CPT code 82390: Ceruloplasmin, protein concentration2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Measures ceruloplasmin in blood to support evaluation of copper metabolism disorders, including Wilson disease, and unexplained liver or neurologic findings.
Medicare pays $10.74 for 82390 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$10.74
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 82390 covers
Ceruloplasmin testing measures the blood concentration of ceruloplasmin, a copper-carrying protein. Clinicians order it when evaluating suspected Wilson disease or another copper metabolism disorder, and may include it in workups of unexplained liver abnormalities or neurologic findings. The assay measures ceruloplasmin itself, not copper; copper testing may be ordered separately when both analytes are clinically relevant. Clinical laboratories perform and report the assay.
Report 82390 for the ceruloplasmin assay performed. Medicare pays the test only through the CLFS, using one national amount per code across states and localities, with no office-versus-facility payment difference. The 2026 national CLFS amount is $10.74, unchanged from 2020 through 2026.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 82390
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 82390. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 82390 with status X (excluded by statute), so the test itself is paid only from the CLFS.
82390 on the lab fee schedule since 2020
82390 · CLFS 2026 Q4 (current)
$10.74
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
82390 compared with similar tests
- 82525CopperCopper concentration$12.41
- Use 82390 for the ceruloplasmin protein concentration; use 82525 when the measured analyte is copper.
- 80076Liver panelSeven liver chemistry tests$8.17
- 82390 reports a specific protein assay. The hepatic function panel reports a group of liver-related laboratory measurements.
- 80053Metabolic panelFourteen blood chemistry tests$10.56
- 82390 measures ceruloplasmin alone, while the comprehensive metabolic panel reports a broader group of chemistry tests.
82390 billing questions
When should ceruloplasmin be reported instead of a copper assay?
Report 82390 when the test measures ceruloplasmin protein. A copper assay measures copper itself.
Can ceruloplasmin and copper testing be reported on the same encounter?
They measure different analytes and may both be reported when both tests are performed for the patient's evaluation.
Is ceruloplasmin included in a hepatic function panel?
No. Ceruloplasmin is a separate assay; the hepatic function panel reports a group of liver-related laboratory measurements.
How does Medicare pay this assay?
Medicare pays it only through the CLFS, with one nationally set amount across localities and no office-versus-facility payment difference.
What clinical documentation supports the assay?
Document the clinical reason for testing, such as evaluation of suspected Wilson disease, another copper metabolism disorder, unexplained liver abnormalities, or relevant neurologic findings.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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