CPT code 78121: Red cell mass, multiple determinations2026 Medicare rate & RVUs in Merced, CA

Reports a nuclear medicine study that determines circulating red cell mass using multiple measurements, often during evaluation of erythrocytosis.

CMS RVU26DEffective Oct 1, 2026One payment locality219 Medicare services in 2024

In Merced, CA, Medicare pays $105.14 for 78121 in the office.

$105.14Office (non-facility)
Not available in this settingHospital or facility
+7.8%vs the national office rate ($97.53)

Check a contract rate as a % of Medicare · 78121 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 78121 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Merced, CA
  2. What 78121 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 78121 covers

This study measures the amount of red blood cells circulating in the patient’s body. It commonly involves labeling the patient’s red cells, returning them to circulation, and obtaining multiple measurements from blood samples. Nuclear medicine staff perform the technical work, and a qualified physician interprets the results. The test may help evaluate whether an elevated red cell count reflects increased red cell mass or another cause, such as reduced plasma volume.

Select this code when the performed study includes multiple red cell mass determinations; use the single-determination code when only one is performed. Documentation should identify the study performed, its multiple measurements, and the physician’s interpretation. CMS recognizes professional and technical components: modifier 26 identifies interpretation, modifier TC identifies equipment and staff, and billing without either modifier represents the global service. Modifiers 26 and TC are separately priced.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Merced, CA compares for 78121

Across 109 of 109 payment localities, the office rate for 78121 runs from $84.66 in Arkansas to $135.69 in San Benito County, CA. Merced, CA pays $105.14. The RVUs are the same everywhere; the geographic indexes change the dollars.

78121 in Merced, CA vs other payment areas
  1. Merced, CA · this page$105.14
  2. Bakersfield, CA · California$105.28+$0.14
  3. Chico, CA · California$105.14
  4. El Centro, CA · California$105.15+$0.01
  5. Fresno, CA · California$105.14
  6. Hanford, CA · California$105.14
  7. Los Angeles, CA · California$113.04+$7.90

Other areas in California first, then benchmark localities. Bars start at $0.

Every other payment area

78121 in every other Medicare payment locality
Payment localityOfficeFacility
Madera, CACalifornia$105.14—
Modesto, CACalifornia$105.14—
Napa, CACalifornia$124.55—
Oxnard, CACalifornia$112.75—
Redding, CACalifornia$105.14—
Rest of CaliforniaCalifornia$105.14—
Riverside, CACalifornia$105.68—
Sacramento, CACalifornia$111.07—

78121 rates by state

Office rate range in each state. Select a state to see its payment localities.

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$84.66

$120.41

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
78121 office rate range by state
State / territoryOffice rate rangeLocalities
AK$107.521
AL$86.121
AR$84.661
AZ$94.641
CA$105.14–$135.6929
CO$102.761
CT$104.671
DC$113.501
DE$96.391
FL$94.61–$103.593
GA$88.62–$99.272
GU$108.541
HI$108.541
IA$89.261
ID$89.811
IL$91.03–$101.204
IN$90.431
KS$88.491
KY$87.901
LA$87.63–$92.712
MA$101.89–$114.362
MD$98.52–$113.503
ME$90.06–$96.142
MI$90.31–$95.682
MN$98.831
MO$85.69–$93.433
MS$85.211
MT$97.531
NC$91.201
ND$96.541
NE$89.911
NH$100.831
NJ$105.97–$111.982
NM$90.771
NV$97.341
NY$92.76–$115.795
OH$90.101
OK$88.011
OR$96.69–$106.762
PA$90.43–$101.552
PR$98.451
RI$100.371
SC$90.781
SD$96.421
TN$88.981
TX$89.72–$102.328
UT$92.231
VA$95.59–$113.502
VI$98.451
VT$95.851
WA$101.80–$117.152
WI$92.781
WV$87.051
WY$97.101

See 78121 in every payment locality

How the 78121 rate is calculated

Each of 78121’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 78121

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.31

0.31 RVUs× 1.000 GPCI

Practice expense2.56

2.56 RVUs× 1.000 GPCI

Malpractice0.05

0.05 RVUs× 1.000 GPCI

Adjusted RVUs

2.9200

Conversion factor

$33.4009

Medicare rate

$97.53

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Merced, CA inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

