CPT code 81448: Neuropathy panel, hereditary disorders2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Reports genomic sequencing of a multigene panel for suspected hereditary peripheral nervous system disorders, including inherited neuropathies and spastic paraplegia.
Medicare pays $584.90 for 81448 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$584.90
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 7 sections
What 81448 covers
This panel uses genomic sequencing to evaluate genes associated with hereditary disorders of the peripheral nervous system. It includes at least five peripheral-neuropathy-related genes. The clinical question may involve an inherited neuropathy such as Charcot-Marie-Tooth disease or hereditary spastic paraplegia. A molecular laboratory performs the panel analysis for patients being evaluated for these inherited disorders.
Medicare pays 81448 through the Clinical Laboratory Fee Schedule (CLFS), with one national amount per code across all states and localities and no office-versus-facility payment difference. The 2026 national CLFS amount is $584.90, unchanged since 2020. The test is paid only under the CLFS and is excluded from the physician fee schedule.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 81448
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 81448. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 81448 with status X (excluded by statute), so the test itself is paid only from the CLFS.
81448 on the lab fee schedule since 2020
81448 · CLFS 2026 Q4 (current)
$584.90
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
81448 compared with similar tests
- 81440Mitochondrial gene panelAt least 100 nuclear genes$3,324.00
- 81448 is a multigene panel for hereditary peripheral nervous system disorders; 81440 concerns mitochondrial gene analysis.
- 81460Mitochondrial genomeComplete genome with heteroplasmy$1,287.00
- 81460 analyzes the whole mitochondrial genome. Use 81448 for genomic sequencing of a hereditary peripheral neuropathy panel.
- 81439Cardiomyopathy panelAt least five genes$584.90
- 81439 is a hereditary cardiomyopathy gene panel, addressing an inherited heart muscle disorder rather than a peripheral neuropathy.
81448 billing questions
What conditions does 81448 evaluate?
It evaluates genes associated with hereditary peripheral nervous system disorders, including inherited neuropathies such as Charcot-Marie-Tooth disease and hereditary spastic paraplegia.
How many genes are included in the panel?
The panel includes sequencing of at least five peripheral-neuropathy-related genes.
Is 81448 a single-gene analysis?
No. It describes genomic sequencing of a panel of peripheral-neuropathy-related genes.
How does Medicare pay for 81448?
Medicare pays it through the CLFS only, using one national amount per code across localities and without an office-versus-facility payment difference.
How does 81448 differ from 81460?
81448 is a hereditary peripheral neuropathy panel; 81460 analyzes the whole mitochondrial genome.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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