HCPCS code Q4315: Amniotic allograft, regenelink product2026 Medicare rate & RVUs in Missouri
Report Q4315 for Regenelink amniotic membrane allograft used with a primary wound-treatment procedure, with units supported by the amount applied.
Medicare pays $109.70–$121.15 for Q4315 in the office in Missouri, from Rest of Missouri to Metropolitan St. Louis, MO. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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On this page 9 sections
What Q4315 covers
Q4315 identifies the Regenelink amniotic membrane allograft supplied for wound treatment. The graft is placed over a prepared wound as a covering or adjunct to wound care. Wound-care clinicians, podiatrists, and surgeons may use amniotic membrane products in outpatient settings for wounds such as diabetic foot ulcers or venous leg ulcers; the specific product documented must be Regenelink for this code to apply.
Report Q4315 with the primary procedure for the graft application; CMS classifies it as an add-on code paid within that procedure’s global period. The record should identify the product, wound site, application procedure, and amount applied, with units reflecting the product’s per-square-centimeter billing basis. CMS classifies this code as technical-component-only, with interpretation covered by a separate code. The Q4315 line represents the product’s technical portion, not interpretation.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where Q4315 pays more and less in Missouri
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
3 payment localities
$109.70 to $121.15
| Payment locality | Office | Facility |
|---|---|---|
| Metropolitan Kansas City, MO | $119.49 | Unavailable |
| Metropolitan St. Louis, MO | $121.15 | Unavailable |
| Rest of Missouri | $109.70 | Unavailable |
How the Q4315 rate is calculated
Each of Q4315’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · Q4315
RVUs × geographic indexes × conversion factor
Work0.00
0.00 RVUs× 1.000 GPCI
Practice expense3.81
3.81 RVUs× 1.000 GPCI
Malpractice0.00
0.00 RVUs× 1.000 GPCI
Adjusted RVUs
3.8100
Conversion factor
$33.4009
Medicare rate
$127.26
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for Q4315
The CMS indicators that decide how Q4315 is paid alongside other services.
CMS payment indicators · Q4315
Amniotic allograft, regenelink product
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 3 | Technical component only. |
Q4315 compared with similar codes
Compare codes · National
4 codes, side by side
How to choose
- Q4314Wound productReeva, per square centimeter
- Q4314 identifies Reeva, while Q4315 identifies Regenelink. Select the code matching the product documented as supplied and applied.
- Q4316Wound graftAmchoplast, per square centimeter
- Q4316 identifies Amchoplast rather than Regenelink. These product codes are not interchangeable based solely on both being amniotic membrane products.
- 15271Skin substitute graftFirst 25 cm², trunk/limbs
- 15271 reports the application procedure for qualifying grafts on trunk, arms, or legs; Q4315 identifies the Regenelink product supplied with a primary procedure.
Q4315 billing questions
When should Q4315 be selected instead of another amniotic membrane product code?
Use Q4315 when the product supplied and applied is Regenelink. Choose another product-specific code when the record identifies a different product; the general tissue type alone does not determine the code.
Can Q4315 be reported without a wound-application procedure?
No. CMS identifies Q4315 as an add-on code that must be billed with a primary procedure, and its payment falls within that procedure’s global period.
How should units for Q4315 be supported?
Document the wound site and the amount of Regenelink applied. Report units on the code’s per-square-centimeter basis.
Does Q4315 include interpretation?
No. CMS classifies Q4315 as technical-component-only and indicates that a separate code covers interpretation.
What documentation supports reporting Q4315?
The record should identify Regenelink by product name, describe the treated wound and application, and support the quantity reported. It should also show the primary procedure billed with the add-on code.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
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