for this code and no office services.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where 78111 pays more and less in Texas
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
8 payment localities
$88.81 to $101.80
8 of 8 payment localities
| Payment locality | Office | Facility |
|---|---|---|
| Austin, TX | $101.80 | Unavailable |
| Beaumont, TX | $88.81 | Unavailable |
| Brazoria, TX | $95.76 | Unavailable |
| Dallas, TX | $96.34 | Unavailable |
| Fort Worth, TX | $95.48 | Unavailable |
| Galveston, TX | $96.01 | Unavailable |
| Houston, TX | $96.93 | Unavailable |
| Rest of Texas | $92.20 | Unavailable |
How the 78111 rate is calculated
Each of 78111’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 78111
RVUs × geographic indexes × conversion factor
Work0.21
0.21 RVUs× 1.000 GPCI
Practice expense2.64
2.64 RVUs× 1.000 GPCI
Malpractice0.05
0.05 RVUs× 1.000 GPCI
Adjusted RVUs
2.9000
Conversion factor
$33.4009
Medicare rate
$96.86
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for 78111
The CMS indicators that decide how 78111 is paid alongside other services.
CMS payment indicators · 78111
Plasma volume, multiple sampling
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
78111 without 26 · national office
$96.86
Plasma volume, multiple sampling
78111-26 · Professional component
$10.35
Pays only the interpretation and report.
78111 compared with similar codes
Compare codes · National
4 codes, side by side
How to choose
- 78110Plasma volumeSingle sample
- 78110 is the plasma-volume study when a single sample is used. Choose 78111 for a multiple-sample approach.
- 78121Red cell massMultiple determinations
- 78121 measures red-cell mass using multiple sampling; 78111 measures plasma volume. The measured blood component determines the code.
- 78122Blood volume testWhole blood determination
- 78122 is for determining whole blood volume. Use 78111 when the measured quantity is plasma volume alone.
78111 billing questions
How does this differ from the single-sampling plasma-volume code?
Report 78111 when the study uses multiple blood samples. Use 78110 when the plasma-volume determination uses a single sample.
Which modifier identifies the physician interpretation?
Use modifier 26 for the professional component, which represents interpretation. Modifier TC identifies the technical component.
Can the technical and professional components be billed separately?
Yes. The physician or other billing entity may report the applicable component with modifier 26 or TC; billing without either modifier represents the global service.
What documentation supports reporting the multiple-sample service?
The record should support the clinical reason for measuring plasma volume, document that multiple samples were used, and include the interpretation when the professional component is billed.
How does this differ from a whole blood volume determination?
78111 measures plasma volume using multiple samples. 78122 is used when the requested study determines whole blood volume rather than plasma volume alone.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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