CPT code 81450: Hematolymphoid panel, 5–50 genes, DNA or combined2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Genomic sequence analysis of 5–50 genes for a hematolymphoid neoplasm or disorder, reported for DNA-only or combined DNA and RNA testing.
Medicare pays $759.53 for 81450 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$759.53
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 81450 covers
Code 81450 represents genomic sequence analysis of a panel containing 5–50 genes for a hematolymphoid neoplasm or disorder. The panel may use DNA alone or combined DNA and RNA analysis. Depending on the assay, the analysis can evaluate sequence variants together with copy-number variants or rearrangements, or assess isoform or messenger RNA expression. It is a molecular laboratory test, and the code distinguishes this hematolymphoid panel from similarly sized solid-neoplasm panels and from hematolymphoid RNA-only panels. The gene count and analysis type are central to selecting the code.
Report one panel code for the qualifying analysis rather than separate units for individual genes. Use the corresponding sibling code when analysis is RNA alone or the gene count falls outside the 5–50 range. Medicare pays 81450 under the CLFS at one national amount across localities, without an office or facility payment difference. The 2026 national CLFS amount is $759.53, unchanged since 2020. The test is paid only through the CLFS.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 81450
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 81450. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 81450 with status X (excluded by statute), so the test itself is paid only from the CLFS.
81450 on the lab fee schedule since 2020
81450 · CLFS 2026 Q4 (current)
$759.53
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
81450 compared with similar tests
- 81451RNA gene panelHematolymphoid, 5–50 genes$759.53
- Both codes cover a 5–50-gene hematolymphoid neoplasm panel. Select 81450 for DNA or combined DNA and RNA analysis and 81451 for RNA analysis.
- 81455Tumor genomic panel51+ genes, DNA or DNA/RNA$2,919.60
- 81450 is for a 5–50-gene panel; 81455 is for a panel of 51 or more genes.
- 81445Tumor gene panel5–50 genes, DNA or DNA/RNA$597.91
- Both describe DNA or combined DNA and RNA analysis of 5–50 genes, but 81445 is for a solid neoplasm rather than a hematolymphoid neoplasm or disorder.
81450 billing questions
When should this code be chosen instead of 81451?
Use 81450 for a 5–50-gene panel using DNA analysis or combined DNA and RNA analysis. Code 81451 is for RNA analysis of a hematolymphoid neoplasm panel in the same gene-count range.
How does 81450 differ from 81455?
81450 applies to a 5–50-gene panel, while 81455 applies to a panel of 51 or more genes.
Are individual genes reported as separate units?
No. The gene count helps determine the applicable panel code; the genes analyzed are not separate units of 81450.
What documentation supports reporting this panel?
Document the hematolymphoid neoplasm or disorder being evaluated, the analysis type, and the number of genes in the panel.
How does Medicare pay for 81450?
Medicare pays 81450 under the CLFS at one national amount across localities, without an office or facility payment difference.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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