$172.34
88365 covers the in situ hybridization stain procedure; 88368 covers manual morphometric analysis of the signals. They may both be reported when both services are performed.
On this page
CMS RVU26D · Effective 2026-10-01
88368 ISH analysis Medicare reimbursement rates in Minnesota
Reports manual morphometric measurement of in situ hybridization signals in a specimen, such as manual signal counting for tumor biomarker assessment. Compare 88368 office and facility rates across CMS payment localities in Minnesota.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 88368 in Minnesota?
Minnesota has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$148.63
1 of 1 localities have a supported rate.
Payment area: Minnesota
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Surgical pathology
About 88368: Manual ISH morphometric analysis
Reports manual morphometric measurement of in situ hybridization signals in a specimen, such as manual signal counting for tumor biomarker assessment.
This service involves manually measuring or counting signals on an in situ hybridization preparation under a microscope. A pathologist or laboratory professional may perform the analysis as part of evaluating a tissue specimen; a familiar example is counting HER2 signals in tumor cells during assessment of amplification. The analysis focuses on the hybridization results, rather than simply preparing and staining the specimen.
Select this code for manual morphometric analysis of the initial single-probe stain procedure for a specimen. Documentation should identify the specimen and probe, support that the analysis was performed manually, and record the findings and interpretation. CMS recognizes separate professional and technical components: modifier 26 identifies the interpretation, modifier TC identifies the equipment and staff service, and an unmodified claim represents the global service.
CMS billing rules for 88368
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.86 · 20%
- Practice expense (office) RVU3.48 · 80%
- Malpractice RVU0.03 · 1%
17.9K
Medicare services in 2024 · #1191 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
88368 compared with similar codes
Office rates for Minnesota, from the same CMS release.
$106.74
Both codes cover morphometric analysis of an initial single-probe procedure. Choose 88368 for manual analysis and 88367 for automated analysis.
$131.52
88368 is for the initial single-probe manual analysis for a specimen. 88369 represents manual morphometric analysis for each additional single-probe stain procedure.
Compare 88368 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Minnesota →
Office / nonfacility
$148.63
Facility
Unavailable
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How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88368 in Minnesota.
PPRRVU2026_Oct_nonQPP.csv
11,297
- Code
- 88368
- Physician work
- 0.86
- Practice expense
- 3.48
- Malpractice
- 0.03
GPCI2026.csv
66
- Locality
- Minnesota
- Physician work
- 1.000
- Practice expense
- 1.029
- Malpractice
- 0.296
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.86 | × 1.000 | 0.8600 |
| Practice expense | 3.48 | × 1.029 | 3.5809 |
| Malpractice | 0.03 | × 0.296 | 0.0089 |
| Total RVUs | 4.4498 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Minnesota$148.63
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0.86 | 1 |
| Practice expense | 3.48 | 1.029 |
| Malpractice | 0.03 | 0.296 |
(0.86 × 1 + 3.48 × 1.029 + 0.03 × 0.296) × $33.4009 = $148.63
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
88368 billing questions
How is this different from 88365?
88365 reports the in situ hybridization stain procedure. 88368 reports manual morphometric measurement of the resulting signals; report both when both distinct services are performed and documented.
When is 88368 selected instead of 88367?
Use 88368 when the morphometric analysis is performed manually. Code 88367 is the automated counterpart for the initial single-probe procedure.
What does the unit represent?
The initial manual morphometric analysis is reported per specimen for a single probe stain procedure. The manual additional-probe analysis is represented by 88369.
How should the professional and technical work be billed?
Use modifier 26 for the interpretation and modifier TC for the equipment and staff service. Without either modifier, the code represents the global service.
What documentation supports manual analysis?
Document the specimen, probe, manual signal measurement or counting performed, and the resulting findings and interpretation. The record should distinguish this analysis from the stain preparation itself.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
11,29488367,,Insitu hybridization auto,A,,0.71,2.41,,2.41,NA,0.02,3.14,3.14,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29588367,26,Insitu hybridization auto,A,,0.71,0.21,,0.21,,0.01,0.93,0.93,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29688367,TC,Insitu hybridization auto,A,,0.00,2.20,,2.20,NA,0.01,2.21,2.21,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29788368,,Insitu hybridization manual,A,,0.86,3.48,,3.48,NA,0.03,4.37,4.37,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29888368,26,Insitu hybridization manual,A,,0.86,0.33,,0.33,,0.01,1.20,1.20,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,29988368,TC,Insitu hybridization manual,A,,0.00,3.15,,3.15,NA,0.02,3.17,3.17,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
11,30088369,,M/phmtrc alysishquant/semiq,A,,0.68,3.16,,3.16,NA,0.02,3.86,3.86,1,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
6314212,MA,99,REST OF MASSACHUSETTS,1.016,1.053,0.797
6408202,MI,01,DETROIT,1.000,0.965,1.686
6508202,MI,99,REST OF MICHIGAN,1.000,0.913,1.129
6606202,MN,00,MINNESOTA,1.000,1.029,0.296
6707302,MS,00,MISSISSIPPI,1.000,0.861,0.739
6805302,MO,02,METROPOLITAN KANSAS CITY,1.000,0.939,0.977
6905302,MO,01,METROPOLITAN ST. LOUIS,1.000,0.952,1.002