CPT code 81441: Bone marrow failure panel, sequence analysis, 30 or more genes2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Sequence analysis of at least 30 genes associated with inherited bone marrow failure syndromes, reported when evaluating suspected hereditary marrow failure.
Medicare pays $2,448.56 for 81441 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$2,448.56
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2023
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 81441 covers
This panel sequences at least 30 genes associated with inherited bone marrow failure syndromes, including genes linked to Fanconi anemia, dyskeratosis congenita, Diamond-Blackfan anemia, and Shwachman-Diamond syndrome. It is used in the evaluation of suspected inherited marrow failure. Hematologists, medical geneticists, and other clinicians may order testing; a molecular laboratory performs and reports the analysis.
Report 81441 for the qualifying multi-gene sequence panel, not a single-gene test or whole-genome sequence analysis. Medicare pays the test only through the CLFS. The 2026 national CLFS amount is $2,448.56, unchanged from 2023 through 2026. The same national amount applies in every locality, without an office-versus-facility adjustment. The code is excluded from the physician fee schedule by statute.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 81441
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 81441. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 81441 with status X (excluded by statute), so the test itself is paid only from the CLFS.
81441 on the lab fee schedule since 2023
81441 · CLFS 2026 Q4 (current)
$2,448.56
Unchanged since Jan 1, 2023
16 quarterly CLFS releases on file, first CLFS 2023 Q1. A code missing from a quarter wasn’t on that release.
81441 compared with similar tests
- 81443Inherited conditions panelAt least 15 genes$2,448.56
- Choose 81441 for a sequence panel focused on inherited bone marrow failure syndrome genes. 81443 describes genetic testing for severe inherited conditions with a different scope.
- 81425Genome sequencingConstitutional or heritable disorders$5,031.20
- 81441 is a focused panel of at least 30 genes associated with inherited bone marrow failure syndromes. 81425 describes genome sequence analysis.
- 81426Genome sequencingEach comparator genome$2,709.95
- 81426 describes genome sequence analysis, whereas 81441 is a focused inherited bone marrow failure gene panel.
81441 billing questions
When should 81441 be selected over a single-gene test?
Use 81441 for sequence analysis of a panel of at least 30 genes associated with inherited bone marrow failure syndromes. A test limited to one gene is not this panel service.
How does 81441 differ from 81443?
81441 is focused on inherited bone marrow failure syndrome genes. 81443 describes genetic testing for severe inherited conditions with a different testing scope.
How does 81441 differ from whole-genome sequence analysis?
81441 describes a focused panel of at least 30 genes associated with inherited bone marrow failure syndromes. Codes 81425 and 81426 describe genome sequence analysis.
Is 81441 paid under the physician fee schedule?
No. Medicare pays 81441 through the CLFS; the code is excluded from the physician fee schedule by statute.
Does Medicare payment vary by locality or setting?
No. The CLFS amount is national and does not vary by locality or between office and facility settings.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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