HCPCS Q4280: Amniotic matrixMedicare rate & RVUs

Medicare pays $127.26 for Q4280 nationally in the office. Local office rates run $109.31–$183.51.

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What Q4280 covers

Q4280 identifies Xcell amniotic matrix used as a wound-covering product. A physician or other qualified practitioner may apply it to a prepared wound in an outpatient wound clinic, office, or hospital outpatient setting. The HCPCS line represents the product, not the clinical work of preparing the wound or applying the matrix; those services are reported separately when supported by the encounter.

Report the quantity in square centimeters and document the product used and the amount applied. Q4280 is an add-on code and must be billed with a primary procedure; Medicare payment for it falls within that procedure’s global period. CMS classifies Q4280 as technical-component-only, with a separate code covering interpretation. Application billing code selection depends on the wound site and treated area, not on the product code.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4280 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

Q4280 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the Q4280 rate is calculated

Each of Q4280’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for Q4280

The CMS indicators that decide how Q4280 is paid alongside other services.

Q4280 compared with similar codes

How to choose

Q4279Wound product

Q4279 identifies Vendaje AC rather than Xcell amniotic matrix. Report the code for the product actually used.

Q4281Wound product

Q4281 identifies Barrera SLOR DL, a different product. Q4280 is specific to Xcell amniotic matrix.

15271Skin substitute graft

15271 reports application work for eligible trunk, arm, or leg wounds; Q4280 reports the Xcell matrix product in square centimeters.

15275Skin substitute

15275 reports application work for eligible head, neck, hand, foot, or genital wounds; it does not identify the matrix product.

Codes related to Q4280

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates