CPT code 84080: Alkaline phosphatase, isoenzyme fractions2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Measures alkaline phosphatase isoenzymes to help identify the source of an elevated total result, especially when liver or bone contribution is under evaluation.
Medicare pays $14.78 for 84080 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$14.78
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 84080 covers
Alkaline phosphatase isoenzyme testing analyzes the enzyme’s forms to help localize an elevated total alkaline phosphatase result. Clinicians may order it when the total result is abnormal and its source is unclear, particularly when distinguishing a hepatobiliary from a bone contribution would guide evaluation. A clinical laboratory performs the assay and reports an isoenzyme analysis to the ordering clinician; it differs from measuring total alkaline phosphatase alone.
Report 84080 for the isoenzyme analysis, rather than total alkaline phosphatase measurement alone. Medicare pays this test under the CLFS. The 2026 national CLFS amount is $14.78, unchanged from 2020 through 2026. One amount applies across states and localities, with no geographic or office-versus-facility adjustment. Code 84080 is excluded from the physician fee schedule and paid only under the CLFS.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 84080
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 84080. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 84080 with status X (excluded by statute), so the test itself is paid only from the CLFS.
84080 on the lab fee schedule since 2020
84080 · CLFS 2026 Q4 (current)
$14.78
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
84080 compared with similar tests
- 84075Alkaline phosphatase$5.18
- 84075 is the total alkaline phosphatase assay. Choose 84080 when isoenzyme analysis is performed to help determine the enzyme’s source.
- 84060Acid phosphataseTotal enzyme activity$7.64
- 84060 measures acid phosphatase, a different enzyme. Use 84080 for alkaline phosphatase isoenzymes.
- 84066Acid phosphataseProstatic form$9.66
- 84066 measures prostate phosphatase. It is not the alkaline phosphatase isoenzyme assay reported with 84080.
84080 billing questions
When should 84080 be reported instead of 84075?
Report 84080 when the service measures alkaline phosphatase isoenzymes to help identify the source of an abnormal result. Code 84075 represents measurement of alkaline phosphatase without the isoenzyme analysis.
What clinical question does the isoenzyme test address?
It helps distinguish the tissue source of elevated alkaline phosphatase, commonly when clinicians are evaluating a possible liver or biliary versus bone source.
Is 84080 paid under the physician fee schedule?
No. Medicare pays 84080 only under the CLFS, at one national amount that applies across localities and settings.
Does the code describe a total alkaline phosphatase measurement?
No. It describes analysis of alkaline phosphatase isoenzymes. Use 84075 for the total enzyme measurement.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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