$57.08–$84.89
88373 represents manual ISH morphometric analysis. This code is for the computer-assisted method.
On this page
CMS RVU26D · Effective 2026-10-01
88374 ISH analysis Medicare reimbursement rates
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization findings in a tissue specimen. Compare 88374 office and facility rates across CMS payment localities.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88374?
The service location and office or facility setting determine which base rate applies. These are the supported base rates for the 109 payment areas shown below, using the same CMS release.
Office / nonfacility
$232.73–$373.17
109 of 109 localities have a supported rate.
Lowest: Arkansas
Highest: San Jose-Sunnyvale-Santa Clara (San Benito Cnty)
A spread of $140.44 per service.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Where 88374 pays more and less
109 payment localities
$232.73 to $373.17
Surgical pathology
About 88374: Computer-assisted ISH morphometric analysis
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization findings in a tissue specimen.
A pathology laboratory uses image-analysis technology to quantify or semiquantify in situ hybridization signals in a tissue specimen. The analysis supports interpretation of molecular markers visible in cells or tissue, such as gene-copy patterns assessed in a tumor biopsy. A pathologist reviews the findings and incorporates them into the diagnostic workup; the technical work is generally performed by laboratory staff using specialized imaging equipment.
Select this service when the requested work is morphometric analysis of an in situ hybridization assay using computer-assisted technology, rather than manual measurement or tumor immunohistochemistry analysis. The record should identify the specimen, the assay and target, the quantitative or semiquantitative analysis performed, and the resulting interpretation. CMS recognizes separately priced professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the equipment-and-staff portion, and reporting without either modifier represents the global service.
CMS billing rules for 88374
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.91 · 11%
- Practice expense (office) RVU7.04 · 88%
- Malpractice RVU0.02 · 0%
181K
Medicare services in 2024 · #403 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88374 compared with similar codes
Office rate ranges across all CMS payment localities, from the same CMS release.
$106.97–$163.58
88360 concerns morphometric analysis of tumor immunohistochemistry using a manual method. This code concerns ISH findings analyzed with computer assistance.
$102.56–$154.28
88361 is computer-assisted morphometric analysis of tumor immunohistochemistry; this code is for computer-assisted morphometric analysis of ISH.
See how rates vary across the country
88374 · Office / nonfacility · Non-QP. Choose a state to explore its payment localities. A range means the amount varies within that state.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$232.73
$331.08
Color shows the midpoint of each state’s locality range.
View all state and territory rates as a table
| State / territory | Rate range | Localities |
|---|---|---|
| AK | $296.39 | 1 |
| AL | $236.52 | 1 |
| AR | $232.73 | 1 |
| AZ | $258.82 | 1 |
| CA | $288.99–$373.17 | 29 |
| CO | $281.47 | 1 |
| CT | $285.06 | 1 |
| DC | $309.78 | 1 |
| DE | $263.47 | 1 |
| FL | $256.19–$276.87 | 3 |
| GA | $240.94–$270.19 | 2 |
| GU | $298.14 | 1 |
| HI | $298.14 | 1 |
| IA | $245.82 | 1 |
| ID | $247.04 | 1 |
| IL | $246.12–$273.28 | 4 |
| IN | $248.70 | 1 |
| KS | $243.30 | 1 |
| KY | $240.05 | 1 |
| LA | $239.14–$252.42 | 2 |
| MA | $279.02–$313.00 | 2 |
| MD | $269.28–$309.78 | 3 |
| ME | $247.14–$263.84 | 2 |
| MI | $245.83–$258.43 | 2 |
| MN | $272.55 | 1 |
| MO | $233.74–$254.92 | 3 |
| MS | $233.35 | 1 |
| MT | $266.20 | 1 |
| NC | $250.21 | 1 |
| ND | $265.81 | 1 |
| NE | $247.68 | 1 |
| NH | $275.76 | 1 |
| NJ | $289.12–$305.79 | 2 |
| NM | $246.82 | 1 |
| NV | $266.33 | 1 |
| NY | $254.25–$313.16 | 5 |
| OH | $245.75 | 1 |
| OK | $240.90 | 1 |
| OR | $265.07–$292.62 | 2 |
| PA | $246.89–$276.52 | 2 |
| PR | $268.78 | 1 |
| RI | $274.47 | 1 |
| SC | $248.23 | 1 |
| SD | $265.76 | 1 |
| TN | $244.50 | 1 |
| TX | $244.99–$279.83 | 8 |
| UT | $252.03 | 1 |
| VA | $262.01–$309.78 | 2 |
| VI | $268.78 | 1 |
