Billing code 40808: Mouth biopsyMedicare rate & RVUs in Minnesota

Reports tissue sampling of a lesion in the oral vestibule, the space between the lips or cheeks and the teeth and gums, for diagnosis.

CMS RVU26DEffective Oct 1, 20261 payment locality8.5K Medicare services in 2024

Medicare pays $168.46 for 40808 in the office in Minnesota (Minnesota). Which amount applies depends on the service address.

$168.46Office (non-facility)
$80.48Hospital or facility

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 40808 for the payment locality that covers the ZIP.

On this page 9 sections
  1. Rate in Minnesota
  2. What 40808 covers
  3. By payment locality
  4. How it’s calculated
  5. Payment rules
  6. Similar codes
  7. Related codes
  8. Billing questions
  9. Sources

What 40808 covers

This service samples a lesion in the oral vestibule—the lining inside the lips or cheeks, between them and the teeth and gums. A dentist, oral surgeon, or otolaryngologist may perform it in an office or outpatient setting when a persistent ulcer, abnormal patch, or other lesion needs tissue diagnosis. The specimen is sent for pathologic examination; the code represents the biopsy procedure, not the laboratory’s tissue analysis.

Report 40808 when tissue is sampled from the vestibule rather than when the lesion is removed by excision or lies at a different oral site. Document the lesion’s location and appearance, the tissue obtained, and the procedure performed. CMS assigns a 10-day global period, so related postoperative visits during that period are included. When multiple procedures are performed in the same session, the highest-valued procedure is paid in full and the others are subject to the standard 50% reduction. Modifier 50 is inappropriate for this code. Medicare does not pay an assistant at surgery for it, and co-surgeons and team surgery are not permitted.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

40808 in Minnesota

40808 office and facility rates by payment locality
Payment localityOfficeFacility
Minnesota$168.46$80.48

How the 40808 rate is calculated

Each of 40808’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 40808

RVUs × geographic indexes × conversion factor

Work1.02

1.02 RVUs× 1.000 GPCI

Practice expense3.87

3.87 RVUs× 1.000 GPCI

Malpractice0.14

0.14 RVUs× 1.000 GPCI

Adjusted RVUs

5.0300

Conversion factor

$33.4009

Medicare rate

$168.01

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for 40808

40808 has a 10-day global period: related visits in that window are included in the surgery payment.

CMS payment indicators · 40808

Mouth biopsy

RuleCMS valueWhat it means
Global period010Minor procedure: the day of the procedure plus 10 days after are included.
Multiple procedures2Standard reduction: highest-valued procedure at 100%, others at 50%.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)1Not paid (statutory restriction).
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.
Split (54/55/56)0.10/0.80/0.10Share of the payment for pre-op, the procedure itself, and post-op care.

Global surgery period · 40808

Mouth biopsy

10-day global period ends

Oct 11, 2026

Covers Oct 1, 2026 through Oct 11, 2026 (11 days).

Visit on Oct 31, 2026

After the global period ends: visits and procedures are billed normally.

SurgeryVisit
Sep 28, 2026Oct 14, 2026

What modifiers do to the payment

Modifier 51 · payment effect

With and without the modifier

40808 without 51 · national office

$168.01

Mouth biopsy

40808-51 · Second procedure: 50%

$84.01

When this isn’t the highest-valued procedure in the session, Medicare pays 50% of its fee schedule amount (the highest is paid at 100%).

When to use modifier 51

40808 compared with similar codes

Compare codes · National

4 codes, side by side

  • 40808

    Mouth biopsy1.02 wRVU

    $168.01

  • 40810

    Mouth lesion excision1.33 wRVU

    $216.10+$48.09

  • 40490

    Lip biopsy1.19 wRVU

    $120.24−$47.77

  • 41100

    Tongue biopsy1.38 wRVU

    $188.05+$20.04

How to choose

40810Mouth lesion excision
Use 40808 when tissue is sampled from a vestibular lesion. Use 40810 when the clinician excises the lesion rather than taking a biopsy.
40490Lip biopsy
Both describe oral-site biopsies, but 40490 is for a lesion of the lip; 40808 is for the oral vestibule.
41100Tongue biopsy
41100 is for a tongue biopsy. Choose 40808 when the sampled lesion is in the vestibule between the lips or cheeks and the teeth and gums.

40808 billing questions

How is 40808 different from 40810?

40808 is for tissue sampling of a vestibular lesion. Choose an excision code such as 40810 when the service removes the lesion rather than taking a biopsy sample.

Can the pathology examination be billed separately?

The biopsy code represents the clinician’s tissue-sampling procedure. The laboratory or pathologist may separately report the appropriate examination of the submitted specimen.

Should modifier 50 be appended for lesions on both sides?

No. CMS identifies bilateral adjustment as inappropriate for 40808; modifier 50 should not be used for this service.

Are related follow-up visits included?

Yes. The code has a 10-day global period, which includes related postoperative visits during that period.

Can an assistant surgeon or co-surgeon be reported?

Medicare does not pay an assistant at surgery for 40808. Co-surgeons and team surgery are not permitted for this code.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 40808PPRRVU2026_Oct_nonQPP.csv, line 4,862 (RVU26D)
Geographic factors for MinnesotaGPCI2026.csv, line 66 (RVU26D)

Open CMS sourceHow we calculate rates

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