$116.19–$122.80
Q4279 identifies Vendaje AC rather than Xcell amniotic matrix. Report the code for the product actually used.
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CMS RVU26D · Effective 2026-10-01
Q4280 Amniotic matrix Medicare reimbursement rates in Michigan
Report Q4280 for each square centimeter of Xcell amniotic matrix supplied for wound treatment alongside the related primary procedure. Compare Q4280 office and facility rates across CMS payment localities in Michigan.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for Q4280 in Michigan?
Michigan has 2 payment localities in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the 2 payment areas shown below, using the same CMS release.
Office / nonfacility
$116.19–$122.80
2 of 2 localities have a supported rate.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Wound care supply
About Q4280: Xcell amniotic matrix product
Report Q4280 for each square centimeter of Xcell amniotic matrix supplied for wound treatment alongside the related primary procedure.
Q4280 identifies Xcell amniotic matrix used as a wound-covering product. A physician or other qualified practitioner may apply it to a prepared wound in an outpatient wound clinic, office, or hospital outpatient setting. The HCPCS line represents the product, not the clinical work of preparing the wound or applying the matrix; those services are reported separately when supported by the encounter.
Report the quantity in square centimeters and document the product used and the amount applied. Q4280 is an add-on code and must be billed with a primary procedure; Medicare payment for it falls within that procedure’s global period. CMS classifies Q4280 as technical-component-only, with a separate code covering interpretation. Application CPT selection depends on the wound site and treated area, not on the product code.
CMS billing rules for Q4280
- Global period
- Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
- Professional and technical components
- Technical-component-only code: a separate code covers interpretation.
Where the value comes from
- Work RVU0.00 · 0%
- Practice expense (office) RVU3.81 · 100%
- Malpractice RVU0.00 · 0%
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Q4280 compared with similar codes
Office rates for Michigan, from the same CMS release.
$116.19–$122.80
Q4281 identifies Barrera SLOR DL, a different product. Q4280 is specific to Xcell amniotic matrix.
$150.00–$159.22
15271 reports application work for eligible trunk, arm, or leg wounds; Q4280 reports the Xcell matrix product in square centimeters.
$152.99–$161.61
15275 reports application work for eligible head, neck, hand, foot, or genital wounds; it does not identify the matrix product.
Compare Q4280 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
2 of 2 payment localities
Detroit →
Office / nonfacility
$122.80
Facility
Unavailable
Rest Of Michigan →
Office / nonfacility
$116.19
Facility
Unavailable
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Q4280 billing questions
Does Q4280 report the matrix or its application?
It reports the Xcell amniotic matrix product. Report the wound application service separately when supported, using the CPT code that matches the site and treated area.
How should units be reported?
The descriptor is per square centimeter. Document the amount of Xcell matrix used and report the corresponding square-centimeter quantity.
Can Q4280 be billed by itself?
No. CMS identifies it as an add-on code that must be billed with a primary procedure.
Which application code is commonly reported with Q4280?
A skin-substitute application code may accompany it, such as 15271 for an eligible trunk, arm, or leg site or 15275 for an eligible head, neck, hand, foot, or genital site. Select the application code based on the actual wound site and area.
Does Q4280 include interpretation?
No. CMS classifies Q4280 as technical-component-only and indicates that a separate code covers interpretation.
What documentation supports Q4280?
Record the Xcell product, wound site, square-centimeter quantity used, and the related primary procedure. The record should also support the separately reported application service.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
18,364Q4276,,"Orion, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,365Q4278,,"Epieffect, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,366Q4279,,"Vendaje ac, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,367Q4280,,Xcell amnio matrix per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,368Q4281,,Barrera slor dl per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,369Q4282,,Cygnus dual per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,370Q4283,,"Biovance tri or 3l, sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00