CPT code 81420: Fetal aneuploidy, maternal blood, genomic panel2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Reports genomic analysis of cell-free fetal DNA in maternal blood to assess fetal chromosomal aneuploidy, including analysis of chromosomes 13, 18, and 21.
Medicare pays $759.05 for 81420 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$759.05
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 81420 covers
This prenatal genomic test analyzes cell-free fetal DNA circulating in maternal blood for fetal chromosomal aneuploidy, including chromosomes 13, 18, and 21. It may be ordered during pregnancy when an obstetric clinician evaluates fetal aneuploidy; a clinical laboratory performs and reports the genomic analysis. Results address aneuploidy such as trisomy 21.
Report 81420 for the genomic panel. Medicare pays the test through the Clinical Laboratory Fee Schedule (CLFS). The 2026 national CLFS amount is $759.05, unchanged from 2020 through 2026. CMS sets one amount per code nationwide; payment does not vary by locality or office or facility setting. The test is paid only through the CLFS, not the physician fee schedule.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 81420
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 81420. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 81420 with status X (excluded by statute), so the test itself is paid only from the CLFS.
81420 on the lab fee schedule since 2020
81420 · CLFS 2026 Q4 (current)
$759.05
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
81420 compared with similar tests
- 81422Fetal microdeletion testMaternal blood cell-free DNA$759.05
- 81420 assesses aneuploidy with analysis of chromosomes 13, 18, and 21; 81422 is for fetal chromosomal microdeletion analysis.
- 81507Trisomy screeningTrisomies 21, 18, and 13$795.00
- 81507 reports algorithmic analysis of selected DNA regions for fetal aneuploidy. 81420 reports genomic sequence analysis of cell-free fetal DNA.
- 88267Prenatal karyotypeAmniotic fluid or placental tissue$188.57
- 88267 is chromosome analysis using amniotic-fluid cells. 81420 analyzes cell-free fetal DNA in maternal blood.
81420 billing questions
When should 81420 be reported instead of 81422?
Use 81420 for the fetal aneuploidy genomic panel that includes analysis of chromosomes 13, 18, and 21. Code 81422 addresses fetal chromosomal microdeletions.
Which chromosomes are included in 81420?
The panel includes analysis of chromosomes 13, 18, and 21.
How does 81420 differ from 81507?
81420 describes genomic sequence analysis of cell-free fetal DNA. Code 81507 describes algorithmic analysis of selected DNA regions for fetal aneuploidy.
How does Medicare pay 81420?
Medicare pays 81420 through the CLFS at one national amount per code. The amount applies across localities and does not vary between office and facility settings.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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