HCPCS code Q4388: Wound product, neothelium 4L, per square centimeter2026 Medicare rate & RVUs in Michigan
Q4388 identifies Neothelium 4L wound product by square centimeter when supplied for application during a wound procedure.
Medicare pays $116.19–$122.80 for Q4388 in the office in Michigan, from Rest of Michigan to Detroit, MI. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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On this page 9 sections
What Q4388 covers
Q4388 represents the Neothelium 4L product supplied for wound treatment, measured by square centimeter. It is typically associated with application to a wound, such as a chronic diabetic foot ulcer or venous leg ulcer, by a wound-care clinician, podiatrist, or surgeon in an office or hospital outpatient setting. The code identifies the product, not the clinical assessment or wound-preparation work.
Report the number of square centimeters represented by the product supplied, and retain documentation identifying the product, wound site, treated area, and amount used. Q4388 is an add-on code: report it only with a primary procedure, and its payment is within that procedure’s global period. CMS classifies it as technical-component-only; a separate code covers interpretation. Neothelium 4L is distinct from other Neothelium product variants, so use the product identification and applicable code rather than selecting by brand name alone.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where Q4388 pays more and less in Michigan
| Payment locality | Office | Facility |
|---|---|---|
| Detroit, MI | $122.80 | Unavailable |
| Rest of Michigan | $116.19 | Unavailable |
How the Q4388 rate is calculated
Each of Q4388’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · Q4388
RVUs × geographic indexes × conversion factor
Work0.00
0.00 RVUs× 1.000 GPCI
Practice expense3.81
3.81 RVUs× 1.000 GPCI
Malpractice0.00
0.00 RVUs× 1.000 GPCI
Adjusted RVUs
3.8100
Conversion factor
$33.4009
Medicare rate
$127.26
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for Q4388
The CMS indicators that decide how Q4388 is paid alongside other services.
CMS payment indicators · Q4388
Wound product, neothelium 4L, per square centimeter
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 3 | Technical component only. |
Q4388 compared with similar codes
Compare codes · National
4 codes, side by side
How to choose
- Q4387Skin substituteNeothelium FT, per square centimeter
- Q4387 identifies Neothelium FT; Q4388 identifies Neothelium 4L. Match the code to the product variant supplied.
- Q4389Wound matrixNeothelium 4L+
- Q4389 identifies Neothelium 4L+, not Neothelium 4L. The shared brand does not make the product codes interchangeable.
- 15271Skin substitute graftFirst 25 cm², trunk/limbs
- 15271 reports the application procedure for qualifying wounds on the trunk, arms, or legs. Q4388 identifies the Neothelium 4L product supplied with a primary procedure.
Q4388 billing questions
Can Q4388 be reported by itself?
No. CMS identifies it as an add-on code, so it must be reported with a primary procedure.
How are units determined?
The descriptor is per square centimeter. Document the wound area treated and the amount of Neothelium 4L supplied.
How does Q4388 differ from Q4387?
Both identify Neothelium products, but Q4388 is the 4L variant and Q4387 is Neothelium FT. Select the code matching the product supplied.
How does Q4388 differ from Q4389?
Q4389 identifies Neothelium 4L+, a separately coded variant. Do not substitute it for Q4388 based only on the shared Neothelium name.
Does Q4388 include interpretation?
No. CMS classifies Q4388 as technical-component-only, with interpretation represented by a separate code.
What documentation supports Q4388?
Record the product as Neothelium 4L, the wound location and treated area, and the quantity supplied in square centimeters.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
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