| VT | $263.52 | 1 |
| WA | $278.90–$320.98 | 2 |
| WI | $255.87 | 1 |
| WV | $235.69 | 1 |
| WY | $266.03 | 1 |
Compare 88374 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
109 of 109 payment localities
| Payment locality | Office | Facility |
|---|---|---|
| Alabama | Office $236.52 | Facility Unavailable |
| Alaska* | Office $296.39 | Facility Unavailable |
| Arizona | Office $258.82 | Facility Unavailable |
| Arkansas | Office $232.73 | Facility Unavailable |
| Atlanta | Office $270.19 | Facility Unavailable |
| Austin | Office $279.83 | Facility Unavailable |
| Bakersfield | Office $289.10 | Facility Unavailable |
| Baltimore/Surr. Cntys | Office $284.02 | Facility Unavailable |
| Beaumont | Office $244.99 | Facility Unavailable |
| Brazoria | Office $264.19 | Facility Unavailable |
| Chicago | Office $268.46 | Facility Unavailable |
| Chico | Office $288.99 | Facility Unavailable |
| Colorado | Office $281.47 | Facility Unavailable |
| Connecticut | Office $285.06 | Facility Unavailable |
| Dallas | Office $265.44 | Facility Unavailable |
| Dc + Md/Va Suburbs | Office $309.78 | Facility Unavailable |
| Delaware | Office $263.47 | Facility Unavailable |
| Detroit | Office $258.43 | Facility Unavailable |
| East St. Louis | Office $248.07 | Facility Unavailable |
| El Centro | Office $288.99 | Facility Unavailable |
| Fort Lauderdale | Office $269.80 | Facility Unavailable |
| Fort Worth | Office $263.10 | Facility Unavailable |
| Fresno | Office $288.99 | Facility Unavailable |
| Galveston | Office $264.69 | Facility Unavailable |
| Hanford-Corcoran | Office $288.99 | Facility Unavailable |
| Hawaii, Guam | Office $298.14 | Facility Unavailable |
| Houston | Office $265.05 | Facility Unavailable |
| Idaho | Office $247.04 | Facility Unavailable |
| Indiana | Office $248.70 | Facility Unavailable |
| Iowa | Office $245.82 | Facility Unavailable |
| Kansas | Office $243.30 | Facility Unavailable |
| Kentucky | Office $240.05 | Facility Unavailable |
| Los Angeles-Long Beach-Anaheim (Los Angeles/Orange Cnty) | Office $310.26 | Facility Unavailable |
| Madera | Office $288.99 | Facility Unavailable |
| Manhattan | Office $306.63 | Facility Unavailable |
| Merced | Office $288.99 | Facility Unavailable |
| Metropolitan Boston | Office $313.00 | Facility Unavailable |
| Metropolitan Kansas City | Office $251.85 | Facility Unavailable |
| Metropolitan Philadelphia | Office $276.52 | Facility Unavailable |
| Metropolitan St. Louis | Office $254.92 | Facility Unavailable |
| Miami | Office $276.87 | Facility Unavailable |
| Minnesota | Office $272.55 | Facility Unavailable |
| Mississippi | Office $233.35 | Facility Unavailable |
| Modesto | Office $288.99 | Facility Unavailable |
| Montana** | Office $266.20 | Facility Unavailable |
| Napa | Office $342.57 | Facility Unavailable |
| Nebraska | Office $247.68 | Facility Unavailable |
| Nevada** | Office $266.33 | Facility Unavailable |
| New Hampshire | Office $275.76 | Facility Unavailable |
| New Mexico | Office $246.82 | Facility Unavailable |
| New Orleans | Office $252.42 | Facility Unavailable |
| North Carolina | Office $250.21 | Facility Unavailable |
| North Dakota** | Office $265.81 | Facility Unavailable |
| Northern Nj | Office $305.79 | Facility Unavailable |
| Nyc Suburbs/Long Island | Office $313.16 | Facility Unavailable |
| Ohio | Office $245.75 | Facility Unavailable |
| Oklahoma | Office $240.90 | Facility Unavailable |
| Oxnard-Thousand Oaks-Ventura | Office $309.60 | Facility Unavailable |
| Portland | Office $292.62 | Facility Unavailable |
| Poughkpsie/N Nyc Suburbs | Office $290.05 | Facility Unavailable |
| Puerto Rico | Office $268.78 | Facility Unavailable |
| Queens | Office $311.24 | Facility Unavailable |
| Redding | Office $288.99 | Facility Unavailable |
| Rest Of California | Office $288.99 | Facility Unavailable |
| Rest Of Florida | Office $256.19 | Facility Unavailable |
| Rest Of Georgia | Office $240.94 | Facility Unavailable |
| Rest Of Illinois | Office $246.12 | Facility Unavailable |
| Rest Of Louisiana | Office $239.14 | Facility Unavailable |
| Rest Of Maine | Office $247.14 | Facility Unavailable |
| Rest Of Maryland | Office $269.28 | Facility Unavailable |
| Rest Of Massachusetts | Office $279.02 | Facility Unavailable |
| Rest Of Michigan | Office $245.83 | Facility Unavailable |
