$58.54
88373 represents manual ISH morphometric analysis. This code is for the computer-assisted method.
On this page
CMS RVU26D · Effective 2026-10-01
88374 ISH analysis Medicare reimbursement rates in Kentucky
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization findings in a tissue specimen. Compare 88374 office and facility rates across CMS payment localities in Kentucky.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88374 in Kentucky?
Kentucky has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$240.05
1 of 1 localities have a supported rate.
Payment area: Kentucky
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88374: Computer-assisted ISH morphometric analysis
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization findings in a tissue specimen.
A pathology laboratory uses image-analysis technology to quantify or semiquantify in situ hybridization signals in a tissue specimen. The analysis supports interpretation of molecular markers visible in cells or tissue, such as gene-copy patterns assessed in a tumor biopsy. A pathologist reviews the findings and incorporates them into the diagnostic workup; the technical work is generally performed by laboratory staff using specialized imaging equipment.
Select this service when the requested work is morphometric analysis of an in situ hybridization assay using computer-assisted technology, rather than manual measurement or tumor immunohistochemistry analysis. The record should identify the specimen, the assay and target, the quantitative or semiquantitative analysis performed, and the resulting interpretation. CMS recognizes separately priced professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the equipment-and-staff portion, and reporting without either modifier represents the global service.
CMS billing rules for 88374
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.91 · 11%
- Practice expense (office) RVU7.04 · 88%
- Malpractice RVU0.02 · 0%
181K
Medicare services in 2024 · #403 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88374 compared with similar codes
Office rates for Kentucky, from the same CMS release.
$109.99
88360 concerns morphometric analysis of tumor immunohistochemistry using a manual method. This code concerns ISH findings analyzed with computer assistance.
$105.31
88361 is computer-assisted morphometric analysis of tumor immunohistochemistry; this code is for computer-assisted morphometric analysis of ISH.
Compare 88374 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Kentucky →
Office / nonfacility
$240.05
Facility
Unavailable
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How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88374 in Kentucky.
PPRRVU2026_Oct_nonQPP.csv
11,310
- Code
- 88374
- Physician work
- 0.91
- Practice expense
- 7.04
- Malpractice
- 0.02
GPCI2026.csv
55
- Locality
- Kentucky
- Physician work
- 1.000
- Practice expense
- 0.889
- Malpractice
- 0.915
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.91 | × 1.000 | 0.9100 |
| Practice expense | 7.04 | × 0.889 | 6.2586 |
| Malpractice | 0.02 | × 0.915 | 0.0183 |
| Total RVUs | 7.1869 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Kentucky$240.05
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0.91 | 1 |
| Practice expense | 7.04 | 0.889 |
| Malpractice | 0.02 | 0.915 |
(0.91 × 1 + 7.04 × 0.889 + 0.02 × 0.915) × $33.4009 = $240.05
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88374 billing questions
How does this differ from manual ISH morphometric analysis?
This code is for quantitative or semiquantitative ISH morphometric analysis performed with computer-assisted technology. Use the manual counterpart when the morphometric analysis is performed manually.
Is this the same as tumor immunohistochemistry analysis?
No. This service analyzes in situ hybridization findings; tumor immunohistochemistry analysis evaluates immunostaining and is reported with the applicable IHC morphometric-analysis code.
Which modifiers identify the components?
Modifier 26 reports the professional interpretation, and modifier TC reports the technical service, including equipment and staff. Without either modifier, the claim represents the global service.
What documentation supports reporting this service?
Document the specimen and ISH assay, the use of computer-assisted quantitative or semiquantitative morphometric analysis, and the pathologist's interpretation of the findings.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,30788373,,M/phmtrc alys ishquant/semiq,A,,0.57,1.32,,1.32,NA,0.01,1.90,1.90,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30888373,26,M/phmtrc alys ishquant/semiq,A,,0.57,0.14,,0.14,,0.00,0.71,0.71,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30988373,TC,M/phmtrc alys ishquant/semiq,A,,0.00,1.18,,1.18,NA,0.01,1.19,1.19,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31088374,,M/phmtrc alys ishquant/semiq,A,,0.91,7.04,,7.04,NA,0.02,7.97,7.97,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31188374,26,M/phmtrc alys ishquant/semiq,A,,0.91,0.26,,0.26,,0.01,1.18,1.18,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31288374,TC,M/phmtrc alys ishquant/semiq,A,,0.00,6.78,,6.78,NA,0.01,6.79,6.79,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31388375,,Optical endomicroscpy interp,A,,0.89,0.41,,0.41,,0.05,1.35,1.35,2,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
5208102,IN,00,INDIANA,1.000,0.927,0.486
5305102,IA,00,IOWA,1.000,0.915,0.397
5405202,KS,00,KANSAS,1.000,0.904,0.504
5515102,KY,00,KENTUCKY,1.000,0.889,0.915
5607202,LA,01,NEW ORLEANS,1.000,0.941,1.136
5707202,LA,99,REST OF LOUISIANA,1.000,0.885,0.958
5814112,ME,03,SOUTHERN MAINE,1.000,0.991,0.631