CPT code 87391: HIV antigen, HIV-2 antigen detection2026 Medicare lab fee · Clinical Laboratory Fee Schedule
An immunoassay that detects HIV-2 antigen, reported for testing directed at this antigen rather than HIV-1 antigen or HIV antibody.
Medicare pays $21.90 for 87391 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$21.90
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 87391 covers
87391 identifies a laboratory immunoassay that detects HIV-2 antigen. The assay may provide a qualitative or semiquantitative result. It is distinct from an HIV-1 antigen assay and from tests that detect HIV antibodies. Clinical laboratories perform and report the test when HIV-2 antigen detection is ordered.
Report 87391 for the HIV-2 antigen immunoassay. Medicare pays it only under the CLFS, at one nationally set amount that is the same across localities and in office and facility settings; it has no geographic adjustment. The 2026 national CLFS amount is $21.90, unchanged since 2020. The test is excluded from the physician fee schedule by statute and is paid only from the CLFS.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 87391
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 87391. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 87391 with status X (excluded by statute), so the test itself is paid only from the CLFS.
87391 on the lab fee schedule since 2020
87391 · CLFS 2026 Q4 (current)
$21.90
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
87391 compared with similar tests
- 87390HIV-1 antigenAntigen only$24.06
- Use 87391 for HIV-2 antigen detection and 87390 for HIV-1 antigen detection.
- 87389HIV screenHIV-1 antigen plus HIV-1/2 antibodies$24.08
- 87389 describes an assay for HIV-1 antigen and HIV-1/HIV-2 antibodies; 87391 detects HIV-2 antigen.
- 86702HIV antibodyHIV-2-specific$13.52
- 86702 detects HIV-2 antibodies. 87391 is for an assay that detects HIV-2 antigen.
87391 billing questions
How does 87391 differ from 87390?
87391 detects HIV-2 antigen, while 87390 detects HIV-1 antigen. The code selection follows the antigen the assay detects.
What targets are included in 87389?
87389 describes an assay for HIV-1 antigen and HIV-1/HIV-2 antibodies. 87391 is for HIV-2 antigen detection.
How does 87391 differ from HIV-2 antibody testing?
87391 detects HIV-2 antigen; 86702 detects HIV-2 antibodies. They represent different test targets.
Does 87391 include HIV antibody testing?
No. 87391 describes an immunoassay for HIV-2 antigen.
How does Medicare pay for 87391?
Medicare pays it only through the CLFS, at one national amount across localities and office and facility settings. It is excluded from the physician fee schedule by statute.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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