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CMS RVU26D · Effective 2026-10-01

Q4101 in Wyoming**

Office / nonfacility

$127.26

Base rate per service

Facility setting

Not available in this setting

Base rate per service

Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.

Wound care

About Q4101: Apligraf skin substitute supply

Q4101 reports Apligraf supplied for wound treatment, measured by area and billed with the procedure used to apply the product.

Q4101 represents Apligraf, a living skin substitute used to support healing of chronic wounds such as venous leg ulcers and diabetic foot ulcers. Wound-care physicians, surgeons, podiatrists, and other clinicians may apply it in outpatient wound clinics or other settings where these wounds are treated. The code represents the product, not the clinician’s application service.

Report the quantity based on the square centimeters of Apligraf supplied, and document the wound, product used, and amount applied. Q4101 is an add-on code: report it only with a primary application procedure, and its payment falls within that procedure’s global period. CMS assigns no physician work RVUs and assigns practice-expense RVUs. CMS classifies Q4101 as technical-component-only; a separate code covers interpretation.

CMS billing rules for Q4101

Global period
Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
Professional and technical components
Technical-component-only code: a separate code covers interpretation.

Where the value comes from

  • Work RVU0.00 · 0%
  • Practice expense (office) RVU3.81 · 100%
  • Malpractice RVU0.00 · 0%

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Q4101 compared with similar codes

Office rates for Wyoming**, from the same CMS release.

15271

Skin substitute graft

First 25 cm², trunk/limbs

$156.16

15271 reports the application procedure for qualifying trunk and extremity wounds; Q4101 reports the Apligraf product used with that procedure.

15275

Skin substitute

Face and other specified sites

$158.59

15275 reports the application procedure for qualifying wounds at specified sites such as the head, neck, hands, feet, or genitalia; Q4101 reports the product.

Q4102

Wound matrix

Oasis wound matrix

$127.26

Q4102 identifies Oasis wound matrix, not Apligraf. Select the product code that matches the skin substitute supplied.

The same code, a different location

How does Wyoming** compare?

Q4101 across payment areas

Same release and payment basis · bars start at $0

  1. Wyoming** · This locality

    $127.26

  2. Los Angeles-Long Beach-Anaheim (Los Angeles/Orange Cnty)

    $150.55

    $23.29 higher than Wyoming**

  3. Dc + Md/Va Suburbs

    $149.91

    $22.65 higher than Wyoming**

  4. Miami

    $132.47

    $5.21 higher than Wyoming**

  5. Chicago

    $127.89

    $0.63 higher than Wyoming**

  6. Manhattan

    $147.87

    $20.61 higher than Wyoming**

  7. Alaska*

    $135.53

    $8.27 higher than Wyoming**

Other payment areas listed in Wyoming appear first, followed by selected cross-country examples. The chart compares amounts, not distance.

Across 109 of 109 CMS payment localities with a supported office rate, Q4101 ranges from $109.31 in Arkansas to $183.51 in San Jose-Sunnyvale-Santa Clara (Santa Clara Cnty). This is a geographic range, not an average.

The code’s RVUs stay the same in these comparisons. Geographic adjustments to work, practice expense and malpractice change the dollar amount. A city name alone may not identify the payment area for a service address.

Compare all 108 other payment areas

  • Alabama

    Alabama · Q4101

    Office

    $111.35

    Facility

    Unavailable

    $15.91 lower than Wyoming** for the office setting.

  • Arkansas

    Arkansas · Q4101

    Office

    $109.31

    Facility

    Unavailable

    $17.95 lower than Wyoming** for the office setting.

  • Arizona

    Arizona · Q4101

    Office

    $123.31

    Facility

    Unavailable

    $3.95 lower than Wyoming** for the office setting.

  • Bakersfield

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Chico

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • El Centro

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Fresno

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Hanford-Corcoran

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Madera

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Merced

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Modesto

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Napa

    California · Q4101

    Office

    $167.73

    Facility

    Unavailable

    $40.47 higher than Wyoming** for the office setting.