9,233

Code
78121
Physician work
0.31
Practice expense
2.56
Malpractice
0.05

GPCI2026.csv

15

Locality
Merced, CA
Physician work
1.017
Practice expense
1.096
Malpractice
0.536
Office calculation for 78121 in Merced, CA
ComponentRVULocality factorAdjusted
Physician work0.31× 1.0170.3153
Practice expense2.56× 1.0962.8058
Malpractice0.05× 0.5360.0268
Total RVUs3.1478
Conversion factor× 33.4009

Office rate, Merced, CA$105.14

Office: (0.31 × 1.017 + 2.56 × 1.096 + 0.05 × 0.536) × $33.4009 = $105.14

Open 78121 in the RVU calculator

Payment rules and modifiers for 78121

The CMS indicators that decide how 78121 is paid alongside other services.

CMS payment indicators · 78121

Red cell mass, multiple determinations

RuleCMS valueWhat it means
Global periodXXXThe global surgery concept doesn’t apply.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical1Diagnostic test with separate professional (26) and technical (TC) components.

What modifiers do to the payment

Modifier 26 · payment effect

With and without the modifier

78121 without 26 · national office

$97.53

Red cell mass, multiple determinations

78121-26 · Professional component

$14.70

Pays only the interpretation and report.

When to use modifier 26

How 78121 has changed in Merced, CA

78121 · Office / nonfacility

$105.14

Effective 2026-10-01

The base rate is $6.77 higher than on 2025-10-01, moving from $98.37 to $105.14 (6.9%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release
  1. January 1, 2026

    RVU26A

    $98.37changed to$105.14

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 0.32 changed to 0.31
    • Practice expense RVU 2.46 changed to 2.56
    • Work GPCI 1.014 changed to 1.017
    • Practice expense GPCI 1.093 changed to 1.096
    • Malpractice GPCI 0.560 changed to 0.536

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $82.32changed to$98.37

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 1.94 changed to 2.46

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $80.97changed to$82.32

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $82.62changed to$80.97

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 1.93 changed to 1.94
    • Work GPCI 1.021 changed to 1.014
    • Practice expense GPCI 1.079 changed to 1.093
    • Malpractice GPCI 0.579 changed to 0.560
  5. January 1, 2023

    RVU23A

    $84.27changed to$82.62

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 1.95 changed to 1.93
    • Work GPCI 1.027 changed to 1.021
    • Practice expense GPCI 1.065 changed to 1.079
    • Malpractice GPCI 0.597 changed to 0.579

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $84.60changed to$84.27

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 1.94 changed to 1.95

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $84.87changed to$84.60

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 1.87 changed to 1.94
    • Malpractice RVU 0.04 changed to 0.05
    • Work GPCI 1.024 changed to 1.027
    • Practice expense GPCI 1.070 changed to 1.065
    • Malpractice GPCI 0.580 changed to 0.597

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $84.95changed to$84.87

    • Conversion factor 36.0391 changed to 36.0896
    • Work GPCI 1.020 changed to 1.024
    • Practice expense GPCI 1.074 changed to 1.070
    • Malpractice GPCI 0.562 changed to 0.580

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $94.53changed to$84.95

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 2.12 changed to 1.87

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $116.42changed to$94.53

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 2.68 changed to 2.12
    • Work GPCI 1.024 changed to 1.020
    • Practice expense GPCI 1.079 changed to 1.074
    • Malpractice GPCI 0.610 changed to 0.562

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    No ratechanged to$116.42

