$162.76–$179.04
15271 describes applying a skin substitute to an eligible leg wound. Q4278 identifies the EpiEffect material used during that procedure.
On this page
CMS RVU26D · Effective 2026-10-01
Q4278 EpiEffect Medicare reimbursement rates in Massachusetts
Report EpiEffect by square centimeter when the product is applied to a wound alongside the appropriate skin substitute application procedure. Compare Q4278 office and facility rates across CMS payment localities in Massachusetts.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for Q4278 in Massachusetts?
Massachusetts has 2 payment localities in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the 2 payment areas shown below, using the same CMS release.
Office / nonfacility
$134.00–$151.95
2 of 2 localities have a supported rate.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Skin substitutes
About Q4278: EpiEffect skin substitute, per square centimeter
Report EpiEffect by square centimeter when the product is applied to a wound alongside the appropriate skin substitute application procedure.
Q4278 identifies the EpiEffect product used during a skin substitute application. A physician or podiatrist may apply it to a wound, such as a diabetic foot ulcer or venous leg ulcer, in an office or outpatient wound clinic. The product code identifies the material; the application procedure describes the clinician’s work preparing and covering the wound.
Report Q4278 in square centimeters of EpiEffect used, supported by the product name, wound location, and amount applied in the treatment record. Choose the primary application procedure according to the wound site and treated area; for example, a leg wound and a foot wound fall under different application codes. CMS treats Q4278 as an add-on billed only with a primary procedure, with payment within that procedure’s global period. CMS also classifies Q4278 as technical-component-only: any interpretation is covered by a separate code, not by Q4278.
CMS billing rules for Q4278
- Global period
- Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
- Professional and technical components
- Technical-component-only code: a separate code covers interpretation.
Where the value comes from
- Work RVU0.00 · 0%
- Practice expense (office) RVU3.81 · 100%
- Malpractice RVU0.00 · 0%
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Q4278 compared with similar codes
Office rates for Massachusetts, from the same CMS release.
$164.91–$180.30
15275 describes applying a skin substitute to an eligible foot wound. Q4278 identifies the EpiEffect product, not the application work.
$134.00–$151.95
Both are product codes measured per square centimeter. Use Q4278 for EpiEffect and Q4279 for Vendaje AC.
$134.00–$151.95
Q4280 identifies Xcell Amnio Matrix per square centimeter; Q4278 identifies EpiEffect. Select the code for the product documented as used.
Compare Q4278 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
2 of 2 payment localities
Metropolitan Boston →
Office / nonfacility
$151.95
Facility
Unavailable
Rest Of Massachusetts →
Office / nonfacility
$134.00
Facility
Unavailable
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Q4278 billing questions
Does Q4278 replace the skin substitute application code?
No. Q4278 identifies the EpiEffect product and is billed with the primary procedure describing its application.
How are Q4278 units determined?
Each unit represents one square centimeter of EpiEffect. Support the units with documentation of the product and amount used, rather than assuming the product quantity equals the wound measurement.
Which application code pairs with Q4278 for a leg or foot wound?
For an eligible leg wound, 15271 describes the initial application area; for an eligible foot wound, 15275 serves that role. Select the procedure from the documented site and treated area.
Can Q4278 be used when a different skin substitute was applied?
No. Use the product code for the material actually documented as applied; Q4278 identifies EpiEffect specifically.
Does Q4278 include interpretation or have its own global period?
CMS classifies Q4278 as technical-component-only and assigns interpretation to a separate code. As an add-on, it is paid within the primary procedure’s global period.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
18,362Q4274,,"Esano ac, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,363Q4275,,"Esano aca, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,364Q4276,,"Orion, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,365Q4278,,"Epieffect, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,366Q4279,,"Vendaje ac, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,367Q4280,,Xcell amnio matrix per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,368Q4281,,Barrera slor dl per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00