  • Oxnard-Thousand Oaks-Ventura

    California · Q4101

    Office

    $150.42

    Facility

    Unavailable

    $23.16 higher than Wyoming** for the office setting.

  • Redding

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Rest Of California

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Riverside-San Bernardino-Ontario

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Sacramento-Roseville-Folsom

    California · Q4101

    Office

    $148.00

    Facility

    Unavailable

    $20.74 higher than Wyoming** for the office setting.

  • Salinas

    California · Q4101

    Office

    $147.49

    Facility

    Unavailable

    $20.23 higher than Wyoming** for the office setting.

  • San Diego-Chula Vista-Carlsbad

    California · Q4101

    Office

    $152.20

    Facility

    Unavailable

    $24.94 higher than Wyoming** for the office setting.

  • San Francisco-Oakland-Berkeley (Marin Cnty)

    California · Q4101

    Office

    $179.43

    Facility

    Unavailable

    $52.17 higher than Wyoming** for the office setting.

  • San Francisco-Oakland-Berkeley (San Francisco/San Mateo/Alameda/Contra Costa Cnty)

    California · Q4101

    Office

    $179.43

    Facility

    Unavailable

    $52.17 higher than Wyoming** for the office setting.

  • San Jose-Sunnyvale-Santa Clara (San Benito Cnty)

    California · Q4101

    Office

    $183.51

    Facility

    Unavailable

    $56.25 higher than Wyoming** for the office setting.

  • San Jose-Sunnyvale-Santa Clara (Santa Clara Cnty)

    California · Q4101

    Office

    $183.51

    Facility

    Unavailable

    $56.25 higher than Wyoming** for the office setting.

  • San Luis Obispo-Paso Robles

    California · Q4101

    Office

    $144.95

    Facility

    Unavailable

    $17.69 higher than Wyoming** for the office setting.

  • Santa Cruz-Watsonville

    California · Q4101

    Office

    $154.62

    Facility

    Unavailable

    $27.36 higher than Wyoming** for the office setting.

  • Santa Maria-Santa Barbara

    California · Q4101

    Office

    $148.38

    Facility

    Unavailable

    $21.12 higher than Wyoming** for the office setting.

  • Santa Rosa-Petaluma

    California · Q4101

    Office

    $156.27

    Facility

    Unavailable

    $29.01 higher than Wyoming** for the office setting.

  • Stockton

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Vallejo

    California · Q4101

    Office

    $167.73

    Facility

    Unavailable

    $40.47 higher than Wyoming** for the office setting.

  • Visalia

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Yuba City

    California · Q4101

    Office

    $139.47

    Facility

    Unavailable

    $12.21 higher than Wyoming** for the office setting.

  • Colorado

    Colorado · Q4101

    Office

    $135.40

    Facility

    Unavailable

    $8.14 higher than Wyoming** for the office setting.

  • Connecticut

    Connecticut · Q4101

    Office

    $137.06

    Facility

    Unavailable

    $9.80 higher than Wyoming** for the office setting.

  • Delaware

    Delaware · Q4101

    Office

    $125.73

    Facility

    Unavailable

    $1.53 lower than Wyoming** for the office setting.

  • Fort Lauderdale

    Florida · Q4101

    Office

    $128.91

    Facility

    Unavailable

    $1.65 higher than Wyoming** for the office setting.

  • Rest Of Florida

    Florida · Q4101

    Office

    $121.66

    Facility

    Unavailable

    $5.60 lower than Wyoming** for the office setting.

  • Atlanta

    Georgia · Q4101

    Office

    $129.29

    Facility

    Unavailable

    $2.03 higher than Wyoming** for the office setting.

  • Rest Of Georgia

    Georgia · Q4101

    Office

    $113.51

    Facility

    Unavailable

    $13.75 lower than Wyoming** for the office setting.

  • Hawaii, Guam

    Hawaii · Q4101

    Office

    $144.69

    Facility

    Unavailable

    $17.43 higher than Wyoming** for the office setting.

