CPT code 96406: Intralesional chemotherapy, more than seven lesions2026 Medicare rate & RVUs in Miami, FL

Reports administration of antineoplastic medication directly into more than seven lesions during treatment of multiple localized lesions.

CMS RVU26DEffective Oct 1, 2026One payment locality779 Medicare services in 2024

In Miami, FL, Medicare pays $139.23 for 96406 in the office and $40.83 when it’s performed in a hospital or facility.

$139.23Office (non-facility)
$40.83Hospital or facility
+5.5%vs the national office rate ($131.93)

Check a contract rate as a % of Medicare · 96406 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 96406 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Miami, FL
  2. What 96406 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 96406 covers

This service covers delivery of an antineoplastic medication directly into more than seven discrete lesions. Dermatology and oncology clinicians may perform it in an office or other treatment setting when lesions are treated individually by the intralesional route. The code reflects the number of lesions treated, not the number of injections, syringes, or medications used. It is distinct from systemic chemotherapy delivered by subcutaneous, intramuscular, intravenous, or other routes.

Select the code based on the documented lesion count: this level is for more than seven treated lesions, while 96405 is the lower-count sibling. Record the lesions treated, their sites, the medication, and the intralesional route. The medication is separate from the administration service when separately reportable. CMS assigns a 0-day global period, so same-day preoperative and postoperative care is included. When multiple procedures occur in the same session, the highest-valued procedure is paid in full and other procedures are subject to the standard 50% reduction. Modifier 50 is inappropriate; assistant-at-surgery payment is restricted, and co-surgeon and team-surgery billing are not permitted.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Miami, FL compares for 96406

Across 109 of 109 payment localities, the office rate for 96406 runs from $116.41 in Arkansas to $179.56 in San Benito County, CA. Miami, FL pays $139.23. The RVUs are the same everywhere; the geographic indexes change the dollars.

96406 in Miami, FL vs other payment areas
  1. Miami, FL · this page$139.23
  2. Fort Lauderdale, FL · Florida$134.89−$4.34
  3. Rest of Florida · Florida$128.40−$10.83
  4. Los Angeles, CA · California$151.24+$12.01
  5. Washington, DC area · District of Columbia$151.97+$12.74
  6. Chicago, IL · Illinois$135.23−$4.00
  7. Manhattan, NY · New York$151.54+$12.31

Other areas in Florida first, then benchmark localities. Bars start at $0.

Every other payment area

96406 in every other Medicare payment locality
Payment localityOfficeFacility
AlaskaAlaska$151.10$50.43
AlabamaAlabama$118.16$35.45
ArkansasArkansas$116.41$35.21
ArizonaArizona$128.45$36.85
Bakersfield, CACalifornia$141.57$37.97
Chico, CACalifornia$141.37$37.77
El Centro, CACalifornia$141.38$37.78
Fresno, CACalifornia$141.37$37.77

96406 rates by state

Office rate range in each state. Select a state to see its payment localities.

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$116.41

$160.47

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
96406 office rate range by state
State / territoryOffice rate rangeLocalities
AK$151.101
AL$118.161
AR$116.411
AZ$128.451
CA$141.37–$179.5629
CO$138.421
CT$140.841
DC$151.971
DE$130.631
FL$128.40–$139.233
GA$121.17–$134.072
GU$145.231
HI$145.231
IA$121.951
ID$122.621
IL$124.08–$136.454
IN$123.371
KS$121.031
KY$120.311
LA$119.98–$126.122
MA$137.42–$152.832
MD$133.27–$151.973
ME$122.92–$130.272
MI$123.21–$129.702
MN$133.521
MO$117.64–$126.983
MS$117.061
MT$131.931
NC$124.301
ND$130.741
NE$122.741
NH$135.911
NJ$142.69–$150.272
NM$123.771
NV$131.701
NY$126.18–$154.875
OH$122.971
OK$120.441
OR$130.93–$143.302
PA$123.36–$137.032
PR$133.041
RI$135.631
SC$123.791
SD$130.601
TN$121.611
TX$122.50–$137.748
UT$125.541
VA$129.59–$151.972
VI$133.041
VT$129.911
WA$137.27–$156.332
WI$126.211
WV$119.281
WY$131.411

See 96406 in every payment locality

How the 96406 rate is calculated

Each of 96406’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 96406

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.80

0.80 RVUs× 1.000 GPCI

Practice expense3.09

3.09 RVUs× 1.000 GPCI

Malpractice0.06

0.06 RVUs× 1.000 GPCI

Adjusted RVUs

3.9500

Conversion factor

$33.4009

Medicare rate

$131.93

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Miami, FL inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

