HCPCS code G0327: Blood-based screening, colorectal cancer biomarker2026 Medicare lab fee · Clinical Laboratory Fee Schedule
G0327 reports colorectal cancer screening with a blood-based biomarker, distinguishing this laboratory test from fecal immunoassay and endoscopic screening services.
Medicare has no national amount for G0327: it’s on the 2026 Clinical Laboratory Fee Schedule as contractor-priced, so each Medicare Administrative Contractor sets the payment.
Medicare lab fee · CLFS 2026 Q4
Contractor-priced (CLFS indicator L)
Set by your MAC
CMS lists G0327 on the Clinical Laboratory Fee Schedule without a national amount: each Medicare Administrative Contractor prices it for its jurisdiction.
- National amount
- None
- Priced by
- Each MAC
- Fee schedule
- Clinical lab
- CMS updates
- Quarterly
The contractor that processes the claim sets the amount for its jurisdiction. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 7 sections
What G0327 covers
G0327 identifies a colorectal cancer screening test that uses a blood-based biomarker. A clinician may order it as a screening option. The laboratory performs the test using a blood specimen and reports the screening result to the ordering clinician. This code distinguishes blood-based biomarker screening from fecal blood testing and endoscopic screening procedures. It is reported for the screening test, not for colonoscopy or flexible sigmoidoscopy.
Report G0327 for the blood-based biomarker screening service. Medicare pays it under the CLFS, with each Medicare Administrative Contractor setting the locally priced amount. The CLFS payment has no office-versus-facility difference and no GPCI adjustment. G0327 is excluded from the physician fee schedule by statute and is paid only from the CLFS.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays G0327
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
Priced by each contractor
G0327 carries CLFS indicator L: CMS publishes no national amount, and each Medicare Administrative Contractor sets the payment for its jurisdiction. Ask your MAC for its current amount.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists G0327 with status X (excluded by statute), so the test itself is paid only from the CLFS.
G0327 compared with similar tests
- G0328FIT screeningOne to three simultaneous tests$18.05
- G0327 identifies a blood-based biomarker screening test. G0328 identifies fecal blood screening by immunoassay.
- G0104Flexible sigmoidoscopyColorectal cancer screening$187.08–$297.27
- G0104 reports a screening flexible sigmoidoscopy, an endoscopic service. G0327 reports a laboratory blood-based screening test.
- G0105Screening colonoscopyHigh-risk individual$335.05–$497.55
- G0105 reports screening colonoscopy for a patient at high risk. G0327 reports blood-based biomarker screening, not an endoscopic procedure.
- G0121Screening colonoscopyNot high risk$335.22–$497.73
- G0121 reports screening colonoscopy for a patient at average risk. G0327 reports a blood-based biomarker screening test.
G0327 billing questions
When should G0327 be used instead of G0328?
Use G0327 for colorectal cancer screening with a blood-based biomarker. G0328 identifies a fecal blood screening test performed by immunoassay.
Is G0327 a laboratory test or an endoscopic service?
G0327 reports a laboratory blood-based biomarker screening test. It does not report colonoscopy or flexible sigmoidoscopy.
How does Medicare pay G0327?
Medicare pays G0327 under the CLFS, with each Medicare Administrative Contractor setting the locally priced amount. Payment has no office-versus-facility difference.
Is G0327 paid under the physician fee schedule?
No. G0327 is excluded from the physician fee schedule by statute and is paid only from the CLFS.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
Fee sheets · Coming soon
Put G0327 and the rest of your codes on one sheet
Your codes at your locality, with payer contracts beside Medicare.
Join the waitlist