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2013

    RVU13AR

    Earliest loaded release: No rate

    Held through RVU13B, RVU13C, RVU13D, RVU14A, RVU14B, RVU14C, RVU14D, RVU15A, RVU15B, RVU15C, RVU15D, RVU16A, RVU16B, RVU16C, RVU16D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$105.14Not available in this settingRVU26D
2026-07-01$105.14Not available in this settingRVU26C
2026-04-01$105.14Not available in this settingRVU26B
2026-01-01$105.14Not available in this settingRVU26A
2025-10-01$98.37Not available in this settingRVU25D
2025-07-01$98.37Not available in this settingRVU25C
2025-04-01$98.37Not available in this settingRVU25B
2025-01-01$98.37Not available in this settingRVU25A
2024-10-01$82.32Not available in this settingRVU24D
2024-07-01$82.32Not available in this settingRVU24C
2024-04-01$82.32Not available in this settingRVU24B
2024-03-09$82.32Not available in this settingRVU24AR
2024-01-01$80.97Not available in this settingRVU24A
2023-10-01$82.62Not available in this settingRVU23D
2023-07-01$82.62Not available in this settingRVU23C
2023-04-01$82.62Not available in this settingRVU23B
2023-01-01$82.62Not available in this settingRVU23A
2022-10-01$84.27Not available in this settingRVU22D
2022-07-01$84.27Not available in this settingRVU22C
2022-04-01$84.27Not available in this settingRVU22B
2022-01-01$84.27Not available in this settingRVU22A
2021-10-01$84.60Not available in this settingRVU21D
2021-07-01$84.60Not available in this settingRVU21C
2021-04-01$84.60Not available in this settingRVU21B
2021-01-01$84.60Not available in this settingRVU21A
2020-10-01$84.87Not available in this settingRVU20D
2020-07-01$84.87Not available in this settingRVU20C
2020-04-01$84.87Not available in this settingRVU20B
2020-01-01$84.87Not available in this settingRVU20A
2019-10-01$84.95Not available in this settingRVU19D
2019-07-01$84.95Not available in this settingRVU19C
2019-04-01$84.95Not available in this settingRVU19B
2019-01-01$84.95Not available in this settingRVU19A
2018-10-01$94.53Not available in this settingRVU18D
2018-07-01$94.53Not available in this settingRVU18C
2018-04-01$94.53Not available in this settingRVU18B
2018-01-01$94.53Not available in this settingRVU18AR1
2017-10-01$116.42Not available in this settingRVU17D
2017-07-01$116.42Not available in this settingRVU17C
2017-04-01$116.42Not available in this settingRVU17B
2017-01-01$116.42Not available in this settingRVU17A
2016-10-01Rate data unavailableNot available in this settingRVU16D
2016-07-01Rate data unavailableNot available in this settingRVU16C
2016-04-01Rate data unavailableNot available in this settingRVU16B
2016-01-01Rate data unavailableNot available in this settingRVU16A
2015-10-01Rate data unavailableNot available in this settingRVU15D
2015-07-01Rate data unavailableNot available in this settingRVU15C
2015-04-01Rate data unavailableNot available in this settingRVU15B
2015-01-01Rate data unavailableNot available in this settingRVU15A
2014-10-01Rate data unavailableNot available in this settingRVU14D
2014-07-01Rate data unavailableNot available in this settingRVU14C
2014-04-01Rate data unavailableNot available in this settingRVU14B
2014-01-01Rate data unavailableNot available in this settingRVU14A
2013-10-01Rate data unavailableNot available in this settingRVU13D
2013-07-01Rate data unavailableNot available in this settingRVU13C
2013-04-01Rate data unavailableNot available in this settingRVU13B
2013-01-01Rate data unavailableNot available in this settingRVU13AR

Price 78121 for an earlier date of service

Where the Merced, CA rate applies

Merced, CA is a Medicare payment area, not a city. Our Census mapping connects it to 24 cities and communities in California. Some span more than one payment area; confirm with the service ZIP.

  • Merced
  • Atwater
  • Ballico
  • Bear Creek
  • Cressey
  • Delhi
  • Dos Palos
  • Dos Palos Y

Browse all communities in California

78121 billing questions

When should 78121 be chosen instead of 78120?

Use 78121 when the red cell mass study involves multiple determinations. Use 78120 when the study involves a single determination.

Does “multiple” mean the test was repeated on another date?

It refers to multiple determinations in the performed study, not simply a later repeat of the test. The record should support that the study included multiple measurements.

How should the professional and technical portions be billed?

Report modifier 26 for the physician’s interpretation or modifier TC for the technical service. Without either modifier, the claim represents the global service.

Can plasma volume testing be reported with this study?

A plasma volume determination is a separate measurement from red cell mass and may be performed as part of a blood-volume assessment. The record should support each service reported.

What documentation supports 78121?

Document the red cell mass study, the multiple determinations performed, and the physician’s interpretation. The technical record should support the equipment and staff services when the TC portion is billed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 78121PPRRVU2026_Oct_nonQPP.csv, line 9,233 (RVU26D)
Geographic factors for Merced, CAGPCI2026.csv, line 15 (RVU26D)

Open CMS sourceHow we calculate rates

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