12,798

Code
96406
Physician work
0.80
Practice expense
3.09
Malpractice
0.06

GPCI2026.csv

42

Locality
Miami, FL
Physician work
1.000
Practice expense
1.041
Malpractice
2.529
Office calculation for 96406 in Miami, FL
ComponentRVULocality factorAdjusted
Physician work0.80× 1.0000.8000
Practice expense3.09× 1.0413.2167
Malpractice0.06× 2.5290.1517
Total RVUs4.1684
Conversion factor× 33.4009

Office rate, Miami, FL$139.23

Office: (0.8 × 1 + 3.09 × 1.041 + 0.06 × 2.529) × $33.4009 = $139.23

Facility: (0.8 × 1 + 0.26 × 1.041 + 0.06 × 2.529) × $33.4009 = $40.83

Open 96406 in the RVU calculator

Payment rules and modifiers for 96406

The CMS indicators that decide how 96406 is paid alongside other services.

CMS payment indicators · 96406

Intralesional chemotherapy, more than seven lesions

RuleCMS valueWhat it means
Global period000Same-day global: pre- and post-op care on the day of the procedure is included.
Multiple procedures2Standard reduction: highest-valued procedure at 100%, others at 50%.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)1Not paid (statutory restriction).
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.

What modifiers do to the payment

Modifier 51 · payment effect

With and without the modifier

96406 without 51 · national office

$131.93

Intralesional chemotherapy, more than seven lesions

96406-51 · Second procedure: 50%

$65.97

When this isn’t the highest-valued procedure in the session, Medicare pays 50% of its fee schedule amount (the highest is paid at 100%).

When to use modifier 51

How 96406 has changed in Miami, FL

96406 · Office / nonfacility

$139.23

Effective 2026-10-01

The base rate is $12.78 higher than on 2025-10-01, moving from $126.45 to $139.23 (10.1%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release
  1. January 1, 2026

    RVU26A

    $126.45changed to$139.23

    • Conversion factor 32.3465 changed to 33.4009
    • Practice expense RVU 2.93 changed to 3.09
    • Malpractice RVU 0.04 changed to 0.06
    • Practice expense GPCI 1.027 changed to 1.041
    • Malpractice GPCI 2.500 changed to 2.529

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $135.21changed to$126.45

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 3.03 changed to 2.93
    • Malpractice RVU 0.06 changed to 0.04

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $133.00changed to$135.21

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $138.61changed to$133.00

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 3.06 changed to 3.03
    • Practice expense GPCI 1.025 changed to 1.027
    • Malpractice GPCI 2.564 changed to 2.500
  5. January 1, 2023

    RVU23A

    $143.80changed to$138.61

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 3.10 changed to 3.06
    • Malpractice RVU 0.07 changed to 0.06
    • Practice expense GPCI 1.023 changed to 1.025
    • Malpractice GPCI 2.629 changed to 2.564

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $141.37changed to$143.80

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 3.05 changed to 3.10
    • Malpractice RVU 0.05 changed to 0.07

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $136.32changed to$141.37

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 2.75 changed to 3.05
    • Malpractice RVU 0.06 changed to 0.05
    • Practice expense GPCI 1.026 changed to 1.023
    • Malpractice GPCI 2.598 changed to 2.629

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $130.80changed to$136.32

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 2.60 changed to 2.75
    • Practice expense GPCI 1.029 changed to 1.026
    • Malpractice GPCI 2.566 changed to 2.598

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $126.95changed to$130.80

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 2.50 changed to 2.60

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $126.86changed to$126.95

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 2.53 changed to 2.50
    • Malpractice RVU 0.05 changed to 0.06
    • Practice expense GPCI 1.031 changed to 1.029
    • Malpractice GPCI 2.528 changed to 2.566

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $123.35changed to$126.86

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense RVU 2.44 changed to 2.53
    • Practice expense GPCI 1.033 changed to 1.031
    • Malpractice GPCI 2.490 changed to 2.528

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $125.12changed to$123.35

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 2.50 changed to 2.44
    • Malpractice RVU 0.04 changed to 0.05

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $124.50changed to$125.12

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $119.60changed to$124.50

    • Conversion factor 35.8228 changed to 35.7547
    • Practice expense RVU 2.33 changed to 2.50
    • Practice expense GPCI 1.044 changed to 1.033
    • Malpractice GPCI 2.653 changed to 2.490

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $125.72changed to$119.60

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 2.64 changed to 2.33
    • Practice expense GPCI 1.054 changed to 1.044
    • Malpractice GPCI 2.815 changed to 2.653