  • Iowa

    Iowa · Q4101

    Office

    $116.44

    Facility

    Unavailable

    $10.82 lower than Wyoming** for the office setting.

  • Idaho

    Idaho · Q4101

    Office

    $117.08

    Facility

    Unavailable

    $10.18 lower than Wyoming** for the office setting.

  • East St. Louis

    Illinois · Q4101

    Office

    $117.08

    Facility

    Unavailable

    $10.18 lower than Wyoming** for the office setting.

  • Rest Of Illinois

    Illinois · Q4101

    Office

    $116.19

    Facility

    Unavailable

    $11.07 lower than Wyoming** for the office setting.

  • Suburban Chicago

    Illinois · Q4101

    Office

    $130.69

    Facility

    Unavailable

    $3.43 higher than Wyoming** for the office setting.

  • Indiana

    Indiana · Q4101

    Office

    $117.97

    Facility

    Unavailable

    $9.29 lower than Wyoming** for the office setting.

  • Kansas

    Kansas · Q4101

    Office

    $115.04

    Facility

    Unavailable

    $12.22 lower than Wyoming** for the office setting.

  • Kentucky

    Kentucky · Q4101

    Office

    $113.13

    Facility

    Unavailable

    $14.13 lower than Wyoming** for the office setting.

  • New Orleans

    Louisiana · Q4101

    Office

    $119.75

    Facility

    Unavailable

    $7.51 lower than Wyoming** for the office setting.

  • Rest Of Louisiana

    Louisiana · Q4101

    Office

    $112.62

    Facility

    Unavailable

    $14.64 lower than Wyoming** for the office setting.

  • Metropolitan Boston

    Massachusetts · Q4101

    Office

    $151.95

    Facility

    Unavailable

    $24.69 higher than Wyoming** for the office setting.

  • Rest Of Massachusetts

    Massachusetts · Q4101

    Office

    $134.00

    Facility

    Unavailable

    $6.74 higher than Wyoming** for the office setting.

  • Baltimore/Surr. Cntys

    Maryland · Q4101

    Office

    $136.55

    Facility

    Unavailable

    $9.29 higher than Wyoming** for the office setting.

  • Rest Of Maryland

    Maryland · Q4101

    Office

    $128.78

    Facility

    Unavailable

    $1.52 higher than Wyoming** for the office setting.

  • Rest Of Maine

    Maine · Q4101

    Office

    $117.08

    Facility

    Unavailable

    $10.18 lower than Wyoming** for the office setting.

  • Southern Maine

    Maine · Q4101

    Office

    $126.11

    Facility

    Unavailable

    $1.15 lower than Wyoming** for the office setting.

  • Detroit

    Michigan · Q4101

    Office

    $122.80

    Facility

    Unavailable

    $4.46 lower than Wyoming** for the office setting.

  • Rest Of Michigan

    Michigan · Q4101

    Office

    $116.19

    Facility

    Unavailable

    $11.07 lower than Wyoming** for the office setting.

  • Minnesota

    Minnesota · Q4101

    Office

    $130.95

    Facility

    Unavailable

    $3.69 higher than Wyoming** for the office setting.

  • Metropolitan Kansas City

    Missouri · Q4101

    Office

    $119.49

    Facility

    Unavailable

    $7.77 lower than Wyoming** for the office setting.

  • Metropolitan St. Louis

    Missouri · Q4101

    Office

    $121.15

    Facility

    Unavailable

    $6.11 lower than Wyoming** for the office setting.

  • Rest Of Missouri

    Missouri · Q4101

    Office

    $109.70

    Facility

    Unavailable

    $17.56 lower than Wyoming** for the office setting.

  • Mississippi

    Mississippi · Q4101

    Office

    $109.57

    Facility

    Unavailable

    $17.69 lower than Wyoming** for the office setting.

  • Montana**

    Montana · Q4101

    Office

    $127.26

    Facility

    Unavailable

    The same base rate than Wyoming** for the office setting.

