CPT code 82107: AFP-L3, fraction, total AFP, and ratio2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Measures the AFP-L3 fraction alongside total alpha-fetoprotein and their ratio to support clinical assessment of hepatocellular carcinoma.
Medicare pays $64.41 for 82107 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$64.41
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 82107 covers
This assay measures the AFP-L3 fraction alongside total alpha-fetoprotein and reports their ratio. It supports clinical assessment of hepatocellular carcinoma, including in patients with chronic liver disease or a liver mass. Clinical laboratories perform the assay and report results to the ordering clinician, often a hepatologist, oncologist, or provider managing liver disease or suspected liver cancer.
Report 82107 when the test includes AFP-L3 fraction, total AFP, and the ratio; it is distinct from a standalone serum AFP test and amniotic-fluid AFP. Medicare pays the test only through the CLFS, at one national amount across localities, with no office-versus-facility difference. The 2026 national CLFS amount is $64.41, unchanged since 2020.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 82107
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 82107. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 82107 with status X (excluded by statute), so the test itself is paid only from the CLFS.
82107 on the lab fee schedule since 2020
82107 · CLFS 2026 Q4 (current)
$64.41
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
82107 compared with similar tests
- 82105AFP testSerum$16.77
- Choose 82105 for standalone serum AFP. Choose 82107 when the assay measures AFP-L3 and includes total AFP and the ratio.
- 82106AFP testAmniotic fluid$17.00
- 82106 is for AFP testing in amniotic fluid. 82107 is for AFP-L3 fraction testing, not prenatal amniotic-fluid screening.
- 83951DCP testDes-gamma-carboxy prothrombin$64.41
- 83951 measures des-gamma-carboxy prothrombin, a different liver cancer biomarker. It is not a substitute for AFP-L3 fraction testing.
82107 billing questions
How does 82107 differ from 82105?
82107 reports the AFP-L3 fraction with total AFP and their ratio. Use 82105 for a standalone serum AFP assay.
Can 82105 also be reported for the total AFP in an AFP-L3 assay?
Do not report 82105 separately for the same total AFP measurement already included in the 82107 assay.
Is 82107 the code for amniotic-fluid AFP?
No. 82107 is for AFP-L3 fraction testing with total AFP and ratio; 82106 identifies amniotic-fluid AFP testing.
How does Medicare pay for 82107?
Medicare pays 82107 through the CLFS at one national amount across localities, without an office or facility payment difference.
Is a separate physician interpretation billed under the physician fee schedule?
No separate physician interpretation payment is billed under the physician fee schedule; Medicare pays 82107 only through the CLFS.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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