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: $125.72

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$139.23$40.83RVU26D
2026-07-01$139.23$40.83RVU26C
2026-04-01$139.23$40.83RVU26B
2026-01-01$139.23$40.83RVU26A
2025-10-01$126.45$45.06RVU25D
2025-07-01$126.45$45.06RVU25C
2025-04-01$126.45$45.06RVU25B
2025-01-01$126.45$45.06RVU25A
2024-10-01$135.21$47.35RVU24D
2024-07-01$135.21$47.35RVU24C
2024-04-01$135.21$47.35RVU24B
2024-03-09$135.21$47.35RVU24AR
2024-01-01$133.00$46.58RVU24A
2023-10-01$138.61$48.30RVU23D
2023-07-01$138.61$48.30RVU23C
2023-04-01$138.61$48.30RVU23B
2023-01-01$138.61$48.30RVU23A
2022-10-01$143.80$49.63RVU22D
2022-07-01$143.80$49.63RVU22C
2022-04-01$143.80$49.63RVU22B
2022-01-01$143.80$49.63RVU22A
2021-10-01$141.37$48.56RVU21D
2021-07-01$141.37$48.56RVU21C
2021-04-01$141.37$48.56RVU21B
2021-01-01$141.37$48.56RVU21A
2020-10-01$136.32$51.16RVU20D
2020-07-01$136.32$51.16RVU20C
2020-04-01$136.32$51.16RVU20B
2020-01-01$136.32$51.16RVU20A
2019-10-01$130.80$51.07RVU19D
2019-07-01$130.80$51.07RVU19C
2019-04-01$130.80$51.07RVU19B
2019-01-01$130.80$51.07RVU19A
2018-10-01$126.95$51.38RVU18D
2018-07-01$126.95$51.38RVU18C
2018-04-01$126.95$51.38RVU18B
2018-01-01$126.95$51.38RVU18AR1
2017-10-01$126.86$50.64RVU17D
2017-07-01$126.86$50.64RVU17C
2017-04-01$126.86$50.64RVU17B
2017-01-01$126.86$50.64RVU17A
2016-10-01$123.35$50.48RVU16D
2016-07-01$123.35$50.48RVU16C
2016-04-01$123.35$50.48RVU16B
2016-01-01$123.35$50.48RVU16A
2015-10-01$125.12$49.77RVU15D
2015-07-01$125.12$49.77RVU15C
2015-04-01$124.50$49.52RVU15B
2015-01-01$124.50$49.52RVU15A
2014-10-01$119.60$49.66RVU14D
2014-07-01$119.60$49.66RVU14C
2014-04-01$119.60$49.66RVU14B
2014-01-01$119.60$49.66RVU14A
2013-10-01$125.72$48.62RVU13D
2013-07-01$125.72$48.62RVU13C
2013-04-01$125.72$48.62RVU13B
2013-01-01$125.72$48.62RVU13AR

Price 96406 for an earlier date of service

Where the Miami, FL rate applies

Miami, FL is a Medicare payment area, not a city. Our Census mapping connects it to 83 cities and communities in Florida. Some span more than one payment area; confirm with the service ZIP.

  • Miami
  • Aventura
  • Bal Harbour
  • Bay Harbor Islands
  • Big Coppitt Key
  • Big Pine Key
  • Biscayne Gardens
  • Biscayne Park

Browse all communities in Florida

96406 billing questions

How is this code distinguished from 96405?

Use this code when more than seven lesions are treated intralesionally. Use 96405 for seven or fewer treated lesions.

Are units based on injections or lesions?

The threshold is based on the number of lesions treated, not the number of needle entries or syringes. Document the treated lesion count and sites.

Is the antineoplastic medication included?

This code reports the administration service, not the medication itself. Report the drug separately when it is separately reportable.

Can modifier 50 be used for lesions on both sides?

No. CMS identifies modifier 50 as inappropriate for this service; treatment of lesions on both sides does not make it a bilateral procedure.

How does the same-session multiple-procedure rule affect payment?

When multiple procedures are performed in the same session, the highest-valued procedure is paid in full and the others are subject to the standard 50% reduction.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 96406PPRRVU2026_Oct_nonQPP.csv, line 12,798 (RVU26D)
Geographic factors for Miami, FLGPCI2026.csv, line 42 (RVU26D)

Open CMS sourceHow we calculate rates

Did this answer your question about what 96406 pays in Miami, FL?

Tell us what you were actually trying to work out. We’ll answer you directly, or build the page that does.

Fee sheets · Coming soon

Put 96406 and the rest of your codes on one sheet

Your codes at your locality, with payer contracts beside Medicare.

Join the waitlist