  • North Carolina

    North Carolina · Q4101

    Office

    $118.73

    Facility

    Unavailable

    $8.53 lower than Wyoming** for the office setting.

  • North Dakota**

    North Dakota · Q4101

    Office

    $127.26

    Facility

    Unavailable

    The same base rate than Wyoming** for the office setting.

  • Nebraska

    Nebraska · Q4101

    Office

    $117.46

    Facility

    Unavailable

    $9.80 lower than Wyoming** for the office setting.

  • New Hampshire

    New Hampshire · Q4101

    Office

    $132.47

    Facility

    Unavailable

    $5.21 higher than Wyoming** for the office setting.

  • Northern Nj

    New Jersey · Q4101

    Office

    $147.62

    Facility

    Unavailable

    $20.36 higher than Wyoming** for the office setting.

  • Rest Of New Jersey

    New Jersey · Q4101

    Office

    $138.97

    Facility

    Unavailable

    $11.71 higher than Wyoming** for the office setting.

  • New Mexico

    New Mexico · Q4101

    Office

    $116.70

    Facility

    Unavailable

    $10.56 lower than Wyoming** for the office setting.

  • Nevada**

    Nevada · Q4101

    Office

    $127.38

    Facility

    Unavailable

    $0.12 higher than Wyoming** for the office setting.

  • Nyc Suburbs/Long Island

    New York · Q4101

    Office

    $151.31

    Facility

    Unavailable

    $24.05 higher than Wyoming** for the office setting.

  • Poughkpsie/N Nyc Suburbs

    New York · Q4101

    Office

    $139.35

    Facility

    Unavailable

    $12.09 higher than Wyoming** for the office setting.

  • Queens

    New York · Q4101

    Office

    $150.42

    Facility

    Unavailable

    $23.16 higher than Wyoming** for the office setting.

  • Rest Of New York

    New York · Q4101

    Office

    $120.89

    Facility

    Unavailable

    $6.37 lower than Wyoming** for the office setting.

  • Ohio

    Ohio · Q4101

    Office

    $116.19

    Facility

    Unavailable

    $11.07 lower than Wyoming** for the office setting.

  • Oklahoma

    Oklahoma · Q4101

    Office

    $113.64

    Facility

    Unavailable

    $13.62 lower than Wyoming** for the office setting.

  • Portland

    Oregon · Q4101

    Office

    $141.38

    Facility

    Unavailable

    $14.12 higher than Wyoming** for the office setting.

  • Rest Of Oregon

    Oregon · Q4101

    Office

    $126.75

    Facility

    Unavailable

    $0.51 lower than Wyoming** for the office setting.

  • Metropolitan Philadelphia

    Pennsylvania · Q4101

    Office

    $132.47

    Facility

    Unavailable

    $5.21 higher than Wyoming** for the office setting.

  • Rest Of Pennsylvania

    Pennsylvania · Q4101

    Office

    $116.82

    Facility

    Unavailable

    $10.44 lower than Wyoming** for the office setting.

  • Puerto Rico

    Puerto Rico · Q4101

    Office

    $128.66

    Facility

    Unavailable

    $1.40 higher than Wyoming** for the office setting.

  • Rhode Island

    Rhode Island · Q4101

    Office

    $131.46

    Facility

    Unavailable

    $4.20 higher than Wyoming** for the office setting.

  • South Carolina

    South Carolina · Q4101

    Office

    $117.59

    Facility

    Unavailable

    $9.67 lower than Wyoming** for the office setting.

  • South Dakota**

    South Dakota · Q4101

    Office

    $127.26

    Facility

    Unavailable

    The same base rate than Wyoming** for the office setting.

  • Tennessee

    Tennessee · Q4101

    Office

    $115.68

    Facility

    Unavailable

    $11.58 lower than Wyoming** for the office setting.

  • Austin

    Texas · Q4101

    Office

    $134.64

    Facility

    Unavailable

    $7.38 higher than Wyoming** for the office setting.

  • Beaumont

    Texas · Q4101

    Office

    $115.80

    Facility

    Unavailable

    $11.46 lower than Wyoming** for the office setting.

  • Brazoria

    Texas · Q4101

    Office

    $126.11

    Facility

    Unavailable

    $1.15 lower than Wyoming** for the office setting.

  • Dallas

    Texas · Q4101

    Office

    $126.75

    Facility

    Unavailable

    $0.51 lower than Wyoming** for the office setting.

  • Fort Worth

    Texas · Q4101

    Office

    $125.48

    Facility

    Unavailable

    $1.78 lower than Wyoming** for the office setting.

  • Galveston

    Texas · Q4101

    Office

    $126.37

    Facility

    Unavailable

    $0.89 lower than Wyoming** for the office setting.

  • Houston

    Texas · Q4101

    Office

    $126.37

    Facility

    Unavailable

    $0.89 lower than Wyoming** for the office setting.

  • Rest Of Texas

    Texas · Q4101

    Office

    $120.77

    Facility

    Unavailable

    $6.49 lower than Wyoming** for the office setting.

  • Utah

    Utah · Q4101

    Office

    $119.62

    Facility

    Unavailable

    $7.64 lower than Wyoming** for the office setting.

  • Virginia

    Virginia · Q4101

    Office

    $125.09

    Facility

    Unavailable

    $2.17 lower than Wyoming** for the office setting.

  • Virgin Islands

    United States Virgin Islands · Q4101

    Office

    $128.66

    Facility

    Unavailable

    $1.40 higher than Wyoming** for the office setting.

  • Vermont

    Vermont · Q4101

    Office

    $125.98

    Facility

    Unavailable

    $1.28 lower than Wyoming** for the office setting.

  • Rest Of Washington

    Washington · Q4101

    Office

    $134.00

    Facility

    Unavailable

    $6.74 higher than Wyoming** for the office setting.

  • Seattle (King Cnty)

    Washington · Q4101

    Office

    $156.14

    Facility

    Unavailable

    $28.88 higher than Wyoming** for the office setting.

  • Wisconsin

    Wisconsin · Q4101

    Office

    $121.91

    Facility

    Unavailable

    $5.35 lower than Wyoming** for the office setting.

  • West Virginia

    West Virginia · Q4101

    Office

    $110.59

    Facility

    Unavailable

    $16.67 lower than Wyoming** for the office setting.

See how rates vary across the country

Q4101 · Office / nonfacility · Non-QP. Choose a state to explore its payment localities. A range means the amount varies within that state.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$109.31

$161.49

Color shows the midpoint of each state’s locality range.

View all state and territory rates as a table
State / territoryRate rangeLocalities
AK$135.531
AL$111.351
AR$109.311
AZ$123.311
CA$139.47–$183.5129
CO$135.401
CT$137.061
DC$149.911
DE$125.731
FL$121.66–$132.473
GA$113.51–$129.292
GU$144.691
HI$144.691
IA$116.441
ID$117.081
IL$116.19–$130.694
IN$117.971
KS$115.041
KY$113.131
LA$112.62–$119.752
MA$134.00–$151.952
MD$128.78–$149.913
ME$117.08–$126.112
MI$116.19–$122.802
MN$130.951
MO$109.70–$121.153
MS$109.571
MT$127.261
NC$118.731
ND$127.261
NE$117.461
NH$132.471
NJ$138.97–$147.622
NM$116.701
NV$127.381
NY$120.89–$151.315
OH$116.191
OK$113.641
OR$126.75–$141.382
PA$116.82–$132.472
PR$128.661
RI$131.461
SC$117.591
SD$127.261
TN$115.681
TX$115.80–$134.648
UT$119.621
VA$125.09–$149.912
VI$128.661
VT$125.981
WA$134.00–$156.142
WI$121.911
WV$110.591
WY$127.261

Explore Q4101 on the national rate map →

Where does this rate apply?

