CPT code 88358: Tumor analysis, manual morphometry2026 Medicare rate & RVUs in Texas
Reports manual morphometric measurement of tumor tissue, such as analysis for DNA ploidy, when the analysis goes beyond routine microscopic examination.
Medicare pays $121.35–$135.91 for 88358 in the office in Texas, from Beaumont, TX to Austin, TX. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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On this page 9 sections
What 88358 covers
A pathologist uses manual morphometric methods to measure or evaluate features of tumor cells in a tissue specimen. A recognized example is analysis of tumor DNA ploidy. This is a specialized pathology service, not the routine microscopic examination used to diagnose and classify a biopsy or resection. It is generally performed in a pathology laboratory, with the pathologist interpreting the analysis and laboratory staff supporting the technical work.
Report the code when the documented tumor analysis is performed manually; distinguish it from computer-assisted tumor morphometry and from quantitative assessment of immunohistochemical staining. The record should identify the tumor material examined, the analysis performed, and the pathologist’s findings or interpretation. CMS recognizes a professional component for interpretation and a technical component for equipment and staff. Report modifier 26 for the professional component, modifier TC for the technical component, or neither modifier when billing the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where 88358 pays more and less in Texas
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
8 payment localities
$121.35 to $135.91
8 of 8 payment localities
| Payment locality | Office | Facility |
|---|---|---|
| Austin, TX | $135.91 | Unavailable |
| Beaumont, TX | $121.35 | Unavailable |
| Brazoria, TX | $129.41 | Unavailable |
| Dallas, TX | $130.01 | Unavailable |
| Fort Worth, TX | $129.04 | Unavailable |
| Galveston, TX | $129.65 | Unavailable |
| Houston, TX | $130.20 | Unavailable |
| Rest of Texas | $125.16 | Unavailable |
How the 88358 rate is calculated
Each of 88358’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88358
RVUs × geographic indexes × conversion factor
Work0.93
0.93 RVUs× 1.000 GPCI
Practice expense2.94
2.94 RVUs× 1.000 GPCI
Malpractice0.03
0.03 RVUs× 1.000 GPCI
Adjusted RVUs
3.9000
Conversion factor
$33.4009
Medicare rate
$130.26
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for 88358
The CMS indicators that decide how 88358 is paid alongside other services.
CMS payment indicators · 88358
Tumor analysis, manual morphometry
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88358 without 26 · national office
$130.26
Tumor analysis, manual morphometry
88358-26 · Professional component
$46.09
Pays only the interpretation and report.
88358 compared with similar codes
Compare codes · National
88358 vs 88360 vs 88361: Medicare rates
How to choose
- 88360Tumor IHC scoringManual quantitative, per antibody
- 88360 is for manual quantitative assessment of tumor immunohistochemical staining; 88358 is for manual morphometric analysis such as DNA ploidy.
- 88361Tumor immunohistochemistryComputer-assisted analysis
- 88361 covers computer-assisted quantitative assessment of tumor immunohistochemical staining, rather than the manual tumor morphometry reported with 88358.
88358 billing questions
How does this differ from computer-assisted tumor morphometry?
This code is for manual morphometric analysis. Use the computer-assisted sibling when the tumor measurement is performed with computer assistance.
Is routine tumor microscopy included in this service?
No. This code represents a specialized morphometric analysis, such as manual assessment for DNA ploidy, rather than routine microscopic examination of a biopsy or resection.
Which modifiers identify the professional and technical components?
Use modifier 26 for the pathologist’s interpretation and modifier TC for the equipment and staff component. Submit without either modifier for the global service.
What documentation supports reporting this code?
Document the tumor specimen or material analyzed, the manual morphometric method and purpose, and the resulting findings or interpretation.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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