| Rest Of Missouri | Office $233.74 | Facility Unavailable |
| Rest Of New Jersey | Office $289.12 | Facility Unavailable |
| Rest Of New York | Office $254.25 | Facility Unavailable |
| Rest Of Oregon | Office $265.07 | Facility Unavailable |
| Rest Of Pennsylvania | Office $246.89 | Facility Unavailable |
| Rest Of Texas | Office $254.15 | Facility Unavailable |
| Rest Of Washington | Office $278.90 | Facility Unavailable |
| Rhode Island | Office $274.47 | Facility Unavailable |
| Riverside-San Bernardino-Ontario | Office $289.23 | Facility Unavailable |
| Sacramento-Roseville-Folsom | Office $305.32 | Facility Unavailable |
| Salinas | Office $304.23 | Facility Unavailable |
| San Diego-Chula Vista-Carlsbad | Office $312.90 | Facility Unavailable |
| San Francisco-Oakland-Berkeley (Marin Cnty) | Office $365.14 | Facility Unavailable |
| San Francisco-Oakland-Berkeley (San Francisco/San Mateo/Alameda/Contra Costa Cnty) | Office $365.12 | Facility Unavailable |
| San Jose-Sunnyvale-Santa Clara (San Benito Cnty) | Office $373.17 | Facility Unavailable |
| San Jose-Sunnyvale-Santa Clara (Santa Clara Cnty) | Office $373.08 | Facility Unavailable |
| San Luis Obispo-Paso Robles | Office $299.10 | Facility Unavailable |
| Santa Cruz-Watsonville | Office $317.09 | Facility Unavailable |
| Santa Maria-Santa Barbara | Office $305.78 | Facility Unavailable |
| Santa Rosa-Petaluma | Office $320.42 | Facility Unavailable |
| Seattle (King Cnty) | Office $320.98 | Facility Unavailable |
| South Carolina | Office $248.23 | Facility Unavailable |
| South Dakota** | Office $265.76 | Facility Unavailable |
| Southern Maine | Office $263.84 | Facility Unavailable |
| Stockton | Office $288.99 | Facility Unavailable |
| Suburban Chicago | Office $273.28 | Facility Unavailable |
| Tennessee | Office $244.50 | Facility Unavailable |
| Utah | Office $252.03 | Facility Unavailable |
| Vallejo | Office $342.53 | Facility Unavailable |
| Vermont | Office $263.52 | Facility Unavailable |
| Virgin Islands | Office $268.78 | Facility Unavailable |
| Virginia | Office $262.01 | Facility Unavailable |
| Visalia | Office $288.99 | Facility Unavailable |
| West Virginia | Office $235.69 | Facility Unavailable |
| Wisconsin | Office $255.87 | Facility Unavailable |
| Wyoming** | Office $266.03 | Facility Unavailable |
| Yuba City | Office $288.99 | Facility Unavailable |
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88374 billing questions
How does this differ from manual ISH morphometric analysis?
This code is for quantitative or semiquantitative ISH morphometric analysis performed with computer-assisted technology. Use the manual counterpart when the morphometric analysis is performed manually.
Is this the same as tumor immunohistochemistry analysis?
No. This service analyzes in situ hybridization findings; tumor immunohistochemistry analysis evaluates immunostaining and is reported with the applicable IHC morphometric-analysis code.
Which modifiers identify the components?
Modifier 26 reports the professional interpretation, and modifier TC reports the technical service, including equipment and staff. Without either modifier, the claim represents the global service.
What documentation supports reporting this service?
Document the specimen and ISH assay, the use of computer-assisted quantitative or semiquantitative morphometric analysis, and the pathologist's interpretation of the findings.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,30788373,,M/phmtrc alys ishquant/semiq,A,,0.57,1.32,,1.32,NA,0.01,1.90,1.90,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30888373,26,M/phmtrc alys ishquant/semiq,A,,0.57,0.14,,0.14,,0.00,0.71,0.71,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30988373,TC,M/phmtrc alys ishquant/semiq,A,,0.00,1.18,,1.18,NA,0.01,1.19,1.19,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31088374,,M/phmtrc alys ishquant/semiq,A,,0.91,7.04,,7.04,NA,0.02,7.97,7.97,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31188374,26,M/phmtrc alys ishquant/semiq,A,,0.91,0.26,,0.26,,0.01,1.18,1.18,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31288374,TC,M/phmtrc alys ishquant/semiq,A,,0.00,6.78,,6.78,NA,0.01,6.79,6.79,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,31388375,,Optical endomicroscpy interp,A,,0.89,0.41,,0.41,,0.05,1.35,1.35,2,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00