Wyoming** is a Medicare payment area. Our Census mapping connects it to 205 cities and communities in Wyoming, including the examples shown here.

Some communities span more than one payment area. Follow a city link to compare all of its mapped areas, or check the service-location ZIP above for an address-level starting point.

Browse all communities in Wyoming →

Use this rate

What is a percentage of Medicare worth?

Turn a percentage into dollars for Q4101 in Wyoming**. This uses the base rate on this page, so the locality and release stay consistent.

Reference amount per service

$139.99

$127.26 × 110% = $139.99

A contract may specify another Medicare year or additional adjustments. This is percentage arithmetic on the displayed base rate, not a claim adjudication.

Working with a whole code list?

Compare an offer across your annual code mix, including an older Medicare schedule or flat per-code rates.

Compare your contract offer →

How this local rate is calculated

Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for Q4101 in Wyoming**.

PPRRVU2026_Oct_nonQPP.csv

18,201

Code
Q4101
Physician work
0.00
Practice expense
3.81
Malpractice
0.00

GPCI2026.csv

112

Locality
Wyoming**
Physician work
1.000
Practice expense
1.000
Malpractice
0.740
Office / nonfacility calculation for Q4101 in Wyoming**
ComponentRVULocality factorAdjusted
Physician work0.00× 1.0000.0000
Practice expense3.81× 1.0003.8100
Malpractice0.00× 0.7400.0000
Total RVUs3.8100
Conversion factor× 33.4009

Office / nonfacility rate, Wyoming**$127.26

Open Q4101 in the RVU calculator →

Explore RVUs, geographic factors and the full formula

Office / nonfacility

Office / nonfacility calculation inputs
ComponentRVULocal GPCI
Work01
Practice expense3.811
Malpractice00.74

(0 × 1 + 3.81 × 1 + 0 × 0.74) × $33.4009 = $127.26

The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.

How this rate has changed

Q4101 · Office / nonfacility

$127.26

Effective 2026-10-01

A rate is unavailable in one of these releases, so a change cannot be calculated.

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    No ratechanged to$127.26

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    Earliest loaded release: No rate

    Held through RVU25B, RVU25C, RVU25D.

Explore release dates and calculate this code in an earlier period →

Each row uses the accepted CMS release effective on that date and the same contractor and locality identifiers. Missing rates stay visible. Historical boundaries may differ; verify the service address for an older claim.

Inspect every release and its CMS source
Effective fromOffice / nonfacilityFacilityCMS release
2026-10-01$127.26Not available in this settingRVU26D
2026-07-01$127.26Not available in this settingRVU26C
2026-04-01$127.26Not available in this settingRVU26B
2026-01-01$127.26Not available in this settingRVU26A
2025-10-01Separate payment rules applySeparate payment rules applyRVU25D
2025-07-01Separate payment rules applySeparate payment rules applyRVU25C
2025-04-01Separate payment rules applySeparate payment rules applyRVU25B
2025-01-01Separate payment rules applySeparate payment rules applyRVU25A

Q4101 billing questions

Does Q4101 report the Apligraf application?

No. Q4101 reports the Apligraf product; report the applicable skin-substitute application procedure separately as the primary service.

What is the unit of service?

Q4101 is measured per square centimeter. Document the wound area treated and the amount of Apligraf used.

Can Q4101 be billed by itself?

No. It is an add-on code and must be reported with a primary procedure, such as the applicable skin-substitute application code.

How does the global-period rule affect payment?

Q4101 is paid within the primary procedure’s global period. Its payment is tied to that procedure rather than treated as a separate standalone service.

Does Q4101 include an interpretation?

No. CMS classifies Q4101 as technical-component-only, and a separate code covers interpretation.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.

Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.

RVUs for Q4101PPRRVU2026_Oct_nonQPP.csv, line 18,201 (RVU26D)
Geographic factors for Wyoming**GPCI2026.csv, line 112 (RVU26D)
Open CMS sourceHow this rate is calculatedBuild a fee sheet